Visible-Light-Induced C (sp³)–H Functionalization of Tosylhydrazones: Synthesis of Polysubstituted Pyrroles under Metal-Free Conditions

The Journal of Organic Chemistry, Год журнала: 2018, Номер 83(16), С. 9412 - 9421

Опубликована: Июль 19, 2018

Iodine catalyzed C (sp3)-H functionalization of tosylhydrazones with β-enamino esters under visible light irradiation for the synthesis trisubstituted pyrroles has been described. The present method is also applicable to α- substituted yield tetra-substituted pyrroles.

Язык: Английский

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I₂-Promoted Multicomponent Dicyclization and Ring-Opening Sequences: Direct Synthesis of Benzo[e][1,4]diazepin-3-ones via Dual C–O Bond Cleavage

Organic Letters, Год журнала: 2019, Номер 21(18), С. 7504 - 7508

Опубликована: Сен. 5, 2019

A novel and efficient formal [4 + 2+1] annulation of aryl methyl ketones 2-aminobenzyl alcohols for the synthesis benzo[e][1,4]diazepin-3-ones is reported. This reaction successfully affords diverse seven-membered ring lactams via dual C–O bond cleavage. preliminary mechanistic study showed that a multicomponent dicyclization ring-opening sequence might occur, with introduction sulfide proposed as last step. strategy mild conditions broad substrate scope has potential applications in chemistry medicine.

Язык: Английский

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NaHS·nH₂O-induced umpolung: the synthesis of 2-acyl-3-aminoindoles from aryl methyl ketones and 2-aminobenzonitriles

Chemical Communications, Год журнала: 2018, Номер 54(90), С. 12730 - 12733

Опубликована: Янв. 1, 2018

An efficient method for constructing 2-acyl-3-aminoindoles from methyl ketones and 2-aminobenzonitriles is described, in which NaHS·nH₂O used as a novel umpolung reagent the first time organic synthesis.

Язык: Английский

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Reactions involving aryl methyl ketone and molecular iodine: a powerful tool in the one-pot synthesis of heterocycles

New Journal of Chemistry, Год журнала: 2021, Номер 45(44), С. 20486 - 20518

Опубликована: Янв. 1, 2021

The preparation of heterocyclic compounds has attracted great attention in organic chemistry because their extensive application the field bioactive molecules, materials science, and natural products.

Язык: Английский

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Hypervalent Iodine(III)‐Catalysis Using Sulfoxide Oxidant for the Dehydrogenative Cycloisomerization‐Arylation Reaction of 2‐Propargyl 1,3‐Dicarbonyl Compounds

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(8)

Опубликована: Фев. 7, 2024

Abstract We report herein an unprecedented hypervalent iodine(III)‐catalysis using the activated sulfoxide. Since present catalytic systems promote dehydrogenative cycloisomerization‐arylation reaction of 2‐propargyl 1,3‐dicarbonyl compounds with aromatics, this also provides one few methods for iodine(III)‐catalyzed intermolecular carbon‐carbon bond formation aromatics.

Язык: Английский

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