Cited by Isoxazole compounds: unveiling the synthetic strategy, In-silico SAR & Toxicity studies and future perspective as PARP inhibitor in cancer therapy

tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives DOI

Xingxing Ma,

Qiuling Song

Organic Letters, Journal Year: 2019, Volume and Issue: 21(18), P. 7375 - 7379

Published: Aug. 29, 2019

A tert-butyl nitrite (TBN)-mediated synthesis of fluorinated O-alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. variety halodifluorinated compounds were found compatible, delivering desired products in moderate to excellent yields. This transformation features a simple operation, can be done air, and involve radicals. protocol represents straightforward approach access various derivatives.

Language: Английский

Citations

Isocyanide-Based Multicomponent Reaction: Cascade α-Acyloxylation/Carboxamidation and [3 + 1+1] Cyclization of I^(III)/S^(VI)-Ylides DOI

Dan‐Ting Shen,

Wen-Rong Wu,

Wen‐Xuan Zou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(29), P. 6263 - 6268

Published: July 12, 2024

A metal-free cascade of α-acyloxylation/carboxamidation I(III)/S(VI)-ylides, carboxylic acids, and isonitriles via a Passerini-like multicomponent reaction is reported. Unexpectedly, [3 + 1+1] cyclization involving I(III)/S(VI)-ylides two molecules ethyl isocyanoacetate was observed. The strategy allows for the synthesis unsymmetrical α,α-disubstituted ketones functionalized pyrroles with up to 99% yield wide substrate compatibility. Notably, procedure has been extended late-stage modification drugs natural products, offering an elegant complement classic Passerini reaction.

Language: Английский

Citations

Electron Donor–Acceptor Complex-Enabled Autoinductive Conversion of Acylnitromethanes to Acylnitrile Oxides in a Photochemical Machetti–De Sarlo Reaction: Synthesis of 5-Substituted 3-Acylisoxazoles DOI

Piyaporn Arunkirirote,

Pornteera Suwalak,

Nattawadee Chaisan

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

A photochemical Machetti-De Sarlo reaction has been developed for preparing 5-substituted 3-acylisoxazoles from acylnitromethanes and terminal alkynes. This protocol utilizes an innovative electron donor-acceptor complex, generated

Language: Английский

Citations

Modular Synthesis of Divergent Thiofunctionalized Sulfoxonium Ylides DOI

Qiong Hu,

Mei-Zhu Bao,

Yuanjie Meng

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A metal-free protocol for the modular synthesis of diverse α-thiofunctionalized-α′-carbonyl sulfoxonium ylides from sulfoxonium–iodonium hybrid (I (III) /S (VI) -ylides) has been achieved.

Language: Английский

Citations

Isoxazole compounds: unveiling the synthetic strategy, In-silico SAR & Toxicity studies and future perspective as PARP inhibitor in cancer therapy DOI

Udita Malik,

Dilipkumar Pal

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116898 - 116898

Published: Sept. 24, 2024

Language: Английский

Citations