Applied Radiation and Isotopes, Год журнала: 2025, Номер 220, С. 111745 - 111745
Опубликована: Фев. 24, 2025
Язык: Английский
Medicinal Research Reviews, Год журнала: 2023, Номер 43(6), С. 2115 - 2176
Опубликована: Май 11, 2023
Abstract Breast cancer is the most malignant tumor in women, and there no absolute cure for it. Although treatment modalities including surgery, chemotherapy, radiotherapy are utilized breast cancer, it still a life‐threatening disease humans. Nanomedicine has provided new opportunity treatment, which focus of current study. The nanocarriers deliver chemotherapeutic agents natural products, both increase cytotoxicity against cells prevent development drug resistance. efficacy gene therapy boosted by nanoparticles delivery CRISPR/Cas9, Noncoding RNAs, RNAi, promoting their potential expression regulation. codelivery can exert synergistic impact on tumors enhance cellular uptake via endocytosis. Nanostructures able to induce photothermal photodynamic ablation cell death induction. provide microenvironment remodeling repolarization macrophages antitumor immunity. stimuli‐responsive nanocarriers, pH‐, redox‐, light‐sensitive, mediate targeted suppression tumors. Besides, diagnosis detect biomarkers. Various kinds have been employed therapy, carbon‐, lipid‐, polymeric‐ metal‐based nanostructures, different terms biocompatibility efficiency.
Язык: Английский
Процитировано
97
Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 255 - 255
Опубликована: Фев. 9, 2024
Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages therapeutic efficacy safety been the main target of interest. Its application immune system stability physiological environments cell membranes, low toxicity optimal bioperformances are critical to success engineered nanomaterials. unique optical properties great attractors. Recently, several physical chemical methods coating these NPs widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates biopolymers, among others, used coatings Au various applications, thus their biocompatibility while maintaining biological functions. This review mainly presents a general representative view different types NP functionalization using biomolecules, strategies mechanisms.
Язык: Английский
Процитировано
30
Cancer and Metastasis Reviews, Год журнала: 2024, Номер 43(1), С. 457 - 479
Опубликована: Янв. 16, 2024
Язык: Английский
Процитировано
27
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 15718 - 15729
Опубликована: Март 20, 2024
Surgical removal of tumor tissue remains the primary clinical approach for addressing breast cancer; however, complete excision is challenging, and remaining cells can lead to recurrence metastasis over time, which substantially deteriorates life quality patients. With aim improve local cancer radiotherapy, this work reports fabrication alginate (Alg) scaffolds containing bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing. Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA significantly increase formation reactive oxygen species, enhance inhibition cells, suppress their colony capacity. In addition, implanted under murine model show high therapeutic efficacy by reducing volume growth rate irradiation, while histological observation main organs reveals no cytotoxicity or side effects. 3D-printed produced with biocompatible biodegradable materials may potentially lower rates patients inhibiting residual following postsurgery as well exhibit anticancer properties other solid tumors.
Язык: Английский
Процитировано
18
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Фев. 22, 2024
Abstract Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture stratum corneum layer of skin lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, drug administration. offer limited invasiveness, ease application, minimal discomfort. Initially manufactured solely from metals, now available polymer‐based varieties. can be used create systems that deliver drugs chemicals uniformly, collect fluids, stimulus‐sensitive. Although these advancements favorable terms biocompatibility production costs, they insufficient for use MNs. This is first comprehensive review discusses individual MN toward evolution development smart multifunctional a variety novel impactful future applications. The study examines fabrication techniques, application purposes, experimental details constructs perform multiple concurrently, sensing, drug‐molecule release, sampling, remote communication capabilities. It highly likely near future, MN‐based will useful important component standard practice different
Язык: Английский
Процитировано
16
ACS Applied Bio Materials, Год журнала: 2023, Номер 6(6), С. 2266 - 2276
Опубликована: Июнь 5, 2023
Fruits are safe, toxin-free, and biomolecule-rich raw materials that may be utilized to decrease metal ions stabilize nanoparticles. Here, we demonstrate the green synthesis of magnetite nanoparticles which were first capped with a layer silica, followed by decoration silver nanoparticles, termed Ag@SiO2@Fe3O4, using lemon fruit extract as reducing agent in size range ∼90 nm. The effect stabilizer on characteristics was examined via different spectroscopy techniques, elemental composition multilayer-coated structures verified. saturation magnetization bare Fe3O4 at room temperature recorded 78.5 emu/g, whereas it decreased 56.4 43.8 emu/g for silica coating subsequent All displayed superparamagnetic behavior almost zero coercivity. While further processes, specific surface area increased from 67 180 m2 g–1 after addition reached 98 g–1, can explained organization an island-like model. Zeta potential values also −18 −34 mV coating, indicating enhanced stabilization silver. antibacterial tests against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) revealed SiO2@Fe3O4 did not show sufficient effect, while even low concentrations (≤ 200 μg/mL), high activity due existence atoms Furthermore, vitro cytotoxicity assay Ag@SiO2@Fe3O4 toxic HSF-1184 cells μg/mL concentration. Antibacterial during consecutive magnetic separation recycling steps investigated, offered more than 10 cycles recycling, making them potentially useful biomedical fields.
Язык: Английский
Процитировано
25
Environmental Research, Год журнала: 2023, Номер 225, С. 115673 - 115673
Опубликована: Март 10, 2023
Язык: Английский
Процитировано
23
Nanoscale Advances, Год журнала: 2024, Номер 6(11), С. 2766 - 2812
Опубликована: Янв. 1, 2024
From HAuCl 4 , nano-gold is synthesized via physical, chemical and green techniques. Systematic engineering with different functionalities shapes into a sword multimodal applicability against breast cancer, but what are the consequences?
Язык: Английский
Процитировано
12
Pathology - Research and Practice, Год журнала: 2024, Номер 264, С. 155706 - 155706
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
8
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 333, С. 125903 - 125903
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
1