Photoinduced Cascade Synthesis of Oxindoles and Isoquinolinediones

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Herein, we developed alkyl radical generation from C(sp3)–H bonds of alkanes via a photoinduced HAT-process without employing an external metal, photocatalyst, and organic peroxide. The generated participates in addition cascade cyclization N-arylacrylamides/N-acryloyl benzamides to deliver structurally diverse valuable functionalized oxindoles isoquinolinediones moderate good yields. Preliminary mechanistic studies indicated the aryl through homolytic cleavage Ar–I direct photoexcitation iodide.

Language: Английский

Bifunctional Ionic Liquids Induced Electrochemical C–H Arylation of Quinoxalin(on)es with Aryltriazenes

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

An efficient bifunctional ionic-liquid-induced electrochemical C-H arylation of quinoxalin(on)es with aryltriazenes has been developed. The reaction utilizes as stable reagents and ionic liquids promoter electrolyte. Various arylated quinoxalin-2(1H)-ones, quinoxaline 2-methyldibenzo[f,h]quinoxaline were assembled in modest to excellent yields under mild, metal- oxidant-free conditions. developed protocol features simple operation, good functional group tolerance, selectivity, product derivatization, practical gram-scale synthesis batch continuous-flow processes.

Language: Английский