Unveiling the Mechanisms of Apoptosis Induction by Deep‐Sea‐Derived Polyketide‐Terpenoid Hybrids from Penicillium allii‐sativi: A Focus on Mitochondrial and mTOR Pathways

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(24), С. 3283 - 3292

Опубликована: Авг. 26, 2024

Comprehensive Summary A chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi MCCC 3A00580 resulted in discovery four new meroterpenoids ( 1 — 4 ) and one related known co‐metabolite 5 ). These showcase unique carbon skeletons featuring a common drimane sesquiterpene part with highly diverse polyketide units. Particularly, compound incorporates salicylic acid moiety while 2 possesses rare peroxide bridge part. The structures compounds were assigned by extensive spectroscopic analysis, quantum calculations, biogenetic considerations. Notably, 3 significantly blocked mTOR signaling pathway, resulting arrest cell cycle at G0‐G1 phase triggering mitochondrial apoptosis Hela cells. While previously reported macrophorin (MPA) effectively triggered death MDA‐MB‐231 cancer cells activating pathways involving receptors, mitochondria, mTOR, TNF.

Язык: Английский

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Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23

Phytochemistry, Год журнала: 2025, Номер 237, С. 114532 - 114532

Опубликована: Май 2, 2025

Язык: Английский

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Peunipyrone A, an Unexpected Highly Oxygenated γ-Pyrone with a 6/6/6/6/6 Pentacyclic Ring System from a Sponge-Derived Fungus Aspergillus peuniceus

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

A highly oxygenated γ-pyrone with an unprecedented carbon skeleton, peunipyrone (1), was isolated from the sponge-derived fungus Aspergillus peuniceus. Compound 1 features a unique fused 6/6/6/6/6 pentacyclic ring system. The chemical structure of compound elucidated by comprehensive spectroscopic techniques and single-crystal X-ray diffraction. plausible biosynthetic pathway proposed. promoted leukemic cell apoptosis increasing p53 expression.

Язык: Английский

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Chemical Constituents of Deep‐Sea Derived Fungus Pseudogymnoascus hyalinus and Their Ferroptosis Inhibitory Activity

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

ABSTRACT Four new polyketides including one indanone ( 1 ), isobenzofuranone 2 and two naphthoquinones 3 4 ) were isolated from the deep‐sea‐derived fungus Pseudogymnoascus hyalinus , along with 20 known compounds 5 – 24 ). The structures of established by comprehensive analyses their 1D 2D NMR, HRESIMS, as well TD‐DFT‐ECD. Compounds 6 10 displayed potent inhibitory effects against RSL3 induced ferroptosis EC 50 values 4.74, 1.55, 3.72 µM, respectively.

Язык: Английский

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Aspertaichamide B, a new anti-tumor prenylated indole alkaloid from the fungus Aspergillus japonicus TE-739D

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Сен. 25, 2024

Язык: Английский

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Nigenolides A–H, 13 new microperfuranones with ferroptosis inhibitory activity from the deep-sea-derived Aspergillus niger

Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107919 - 107919

Опубликована: Окт. 30, 2024

Язык: Английский

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Hot off the Press

Natural Product Reports, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as asperochone from

Язык: Английский

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