Cu-Catalyzed Relay Functionalization of Alkenes: Diverse Synthesis of Diazidated Quinazolinones and Polycyclic Imidazoles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
A
Cu-catalyzed
relay
process
for
the
preparation
of
diazidated
quinazolinone
and
polycyclic
imidazole
derivatives
in
which
readily
available
alkene-tethered
substrates
undergo
an
addition/cyclization/C(sp3)–H
functionalization
alkene
sequences
with
high
efficiency
is
described.
Various
functionalized
N-heteropolycyclic
compounds
were
prepared
good
yields
a
broad
substrate
scope.
Moreover,
direct
azidation
α-C(sp3)–H
bond
corresponding
N-heterocycles
has
been
demonstrated
on
basis
mechanistic
studies,
provide
alternative
late-stage
approach
derivatization
N-heterocyclic
scaffolds.
Язык: Английский
Thiolative Annulation of N-Benzyl-N-cyanopropiolamides Leading to Divergent Synthesis of Pyrroloquinazolin-1-ones and Maleimides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
An
unprecedented
successive
radical-promoted
thiolative
annulation/Pd-catalyzed
C-H
amination
of
N-benzyl-N-cyanopropiolamides
to
access
pyrrolo[2,1-b]quinazolin-1(9H)-ones
in
a
one-pot
manner
is
described.
Moreover,
altering
the
step
with
oxidation
(reagent
switch)
offered
maleimides
from
same
set
readily
accessible
precursors.
Both
transformations
display
versatility
across
wide
range
substrates,
enabling
efficient
various
functionalized
quinazolin-1-ones
and
good
yields.
Язык: Английский
Visible-light-promoted azidation/arylation of unactivated alkenes with Togni-N3 via electrondonor–acceptor complexes
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
A
visible-light-promoted
azidation/arylation
of
unactivated
alkenes
with
Togni-N
3
toward
a
series
azidated
pyrrolo[1,2-
]indoles
via
an
EDA
complex
as
the
key
intermediate.
Язык: Английский