Photoinduced Cu‐Catalyzed C2‐H Functionalization of Azoles using Aryl Thianthrenium Salts DOI Open Access
Zhenhui Wang, Jinfang Wang,

Zhenning Yang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Development of a mild approach for the highly efficient synthesis 2‐aryl azoles, which are typically synthesized using high temperature, ligands and preactivated substrates, is desirable. Here, we report photo‐induced Cu‐catalyzed C−H/C−H cross‐coupling to obtain C2‐functionalized azoles aryl thianthrenium salt (Ar‐TTs). The reaction exhibits broad substrate scope an excellent functional group compatibility serves as ideal strategy late‐stage functionalization pharmaceuticals. Additionally, this method enables azole‐based polycyclic compounds.

Language: Английский

Direct Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis DOI
Hao Xu,

Jia-Wen Jing,

Yubing Chen

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The direct cross-couplings of aryl nonaflates with bromides could be successfully accomplished by utilizing nickel as the catalyst, magnesium metal mediator, and lithium chloride additive. reactions proceeded efficiently in THF at room temperature to produce desired biaryls moderate good yields, showing both a reasonable substrate scope functional group tolerance. Additionally, an equally performance realized when reaction was subjected scale-up synthesis. Preliminary study suggested that presumably proceeds through situ formation arylmagnesium reagent key intermediate.

Language: Английский

Citations

1
Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones DOI
Chunjie Ni, Jinping Liu,

Xiaoxu Zhang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

We presented a highly efficient palladium-catalyzed site-selective C-H sulfonylation reaction via aryl thianthrenium salts. By utilizing readily available and cost-effective arenes along with sodium sulfinates, we achieved the C(sp2)-S cross-coupling high efficiency, establishing dependable method for synthesizing diarylsulfones satisfactory yields. This exhibits excellent tolerance toward functional groups, scalability, synthesis or late-stage functionalization of bioactive molecules, making it valuable tool drug modifications.

Language: Английский

Citations

0
Magnesium-Mediated Three-Component Reductive Cross-Couplings of Aryl Aldehydes, Aryl Bromides, and Aryl 2-Pyridyl Esters: An Efficient Synthesis of Diarylmethanol Esters DOI
Xiaowei Han,

Yuan-Shuai Wu,

Tie Wu

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134558 - 134558

Published: Feb. 1, 2025

Language: Английский

Citations

0
Photoinduced Cu‐Catalyzed C2‐H Functionalization of Azoles using Aryl Thianthrenium Salts DOI Open Access
Zhenhui Wang, Jinfang Wang,

Zhenning Yang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Development of a mild approach for the highly efficient synthesis 2‐aryl azoles, which are typically synthesized using high temperature, ligands and preactivated substrates, is desirable. Here, we report photo‐induced Cu‐catalyzed C−H/C−H cross‐coupling to obtain C2‐functionalized azoles aryl thianthrenium salt (Ar‐TTs). The reaction exhibits broad substrate scope an excellent functional group compatibility serves as ideal strategy late‐stage functionalization pharmaceuticals. Additionally, this method enables azole‐based polycyclic compounds.

Language: Английский

Citations

0