Green Chemistry, Год журнала: 2021, Номер 23(23), С. 9422 - 9427
Опубликована: Янв. 1, 2021
Electrochemical N -cyanation of secondary amines and α C tertiary have been established under transition metal-free conditions, which provide cyanamides nitriles with good functional group tolerance from simple systems.
Язык: Английский
Advanced Synthesis & Catalysis, Год журнала: 2020, Номер 362(9), С. 1724 - 1818
Опубликована: Янв. 20, 2020
Abstract Phosphorus‐substituted heterocycles represent an important class of organophosphorus compounds, which not only widely exist in biologically active pharmaceuticals, agrochemicals, but also have widespread applications material science and organic synthesis as ligands for transition metal complexes. The such compounds integrates the development new synthetic methods exploration efficient catalytic systems, reflects latest achievements organic, metal, photo even electrochemical catalysis, facilitates sufficient quantities related potential medicinal agents biological probes this area. Over past few decades, two major strategies been established toward phosphorus‐substituted heterocycles. This review summarizes recent progress field discusses reaction mechanisms detail. advantages limitations each subdivisional tactic are presented, opportunities still open outlined. magnified image
Язык: Английский
Процитировано
144
Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(7), С. 1810 - 1834
Опубликована: Фев. 16, 2021
Abstract Transition metal‐catalysed processes have been widely used for the functionalization of inert C−H bonds. Strategies benzylic position having a relatively weak bond (bond dissociation energy∼ 80–90 kcal/mol) differ from aliphatic and aromatic positions with stronger The recent advances in direct activation through generation C( sp 3 ) radicals demonstrated potential electrochemistry photochemistry as means constructing new chemical This review will cover progress organic radical strategies employing sustainable tools. In addition, mechanistic details typical reactions included which, turn, help researchers to look at this promising area different perspective towards discoveries often hidden opportunities. magnified image
Язык: Английский
Процитировано
111
Chemical Reviews, Год журнала: 2024, Номер 124(12), С. 7907 - 7975
Опубликована: Май 29, 2024
The increasing importance of azaheterocyclic phosphonates in the agrochemical, synthetic, and medicinal field has provoked an intense search development synthetic routes for obtaining novel members this family compounds. This updated review covers methodologies established since 2004, focusing on synthesis phosphonates, which phosphonate moiety is directly substituted onto to structure. Emphasizing recent advances, classifies newly developed approaches according ring size providing information biological activities whenever available. Furthermore, summarizes various methods formation C–P bonds, examining sustainable such as Michaelis–Arbuzov reaction, Michaelis–Becker Pudovik Hirao coupling, Kabachnik–Fields reaction. After analyzing applications investigated years, a predominant focus evaluation these compounds anticancer agents evident. emerging underline versatility potential compounds, highlighting need continued research expand interesting family.
Язык: Английский
Процитировано
14
Green Chemistry, Год журнала: 2020, Номер 22(18), С. 6170 - 6175
Опубликована: Янв. 1, 2020
Visible-light
induced
phosphonation
of
quinoxalines
and
quinoxalin-2(1
Язык: Английский
Процитировано
66
The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(17), С. 12378 - 12385
Опубликована: Авг. 16, 2021
Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for mild room temperature operation, environmental friendliness well broad substrate scope in both C–H bond donor source components.
Язык: Английский
Процитировано
55
The Chemical Record, Год журнала: 2020, Номер 20(12), С. 1530 - 1552
Опубликована: Окт. 5, 2020
Abstract Organophosphorus chemistry is a broad field with multi‐dimensional applications in research area of organic, biology, drug design and agrochemicals. Conventional methods have been adopted extensively to access phosphorylated compounds that rely on the use toxic, moisture sensitive phosphorylating agents occur presence oxidants, catalysts, as well high temperatures harsh conditions are required for complete transformations. However, recent progress has made phosphorylation reactions using electricity introduce green sustainable synthetic procedures. These can be performed at mild proceed excellent atom economy. Herein, we targeted electrochemical generation new bonds such C(sp 3 ) −P, 2 O−P, N−P, S−P Se−P. This review aimed offer an overview developments methodology easy organophosphorus electrochemistry.
Язык: Английский
Процитировано
47
Organic Letters, Год журнала: 2020, Номер 22(8), С. 3062 - 3066
Опубликована: Апрель 7, 2020
We report a direct and green electrochemical oxidative cross-dehydrogenative coupling reaction of N-heterocycles with hydrogen phosphoryl compounds under external oxidant-free conditions. Various phosphorylation products substituted carbazoles indoles are assembled in modest to excellent yields. A release process is preliminarily demonstrated H2 the sole byproduct. An imidazolium based ionic liquid selected as optimal electrolyte.
Язык: Английский
Процитировано
45
Green Chemistry, Год журнала: 2020, Номер 22(21), С. 7543 - 7551
Опубликована: Янв. 1, 2020
H2O serves as a safe oxygen source in the electrocatalytic oxidation of benzyl C–H, with significantly improved overpotential and faradaic efficiency on layered MnO2 catalysts.
Язык: Английский
Процитировано
45
Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(8), С. 4199 - 4207
Опубликована: Ноя. 12, 2020
Abstract Electrochemical organic synthesis has attracted increasing attentions as a sustainable and versatile synthetic platform. Quantitative assessment of the electro‐organic reactions, including reaction thermodynamics, electro‐kinetics, coupled chemical processes, can lead to effective analytical tool guide their future design. Herein, we demonstrate that electrochemical parameters such onset potential, Tafel slope, voltage be utilized electro‐descriptors for evaluation conditions prediction reactivities (yields). An “electro‐descriptor‐diagram” is generated, where reactive non‐reactive conditions/substances show distinct boundary. Successful predictions outcomes have been demonstrated using electro‐descriptor diagram, or from machine learning algorithms with experimentally‐derived electro‐descriptors. This method represents promising data‐acquisition, prediction, mechanistic investigation, high‐throughput screening general electro‐synthesis.
Язык: Английский
Процитировано
45
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(23)
Опубликована: Апрель 4, 2024
The present study reports an unprecedented protocol for the phosphonylation of unactivated C(sp
Язык: Английский
Процитировано
6