Titanium catalysis for the synthesis of fine chemicals – development and trends

Chemical Society Reviews, Год журнала: 2020, Номер 49(19), С. 6947 - 6994

Опубликована: Янв. 1, 2020

Atlas as a Titan(ium) is holding the earth-abundant chemistry world. Titanium second most abundant transition metal, key player in important industrial processes (e.g. polyethylene) and shows much promise for diverse applications future.

Язык: Английский

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Anti-Markovnikov Intermolecular Hydroamination of Alkenes and Alkynes: A Mechanistic View

Chemical Reviews, Год журнала: 2023, Номер 123(15), С. 9139 - 9203

Опубликована: Июль 5, 2023

Hydroamination, the addition of an N–H bond across a C–C multiple bond, is reaction with great synthetic potential. Important advances have been made in last decades concerning catalysis these reactions. However, controlling regioselectivity amine toward formation anti-Markovnikov products (addition to less substituted carbon) still remains challenge, particularly intermolecular hydroaminations alkenes and alkynes. The goal this review collect systems which hydroamination terminal alkynes has achieved. focus will be placed on mechanistic aspects such reactions, discern step at decided unravel factors that favor regioselectivity. In processes entailing direct alternative pathways, involving several reactions accomplish (formal processes), also discussed review. catalysts gathered embrace most metal groups Periodic Table. Finally, section discussing radical-mediated metal-free approaches, as well heterogeneous catalyzed processes, included.

Язык: Английский

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Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

The Chemical Record, Год журнала: 2023, Номер 23(12)

Опубликована: Ноя. 27, 2023

Cancer stands as a serious malady, posing substantial risks to human well-being and survival. This underscores the paramount necessity explore investigate novel antitumor medications. Nitrogen-containing compounds, especially those derived from natural sources, form highly significant category of agents. Among these, agents with six-membered aromatic nitrogen heterocycles have consistently attracted attention chemists pharmacologists. Accordingly, we present comprehensive summary synthetic strategies clinical implications these compounds in this review. entails an in-depth analysis synthesis pathways for pyridine, quinoline, pyrimidine, quinazoline. Additionally, historical progression, targets, mechanisms action, effectiveness small molecule inhibitors possessing structural features.

Язык: Английский

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N-Silylamines in catalysis: synthesis and reactivity

Chemical Communications, Год журнала: 2022, Номер 58(66), С. 9174 - 9189

Опубликована: Янв. 1, 2022

Efficient catalytic routes to prepare electronically and sterically distinct silylamine building blocks for the step-economic synthesis of amines N-heterocycles.

Язык: Английский

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One‐Pot Multicomponent Reaction: A Highly Versatile Strategy for the Construction of Valuable Nitrogen‐Containing Heterocycles

ChemistrySelect, Год журнала: 2022, Номер 7(33)

Опубликована: Сен. 1, 2022

Abstract A large portion of the chemical subspace is multi‐component reaction (MCR). Apart from Domino reactions, MCR one most promising routes for one‐pot synthesis. Thus, derived product can be considered as a synthetic hub to vast diversity novel cyclic or acyclic compounds. Heterocyclic moiety such naphthyridines, quinolines, dihydropyridines (DHPs), quinazolines, pyrimidines, imidazoles, diazepines, and spiro‐heterocycles are widely recognized in clinical evaluation. Because their relevant significance, literature exists accomplish synthesis these biologically important Therefore, this review highlights last ten years developments heterocyclic moieties which by industry addition academia.

Язык: Английский

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A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: a one-step synthesis of the monoterpene natural product, (−)-actinidine

Chemical Communications, Год журнала: 2019, Номер 55(22), С. 3270 - 3273

Опубликована: Янв. 1, 2019

A simple and modular one-step synthesis of diversely substituted pyridines from readily available α,β-unsaturated carbonyl compounds propargylic amines has been developed. The present protocol a broad substrate scope allows access to multi-substituted with select control the substitution pattern under mild metal-free conditions. reaction involves imine formation followed by concomitant cyclization through an allenyl intermediate afford in excellent yields, water as sole by-product. This strategy is also suitable for functionalization natural products or other advanced intermediates having functionality. utility was showcased monoterpene alkaloid, (-)-actinidine, ant-associated iridoid.

Язык: Английский

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Ten years of progress in the synthesis of six-membered N-heterocycles from alkynes and nitrogen sources

Tetrahedron, Год журнала: 2019, Номер 76(4), С. 130876 - 130876

Опубликована: Дек. 10, 2019

Язык: Английский

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Multicomponent syntheses of 5- and 6-membered aromatic heterocycles using group 4–8 transition metal catalysts

Chemical Science, Год журнала: 2021, Номер 12(28), С. 9574 - 9590

Опубликована: Янв. 1, 2021

In this Perspective, we discuss recent syntheses of 5- and 6-membered aromatic heterocycles via multicomponent reactions (MCRs) catalyzed by group 4–8 transition metals, with a focus on common mechanisms synthetic strategies across the series.

Язык: Английский

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Alkyne Carboamination with Imines Catalyzed by [py₂TiCl₂N(p-tol)]₂

Organometallics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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α,β‐Unsaturated Aldehydes as C‐Building Blocks in the Synthesis of Pyridines, 1,4‐Dihydropyridines and 1,2‐Dihydropyridines

Asian Journal of Organic Chemistry, Год журнала: 2019, Номер 8(8), С. 1207 - 1226

Опубликована: Июнь 11, 2019

Abstract N ‐heterocycles are ubiquitous structural units in a variety of biologically active compounds, pharmaceutical preparations, and natural complex molecules. Thousands original scientific papers published annually on various aspects the formation nitrogenous heterocycles study their chemical biological properties. Among them, synthesis pyridines dihydrogenated derivatives attracts attention chemists, which develop synthetic techniques, including those ones based α,β‐unsaturated aldehydes. The minireview summarizes highlights recent advancements construction pyridines, 1,2‐dihydropyridines, 1,4‐dihydropyridines from transformations 2‐alkenals, covering publications last five years.

Язык: Английский

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