Palladium-catalyzed intermolecular formal [3+2] cyclization/C-H alkylation of polyfluoroarenes
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
sequential
three-component
intermolecular
carbopalladation/Heck
cyclization/intermolecular
C–H
bond
functionalization
for
versatile
alkylated
polyfluoroarenes
containing
an
indene
skeleton
is
presented.
Язык: Английский
Palladium-Catalyzed Domino Heck/Decarboxylative Cyanomethylation of Indoles and Alkenes with Cyanoacetate Salts
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
A
palladium-catalyzed
reaction
of
indoles
with
cyanoacetate
salts
enables
the
synthesis
2,6-disubstituted
indolines
via
tandem
dearomatization/decarboxylative
cyanomethylation.
Remarkably,
this
is
first
example
indole
difunctionalization
at
C2
and
C6
positions.
Moreover,
methodology
extends
to
cyclization/decarboxylative
cyanomethylation
aryl
halide-tethered
alkenes.
Язык: Английский
One-Step Synthesis of Indoloquinoline Alkaloids via the Pd-Catalyzed Larock/Ligand-Accelerated C–H Activation Cascade Reaction
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Pd-catalyzed
cascade
annulation
of
2-iodoanilines
with
N,3-diphenylpropiolamides
was
achieved,
which
afforded
a
series
indolo[2,3-c]quinolinones
good
yields
and
functional
group
compatibility.
Previously,
the
retro-synthetic
routine
for
indolo[2,3-c]quinolinone
skeleton
has
often
involved
intramolecular
disconnection
C(sp2)-C(sp2)
bond
at
variable
positions,
necessitates
construction
an
indole
or
quinoline
reactant
multiple
pre-set
functionalities.
Meanwhile,
using
C-H
activation
strategy
to
construct
indoloquinoline
is
limited
cases
in
must
be
bearing
nonremovable
directing
group.
Therefore,
circumvent
these
limitations,
we
herein
report
Larock/ligand-accelerated
one-pot
fashion.
This
transformation
2-amidoindole
relies
on
Larock
reaction,
then
forms
C-N
afford
via
ligand-enabled
activation.
Язык: Английский