One-Step Synthesis of Indoloquinoline Alkaloids via the Pd-Catalyzed Larock/Ligand-Accelerated C–H Activation Cascade Reaction DOI
Chien‐Huang Wu, Jinjian Li,

Hongyu Wang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Pd-catalyzed cascade annulation of 2-iodoanilines with N,3-diphenylpropiolamides was achieved, which afforded a series indolo[2,3-c]quinolinones good yields and functional group compatibility. Previously, the retro-synthetic routine for indolo[2,3-c]quinolinone skeleton has often involved intramolecular disconnection C(sp2)-C(sp2) bond at variable positions, necessitates construction an indole or quinoline reactant multiple pre-set functionalities. Meanwhile, using C-H activation strategy to construct indoloquinoline is limited cases in must be bearing nonremovable directing group. Therefore, circumvent these limitations, we herein report Larock/ligand-accelerated one-pot fashion. This transformation 2-amidoindole relies on Larock reaction, then forms C-N afford via ligand-enabled activation.

Language: Английский

Palladium-catalyzed intermolecular formal [3+2] cyclization/C-H alkylation of polyfluoroarenes DOI
Zhongyao Jiang, Chenglin Liu,

Mingxia Wu

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A sequential three-component intermolecular carbopalladation/Heck cyclization/intermolecular C–H bond functionalization for versatile alkylated polyfluoroarenes containing an indene skeleton is presented.

Language: Английский

Citations

0
Palladium-Catalyzed Domino Heck/Decarboxylative Cyanomethylation of Indoles and Alkenes with Cyanoacetate Salts DOI

Ping‐Xin Zhou,

Yang Liu, Mengjuan Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

A palladium-catalyzed reaction of indoles with cyanoacetate salts enables the synthesis 2,6-disubstituted indolines via tandem dearomatization/decarboxylative cyanomethylation. Remarkably, this is first example indole difunctionalization at C2 and C6 positions. Moreover, methodology extends to cyclization/decarboxylative cyanomethylation aryl halide-tethered alkenes.

Language: Английский

Citations

0
One-Step Synthesis of Indoloquinoline Alkaloids via the Pd-Catalyzed Larock/Ligand-Accelerated C–H Activation Cascade Reaction DOI
Chien‐Huang Wu, Jinjian Li,

Hongyu Wang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Pd-catalyzed cascade annulation of 2-iodoanilines with N,3-diphenylpropiolamides was achieved, which afforded a series indolo[2,3-c]quinolinones good yields and functional group compatibility. Previously, the retro-synthetic routine for indolo[2,3-c]quinolinone skeleton has often involved intramolecular disconnection C(sp2)-C(sp2) bond at variable positions, necessitates construction an indole or quinoline reactant multiple pre-set functionalities. Meanwhile, using C-H activation strategy to construct indoloquinoline is limited cases in must be bearing nonremovable directing group. Therefore, circumvent these limitations, we herein report Larock/ligand-accelerated one-pot fashion. This transformation 2-amidoindole relies on Larock reaction, then forms C-N afford via ligand-enabled activation.

Language: Английский

Citations

0