tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives

Organic Letters, Год журнала: 2019, Номер 21(18), С. 7375 - 7379

Опубликована: Авг. 29, 2019

A tert-butyl nitrite (TBN)-mediated synthesis of fluorinated O-alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. variety halodifluorinated compounds were found compatible, delivering desired products in moderate to excellent yields. This transformation features a simple operation, can be done air, and involve radicals. protocol represents straightforward approach access various derivatives.

Язык: Английский

---

Isocyanide-Based Multicomponent Reaction: Cascade α-Acyloxylation/Carboxamidation and [3 + 1+1] Cyclization of I^(III)/S^(VI)-Ylides

Organic Letters, Год журнала: 2024, Номер 26(29), С. 6263 - 6268

Опубликована: Июль 12, 2024

A metal-free cascade of α-acyloxylation/carboxamidation I(III)/S(VI)-ylides, carboxylic acids, and isonitriles via a Passerini-like multicomponent reaction is reported. Unexpectedly, [3 + 1+1] cyclization involving I(III)/S(VI)-ylides two molecules ethyl isocyanoacetate was observed. The strategy allows for the synthesis unsymmetrical α,α-disubstituted ketones functionalized pyrroles with up to 99% yield wide substrate compatibility. Notably, procedure has been extended late-stage modification drugs natural products, offering an elegant complement classic Passerini reaction.

Язык: Английский

---

Electron Donor–Acceptor Complex-Enabled Autoinductive Conversion of Acylnitromethanes to Acylnitrile Oxides in a Photochemical Machetti–De Sarlo Reaction: Synthesis of 5-Substituted 3-Acylisoxazoles

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

A photochemical Machetti-De Sarlo reaction has been developed for preparing 5-substituted 3-acylisoxazoles from acylnitromethanes and terminal alkynes. This protocol utilizes an innovative electron donor-acceptor complex, generated

Язык: Английский

---

Modular Synthesis of Divergent Thiofunctionalized Sulfoxonium Ylides

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A metal-free protocol for the modular synthesis of diverse α-thiofunctionalized-α′-carbonyl sulfoxonium ylides from sulfoxonium–iodonium hybrid (I (III) /S (VI) -ylides) has been achieved.

Язык: Английский

---

Isoxazole compounds: unveiling the synthetic strategy, In-silico SAR & Toxicity studies and future perspective as PARP inhibitor in cancer therapy

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116898 - 116898

Опубликована: Сен. 24, 2024

Язык: Английский

---