Transformative Reactions in Nitroarene Chemistry: Advances in C–N Bond Cleavage, Skeletal Editing, and N–O Bond Utilization

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review aims to provide a comprehensive overview of the expanding utility nitroarenes and their potential for future applications in synthetic organic chemistry.

Язык: Английский

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Denitrative Functionalization of Nitroarenes: Recent Progress and Future Perspectives

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(45)

Опубликована: Авг. 27, 2024

Abstract Nitroarenes are fundamental feedstocks in the chemical industry. Their relatively inert C−NO 2 bond allows for late‐stage modifications of molecules and exhibits complete orthogonality to reactivity C‐halogen cross‐coupling reactions. The denitrative functionalization nitroarenes holds significant appeal due it avoids use aryl halides, thereby simplifying reaction steps improving atom step economy. Recent progress direct includes palladium‐catalyzed coupling, copper‐catalyzed as well metal‐free one‐pot functionalization. In this review, we provide a concise overview these advancements, detailing features mechanisms. This summary aims highlight versatility efficiency methodologies, offering insights into their potential applications inspiring further research promising area organic synthesis.

Язык: Английский

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Palladium-catalyzed carbon–carbon bond cleavage of primary alcohols: decarbonylative coupling of acetylenic aldehydes with haloarenes

RSC Advances, Год журнала: 2025, Номер 15(10), С. 7826 - 7831

Опубликована: Янв. 1, 2025

We report a novel method for the palladium-catalyzed cleavage of C–C bonds in primary alcohols, thereby enabling new route synthesis diarylacetylenes.

Язык: Английский

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Palladium-Catalyzed Coupling of Aryl Chlorides with Secondary Phosphines to Construct Unsymmetrical Tertiary Phosphines

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

The functionalization of the C-Cl bond in unactivated aryl chlorides under mild conditions presents a significant challenge. We disclose general protocol for constructing both partially and entirely unsymmetrical tertiary phosphines through Pd/keYPhos-catalyzed coupling with secondary conditions. reaction exhibits excellent functional group tolerance broad substrate scopes. Furthermore, rapid synthesis ligands luminescent compound sTPPs, alongside gram-scale systhesis, demonstrates practical applicability this method.

Язык: Английский

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Transition-metal-free Photochemical Reductive Denitration of Nitroarenes

Chemical Communications, Год журнала: 2024, Номер 60(93), С. 13754 - 13757

Опубликована: Янв. 1, 2024

A mild, transition-metal-free photochemical process for reductive denitration of nitroarenes with broad functional group compatibility has been developed.

Язык: Английский

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Palladium-catalyzed N-arylation of (hetero)aryl chlorides with pyrroles and their analogues

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

A practical method for N -arylation of N–H heteroarenes with aryl chlorides through Pd/keYPhos catalyzed selective cleavage the Ar–Cl bond under mild conditions has been developed.

Язык: Английский

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