Direct Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
direct
cross-couplings
of
aryl
nonaflates
with
bromides
could
be
successfully
accomplished
by
utilizing
nickel
as
the
catalyst,
magnesium
metal
mediator,
and
lithium
chloride
additive.
reactions
proceeded
efficiently
in
THF
at
room
temperature
to
produce
desired
biaryls
moderate
good
yields,
showing
both
a
reasonable
substrate
scope
functional
group
tolerance.
Additionally,
an
equally
performance
realized
when
reaction
was
subjected
scale-up
synthesis.
Preliminary
study
suggested
that
presumably
proceeds
through
situ
formation
arylmagnesium
reagent
key
intermediate.
Язык: Английский
Magnesium-Mediated Three-Component Reductive Cross-Couplings of Aryl Aldehydes, Aryl Bromides, and Aryl 2-Pyridyl Esters: An Efficient Synthesis of Diarylmethanol Esters
Tetrahedron,
Год журнала:
2025,
Номер
unknown, С. 134558 - 134558
Опубликована: Фев. 1, 2025
Язык: Английский
Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
We
presented
a
highly
efficient
palladium-catalyzed
site-selective
C-H
sulfonylation
reaction
via
aryl
thianthrenium
salts.
By
utilizing
readily
available
and
cost-effective
arenes
along
with
sodium
sulfinates,
we
achieved
the
C(sp2)-S
cross-coupling
high
efficiency,
establishing
dependable
method
for
synthesizing
diarylsulfones
satisfactory
yields.
This
exhibits
excellent
tolerance
toward
functional
groups,
scalability,
synthesis
or
late-stage
functionalization
of
bioactive
molecules,
making
it
valuable
tool
drug
modifications.
Язык: Английский
Iron-Mediated One-Pot Dehydroxylative Cross-Electrophile Coupling of Alcohol with Disulfide for Thioether Synthesis by Using TCT as a Hydroxyl-Activating Agent
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
An
efficient
dehydroxythiolation
between
alcohols
and
disulfides
using
the
widely
abundant
cheapest
iron
as
a
reaction
mediator
was
developed.
The
one-pot
thiolation
proceeded
effectively
via
C-O
bond
activation
with
aid
of
cyanuric
chloride
(TCT)
hydroxyl-activating
agent
to
give
corresponding
thioethers
in
modest
excellent
yields,
displaying
both
wide
substrate
scope
(applicable
benzyl
alcohol,
allyl
primary
alkyl
alcohol)
good
functional
group
tolerance.
In
addition,
diselenide
also
proven
be
an
appropriate
for
protocol,
could
subjected
scale-up
synthesis.
Preliminary
mechanistic
examination
revealed
that
transiently
formed
TCT-derived
ether
A,
which
is
generated
situ
TCT
possibly
serves
pivotal
intermediate
cross-electrophile
thioetherification.
Язык: Английский
Palladium-Catalyzed Decarboxylative Cross-Couplings of Zinc Polyfluorobenzoates with Aryl 2-Pyridyl Esters for Accessing Polyfluorinated Aryl Ketones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
An
efficient
decarboxylative
cross-coupling
of
zinc
polyfluorobenzoate
with
aryl
2-pyridyl
ester
under
palladium
catalysis,
which
enabled
the
convenient
access
to
valuable
polyfluorinated
ketones,
was
developed.
The
reactions
proceeded
effectively
give
an
array
ketones
in
moderate
excellent
yields
a
reasonable
substrate
scope
and
broad
functional
group
tolerance.
In
addition,
one-pot
reaction
use
situ
formed
commencing
from
polyfluorobenzoic
acid
Zn(OH)2
could
be
accomplished
as
well
step-economical
fashion.
Moreover,
coupling
protocol
also
successfully
subjected
scale-up
synthesis
readily
applied
late-stage
functionalization
biologically
active
complex
molecules.
Язык: Английский
Iron‐Mediated Desulfonylative Cross‐Electrophile Couplings of Heteroaryl Sulfones with Thiosulfonates for Efficient Synthesis of Heteroaryl Sulfides
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Comprehensive
Summary
A
desulfonylative
thiolation
between
heteroaryl
sulfones
and
thiosulfonates
for
the
efficient
synthesis
of
sulfides
was
developed.
The
cross‐electrophile
couplings
proceeded
effectively
via
old
C–SO
2
bond
cleavage
new
C–S
formation
in
presence
cheapest
widely
available
iron
powder
as
mediator
under
transition
metal
catalyst‐free
conditions,
leading
to
a
wide
array
derived
from
benzo[
d
]thiazole,
]oxazole,
thiazole,
1,3,4‐thiadiazole,
1
H
‐tetrazole
modest
excellent
yields.
In
addition,
reaction
exhibited
good
functional
group
compatibility,
protocol
could
also
be
applicable
use
selenosulfonate
substrate
subjected
scale‐up
with
equal
ease.
Notably,
unreacted
readily
recovered
after
by
resorting
attracting
property
magnetic
stir
bar
iron.
Язык: Английский
Photoinduced Cu‐Catalyzed C2‐H Functionalization of Azoles using Aryl Thianthrenium Salts
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Abstract
Development
of
a
mild
approach
for
the
highly
efficient
synthesis
2‐aryl
azoles,
which
are
typically
synthesized
using
high
temperature,
ligands
and
preactivated
substrates,
is
desirable.
Here,
we
report
photo‐induced
Cu‐catalyzed
C−H/C−H
cross‐coupling
to
obtain
C2‐functionalized
azoles
aryl
thianthrenium
salt
(Ar‐TTs).
The
reaction
exhibits
broad
substrate
scope
an
excellent
functional
group
compatibility
serves
as
ideal
strategy
late‐stage
functionalization
pharmaceuticals.
Additionally,
this
method
enables
azole‐based
polycyclic
compounds.
Язык: Английский