Ligand-Controlled Copper-Catalyzed Regiodivergent Sulfonylation of Yne-Vinyl Allylic Esters with Sodium Sulfinates
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 2415 - 2423
Опубликована: Янв. 27, 2025
Язык: Английский
Copper-catalyzed Larock-type cyclization/debenzylation of yne-allylic esters with aliphatic amines
Rongkang Huang,
Yuepeng Lu,
Feng Xu
и другие.
Science China Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Copper-catalyzed remote asymmetric yne-allylic substitution: construction of thiazolone derivatives with adjacent chiral centers
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Herein,
we
report
a
highly
diastereo-
and
enantioselective
copper-catalyzed
remote
asymmetric
yne-allylic
substitution
of
esters
thiazolones.
Язык: Английский
Copper-catalyzed γ-selective yne-allylic substitution of vinyl ethynylethylene carbonates towards a formal [3 + 3] cycloaddition
Tetrahedron Letters,
Год журнала:
2025,
Номер
unknown, С. 155487 - 155487
Опубликована: Янв. 1, 2025
Язык: Английский
Synthesis of Axially Chiral N-Arylpyrroles through the Enantioselective Annulation of Yne-Allylic Esters with a Cooperative Copper-Squaramide Catalysis
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
We
present
a
strategy
involving
central-to-axial
chirality
conversion
for
the
construction
of
axially
chiral
N-arylpyrroles
via
cooperative
copper-squaramide-catalyzed
remote
propargylic
amination/ring
closure/rearomatization
cascade
from
yne-allylic
esters.
The
reaction
exhibits
excellent
chemical
efficiency
and
enantioselectivity,
good
conversion.
use
squaramide
as
cocatalyst
is
crucial
success.
Язык: Английский
Remote Copper-Catalyzed Atroposelective Synthesis of N–N Axially Chiral Compounds Bearing Minimally Different Alkyl Groups
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 25, 2025
Herein,
we
report
a
copper-catalyzed
remote
asymmetric
[4+1]
annulation/aromatization
between
yne-allylic
esters
and
N-aminoindoles,
providing
axially
chiral
N,N'-indolepyrroles
that
contain
sterically
comparable
ortho
substituents,
such
as
methyl
ethyl.
This
reaction
proceeds
smoothly
under
mild
conditions,
affording
products
with
excellent
regio-
enantioselectivities
while
demonstrating
broad
functional
group
compatibility.
The
synthetic
utility
of
this
approach
is
further
showcased
through
the
late-stage
modification
biologically
relevant
scaffolds.
Additionally,
preliminary
mechanistic
investigations
indicate
nucleophilic
substitution
enantio-determining
step.
Язык: Английский
Copper-catalyzed yne-allylic substitutions: concept and recent developments
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 2739 - 2775
Опубликована: Окт. 31, 2024
The
catalytic
(asymmetric)
allylation
and
propargylation
have
been
established
as
powerful
strategies
allowing
access
to
enantioenriched
α-chiral
alkenes
alkynes.
In
this
context,
combining
allylic
propargylic
substitutions
offers
new
opportunities
expand
the
scope
of
transition
metal-catalyzed
substitution
reactions.
Since
its
discovery
in
2022,
copper-catalyzed
yne-allylic
has
undergone
rapid
development
significant
progress
made
using
key
copper
vinyl
allenylidene
intermediates.
This
review
summarizes
developments
illustrates
influences
salt,
ligand,
pattern
substrate
on
regioselectivity
stereoselectivity.
Язык: Английский