Palladium-Catalyzed Cascade Carbonylation Reaction To Construct Ester Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
We
have
developed
a
palladium-catalyzed
ester
carbonylation
reaction
that
enables
the
synthesis
of
ester-substituted
benzofuran
derivatives
in
single
step
through
introduction
alkyl
halides
undergoing
situ
hydrolysis
and
alkynyl
aryl
iodides.
This
method
demonstrates
broad
applicability
to
both
primary
secondary
while
maintaining
excellent
functional
group
compatibility
under
low
palladium
loading
conditions.
Notably,
this
strategy
significantly
expands
scope
reactions.
Язык: Английский
Tandem [4C + 2C] cyclization reaction of α-acetyl-α-oxo ketene dithioacetals and acrylonitrile: A straightforward synthesis of polysubstituted cyclohex-3-enones
Synthetic Communications,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Апрель 26, 2025
Язык: Английский
Acid-Regulated Selective Synthesis of Benzofuran Derivatives via Single-Component BDA Retro-Aldol/Michael Addition Cascade and [4 + 2] Cycloaddition Reactions
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
The
acid-controlled
single-component
retro-aldol/Michael
addition
cascade
reaction
and
[4
+
2]
cycloaddition
of
benzofuran-derived
azadienes
(BDAs)
are
reported
for
the
first
time.
Under
conditions
trifluoromethanesulfonic
acid
as
catalyst
with
water,
BDAs
initiate
retro-aldol
reaction,
followed
by
a
1,4-Michael
addition,
yielding
(arylmethylene)bis(dibenzofuran)
products
excellent
yields
broad
substrate
applicability.
This
represents
application
in
reaction.
In
contrast,
absence
water
boron
trifluoride
etherate
catalyst,
undergo
constructing
spiro[benzofuran-2,3'-benzofuro[3,2-b]pyridine]
framework
high
diastereoselectivity.
method
features
mild
atom
economy,
provides
new
approach
benzofuran
scaffold
derivatives.
Язык: Английский