Sc(OTf)3-Catalyzed Diastereoselective Hydroxyheteroarylation of C–C σ-Bonds of Bicyclo[1.1.0]butanes with Azaheterocyclic N-Oxides DOI
Jiang Wang, Jiajia Liu, Chenwei Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

A mild and atom-economical reaction for the Sc(OTf)3-catalyzed 1,3-hydroxyheteroarylation of bicyclo[1.1.0]butanes (BCBs) with azaaryl N-oxides via an unprecedented [4π+2σ] cycloaddition/ring-opening process is described. This transformation provides a novel strategy highly regio- diastereoselective preparation azaheterocycle-tethered 1,1,3,3-tetrasubstituted cyclobutane derivatives offers broad substrate scope high yields.

Language: Английский

Sc(OTf)3-Catalyzed Diastereoselective Hydroxyheteroarylation of C–C σ-Bonds of Bicyclo[1.1.0]butanes with Azaheterocyclic N-Oxides DOI
Jiang Wang, Jiajia Liu, Chenwei Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

A mild and atom-economical reaction for the Sc(OTf)3-catalyzed 1,3-hydroxyheteroarylation of bicyclo[1.1.0]butanes (BCBs) with azaaryl N-oxides via an unprecedented [4π+2σ] cycloaddition/ring-opening process is described. This transformation provides a novel strategy highly regio- diastereoselective preparation azaheterocycle-tethered 1,1,3,3-tetrasubstituted cyclobutane derivatives offers broad substrate scope high yields.

Language: Английский

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