Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1571 - 1571
Опубликована: Дек. 9, 2024
Microneedles
(MNs),
composed
of
multiple
micron-scale
needle-like
structures
attached
to
a
base,
offer
minimally
invasive
approach
for
transdermal
drug
delivery
by
penetrating
the
stratum
corneum
and
delivering
therapeutic
agents
directly
epidermis
or
dermis.
Hydrogel
microneedles
(HMNs)
stand
out
among
various
MN
types
due
their
excellent
biocompatibility,
high
drug-loading
capacity,
tunable
drug-release
properties.
This
review
systematically
examines
matrix
materials
fabrication
methods
HMN
systems,
highlighting
advancements
in
natural
synthetic
polymers,
explores
applications
treating
conditions
such
as
wound
healing,
hair
loss,
cardiovascular
diseases,
cancer.
Furthermore,
potential
HMNs
disease
diagnostics
is
discussed.
The
identifies
key
challenges,
including
limited
mechanical
strength,
efficiency,
lack
standardization,
while
proposing
strategies
overcome
these
issues.
With
integration
intelligent
design
enhanced
control
over
dosage
safety,
are
poised
revolutionize
expand
personalized
medicine.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 6, 2025
Abstract
The
use
of
microneedles
(MNs)
has
been
established
as
an
effective
transdermal
drug
delivery
strategy
that
extensively
deployed
for
treating
various
diseases,
including
skin
diseases.
MNs
can
surpass
the
constraints
conventional
methods
by
their
superior
safety
and
efficacy
through
precise
targeting,
while
simultaneously
enabling
painless
delivery.
Currently,
are
increasingly
used
carriers
delivery,
with
loading
insoluble
drugs
to
improve
treatment
efficiency
or
combining
bioactive
substances
construction
efficient
system
maximize
effects
substances.
preparation
diverse,
them
meet
requirements
most
applications.
emergence
addressed
shortcomings
associated
drugs,
expanded
applications
substances,
improved
in
clinical
practice.
This
review
summarizes
current
information
on
application
a
variety
such
psoriasis,
vitiligo,
alopecia,
hypertrophic
scarring,
atopic
dermatitis,
melanoma,
acne,
infections.
future
opportunities
diseases
also
discussed.
Despite
substantial
progress
vectors,
issues
low
poor
mechanical
strength
during
remain
main
challenges.
Therefore,
implementation
MNs-based
therapies
remains
limited,
highlighting
key
research.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 375 - 375
Опубликована: Март 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
Abstract
Nonviral
vectors,
such
as
liposomes,
offer
potential
for
targeted
gene
delivery
in
cancer
therapy.
Liposomes,
composed
of
phospholipid
vesicles,
have
demonstrated
efficacy
nanocarriers
genetic
tools,
addressing
the
limitations
off‐targeting
and
degradation
commonly
associated
with
traditional
therapy
approaches.
Due
to
their
biocompatibility,
stability,
tunable
physicochemical
properties,
they
overcoming
challenges
therapy,
low
transfection
efficiency
poor
stability
biological
fluids.
Despite
these
advancements,
there
remains
a
gap
understanding
optimal
utilization
nanoliposomes
enhanced
treatment.
This
review
delves
into
present
state
carriers
tools
sheds
light
on
safeguard
payloads
facilitate
cell
internalization
alongside
evolution
smart
delivery.
The
linked
biocompatibility
factors
that
restrict
effectiveness
are
also
discussed
along
exploring
strategies
by
analyzing
recent
advancements
offering
future
directions.
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(12)
Опубликована: Дек. 1, 2024
ABSTRACT
This
review
aims
to
provide
a
comprehensive
analysis
of
recent
advancements
in
smart
microneedles
(MNs)
within
the
biomedical
field,
focusing
on
integration
stimuli‐responsive
polymers
for
enhanced
therapeutic
and
diagnostic
applications.
Conventional
drug
delivery
methods
are
known
face
limitations
precision,
safety,
patient
compliance,
which
can
be
addressed
by
innovative
features
MNs.
Through
use
various
polymers,
these
MNs
have
been
designed
react
environmental
or
physiological
cues,
allowing
on‐demand
release,
biomarker
sensing,
localized
interventions.
Fundamental
materials
used
fabrication
MNs,
including
metals,
composite
hydrogels,
reviewed,
different
categories
stimuli‐responsiveness,
such
as
photo,
electro,
thermal,
mechanical,
biochemical,
explored.
Application‐specific
designs
areas
delivery,
cancer
therapy,
diabetes
management,
skin
disease
treatments
also
examined.
this
discussion,
it
is
highlighted
that
poised
play
significant
role
advancing
personalized
noninvasive
medical
treatments.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2637 - 2659
Опубликована: Апрель 30, 2024
Extensive
research
has
been
conducted
on
the
application
of
nanoparticles
in
treatment
cancer
and
infectious
diseases.
Due
to
their
exceptional
characteristics
flexible
structure,
they
are
classified
as
highly
efficient
drug
delivery
systems,
ensuring
both
safety
targeted
delivery.
Nevertheless,
still
encounter
obstacles,
such
biological
instability,
absence
selectivity,
recognition
unfamiliar
elements,
quick
elimination,
which
restrict
remedial
capacity.
To
surmount
these
drawbacks,
biomimetic
nanotechnology
developed
that
utilizes
T
cell
natural
killer
(NK)
membrane-encased
sophisticated
methods
administering
drugs.
These
can
extend
duration
circulation
avoid
immune
system
clearance.
During
membrane
extraction
coating
procedure,
surface
proteins
immunological
cells
transferred
nanoparticles.
Such
present
confer
several
benefits
nanoparticles,
including
prolonged
circulation,
enhanced
targeting,
controlled
release,
specific
cellular
contact,
reduced
vivo
toxicity.
This
review
focuses
nanosystems
derived
from
membranes
NK
comprehensive
manufacture,
applications
viral
infections.
Furthermore,
potential
applications,
prospects,
existing
challenges
medical
implementation
highlighted.
RSC Advances,
Год журнала:
2024,
Номер
14(37), С. 26723 - 26737
Опубликована: Янв. 1, 2024
Antimicrobial
wound
dressings
offer
enhanced
efficacy
compared
to
conventional
dressing
platforms
by
limiting
bacterial
infections,
expediting
the
healing
process,
and
creating
a
barrier
against
additional
contamination.
