Cu-Catalyzed Relay Functionalization of Alkenes: Diverse Synthesis of Diazidated Quinazolinones and Polycyclic Imidazoles

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

A Cu-catalyzed relay process for the preparation of diazidated quinazolinone and polycyclic imidazole derivatives in which readily available alkene-tethered substrates undergo an addition/cyclization/C(sp3)–H functionalization alkene sequences with high efficiency is described. Various functionalized N-heteropolycyclic compounds were prepared good yields a broad substrate scope. Moreover, direct azidation α-C(sp3)–H bond corresponding N-heterocycles has been demonstrated on basis mechanistic studies, provide alternative late-stage approach derivatization N-heterocyclic scaffolds.

Language: Английский

Visible-light-promoted azidation/arylation of unactivated alkenes with Togni-N3 via electrondonor–acceptor complexes

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

A visible-light-promoted azidation/arylation of unactivated alkenes with Togni-N 3 toward a series azidated pyrrolo[1,2- ]indoles via an EDA complex as the key intermediate.

Language: Английский