Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Recent
years
have
witnessed
the
emergence
of
direct
intermolecular
C(sp
Язык: Английский
Visible-light-driven asymmetric aldol reaction of ketones and glycinates via synergistic Lewis acid/photoredox catalysis
Chemical Science,
Год журнала:
2024,
Номер
15(39), С. 16050 - 16058
Опубликована: Янв. 1, 2024
We
have
synthesized
β-diaryl-β-hydroxyl-α-amino
acid
derivatives
through
radical
addition-type
aldol
reaction,
which
was
confirmed
by
spectroscopic
experiments,
control
and
DFT
calculations.
Язык: Английский
Catalytic Asymmetric Synthesis of β-Amino α-Tertiary Alcohol through Borrowing Hydrogen Amination
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
The
first
enantioconvergent
transition-metal-catalyzed
amination
of
racemic
α-tertiary
1,2-diols
providing
access
to
vicinal
β-amino
alcohols
is
disclosed.
iridium-catalyzed
reaction
proceeds
through
a
chiral
phosphoric
acid-mediated
borrowing
hydrogen
pathway
with
excellent
yields
and
enantioselectivities
for
range
amine
nucleophiles
1,2-diols.
An
array
were
obtained
high
(50
examples
up
91%
yield
99%
ee).
These
important
amino
alcohol
products
can
be
easily
converted
into
ligands
bioactive
skeletons.
Mechanistic
investigations
proposed
dynamic
kinetic
resolution
involving
imine
formation
then
reduction
as
the
enantiodetermining
step.
Язык: Английский