Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23

Phytochemistry, Journal Year: 2025, Volume and Issue: 237, P. 114532 - 114532

Published: May 2, 2025

Language: Английский

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Peunipyrone A, an Unexpected Highly Oxygenated γ-Pyrone with a 6/6/6/6/6 Pentacyclic Ring System from a Sponge-Derived Fungus Aspergillus peuniceus

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

A highly oxygenated γ-pyrone with an unprecedented carbon skeleton, peunipyrone (1), was isolated from the sponge-derived fungus Aspergillus peuniceus. Compound 1 features a unique fused 6/6/6/6/6 pentacyclic ring system. The chemical structure of compound elucidated by comprehensive spectroscopic techniques and single-crystal X-ray diffraction. plausible biosynthetic pathway proposed. promoted leukemic cell apoptosis increasing p53 expression.

Language: Английский

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Chemical Constituents of Deep‐Sea Derived Fungus Pseudogymnoascus hyalinus and Their Ferroptosis Inhibitory Activity

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

ABSTRACT Four new polyketides including one indanone ( 1 ), isobenzofuranone 2 and two naphthoquinones 3 4 ) were isolated from the deep‐sea‐derived fungus Pseudogymnoascus hyalinus , along with 20 known compounds 5 – 24 ). The structures of established by comprehensive analyses their 1D 2D NMR, HRESIMS, as well TD‐DFT‐ECD. Compounds 6 10 displayed potent inhibitory effects against RSL3 induced ferroptosis EC 50 values 4.74, 1.55, 3.72 µM, respectively.

Language: Английский

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Unveiling the Mechanisms of Apoptosis Induction by Deep‐Sea‐Derived Polyketide‐Terpenoid Hybrids from Penicillium allii‐sativi: A Focus on Mitochondrial and mTOR Pathways

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(24), P. 3283 - 3292

Published: Aug. 26, 2024

Comprehensive Summary A chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi MCCC 3A00580 resulted in discovery four new meroterpenoids ( 1 — 4 ) and one related known co‐metabolite 5 ). These showcase unique carbon skeletons featuring a common drimane sesquiterpene part with highly diverse polyketide units. Particularly, compound incorporates salicylic acid moiety while 2 possesses rare peroxide bridge part. The structures compounds were assigned by extensive spectroscopic analysis, quantum calculations, biogenetic considerations. Notably, 3 significantly blocked mTOR signaling pathway, resulting arrest cell cycle at G0‐G1 phase triggering mitochondrial apoptosis Hela cells. While previously reported macrophorin (MPA) effectively triggered death MDA‐MB‐231 cancer cells activating pathways involving receptors, mitochondria, mTOR, TNF.

Language: Английский

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Aspertaichamide B, a new anti-tumor prenylated indole alkaloid from the fungus Aspergillus japonicus TE-739D

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Sept. 25, 2024

Language: Английский

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Hot off the Press

Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as asperochone from

Language: Английский

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Nigenolides A–H, 13 new microperfuranones with ferroptosis inhibitory activity from the deep-sea-derived Aspergillus niger

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107919 - 107919

Published: Oct. 30, 2024

Language: Английский

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