Photoinduced Cascade Synthesis of Oxindoles and Isoquinolinediones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Herein,
we
developed
alkyl
radical
generation
from
C(sp3)–H
bonds
of
alkanes
via
a
photoinduced
HAT-process
without
employing
an
external
metal,
photocatalyst,
and
organic
peroxide.
The
generated
participates
in
addition
cascade
cyclization
N-arylacrylamides/N-acryloyl
benzamides
to
deliver
structurally
diverse
valuable
functionalized
oxindoles
isoquinolinediones
moderate
good
yields.
Preliminary
mechanistic
studies
indicated
the
aryl
through
homolytic
cleavage
Ar–I
direct
photoexcitation
iodide.
Язык: Английский
Bifunctional Ionic Liquids Induced Electrochemical C–H Arylation of Quinoxalin(on)es with Aryltriazenes
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
An
efficient
bifunctional
ionic-liquid-induced
electrochemical
C-H
arylation
of
quinoxalin(on)es
with
aryltriazenes
has
been
developed.
The
reaction
utilizes
as
stable
reagents
and
ionic
liquids
promoter
electrolyte.
Various
arylated
quinoxalin-2(1H)-ones,
quinoxaline
2-methyldibenzo[f,h]quinoxaline
were
assembled
in
modest
to
excellent
yields
under
mild,
metal-
oxidant-free
conditions.
developed
protocol
features
simple
operation,
good
functional
group
tolerance,
selectivity,
product
derivatization,
practical
gram-scale
synthesis
batch
continuous-flow
processes.
Язык: Английский