Pathology - Research and Practice, Год журнала: 2024, Номер 266, С. 155747 - 155747
Опубликована: Ноя. 28, 2024
Язык: Английский
Cancers, Год журнала: 2025, Номер 17(6), С. 940 - 940
Опубликована: Март 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Язык: Английский
Процитировано
2
Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102177 - 102177
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155950 - 155950
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Extracellular vesicles are nanoscale released by a diversity of cells that mediate intercellular communication transporting an array biomolecules. They gaining increasing attention in cancer research due to their ability carry specific biomarkers. This characteristic makes them potentially useful for highly sensitive, noninvasive diagnostic procedures and more precise prognostic assessments. Consequently, EVs emerging as transformative tool treatment, facilitating early detection personalized medicine. Despite significant progress, clinical implementation is hindered challenges EV isolation, purification, characterization. However, developing advanced biosensor technologies offers promising solutions these obstacles. review highlights recent progress biosensors analysis, focusing on various sensing modalities including optical, electrochemical, microfluidic, nanomechanical, biological sensors. We also explore techniques characterization, such electron microscopy, atomic force nanoparticle tracking single-particle analysis. Furthermore, the critically assesses associated with put forward future directions, aiming usher cutting-edge era precision medicine through advanced, sensor-based, diagnosis detecting EV-carried
Язык: Английский
Процитировано
0
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104774 - 104774
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Sustainable Food Technology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Fruit exosomes are the source of natural cancer therapeutic tools.
Язык: Английский
Процитировано
2