Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Biomaterials, Год журнала: 2021, Номер 277, С. 121110 - 121110

Опубликована: Авг. 30, 2021

Язык: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Год журнала: 2021, Номер 121(4), С. 1981 - 2019

Опубликована: Янв. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Язык: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100946 - 100946

Опубликована: Авг. 13, 2020

Язык: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Год журнала: 2021, Номер 18(6)

Опубликована: Ноя. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Язык: Английский

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The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Год журнала: 2021, Номер 50(8), С. 5086 - 5125

Опубликована: Янв. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Язык: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Язык: Английский

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Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Advanced Functional Materials, Год журнала: 2021, Номер 31(22)

Опубликована: Март 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Язык: Английский

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An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy

Advanced Materials, Год журнала: 2022, Номер 34(43)

Опубликована: Сен. 2, 2022

Abstract Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers great opportunities for exploring the use copper‐based nanomaterials inducing cuproptosis cancer treatment. Here, glucose oxidase (GOx)‐engineered nonporous copper(I) 1,2,4‐triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], starvation‐augmented and photodynamic synergistic therapy developed. Importantly, catalytic activity GOx shielded in scaffold but can be “turned on” efficient depletion only upon glutathione (GSH) stimulation cells, thereby proceeding starvation therapy. The GSH sensitizes cells to GOx@[Cu(tz)]‐mediated cuproptosis, producing aggregation lipoylated mitochondrial proteins, target copper‐induced toxicity. increased intracellular hydrogen peroxide (H 2 O ) levels, due oxidation glucose, activates type I (PDT) efficacy GOx@[Cu(tz)]. vivo experimental results indicate GOx@[Cu(tz)] produces negligible systemic toxicity inhibits tumor growth by 92.4% athymic mice bearing 5637 bladder tumors. This thought first report cupreous nanomaterial capable cuproptosis‐based cancer, which should invigorate studies pursuing rational design efficacious strategies based on cuproptosis.

Язык: Английский

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Recent advances in enhanced chemodynamic therapy strategies

Nano Today, Год журнала: 2021, Номер 39, С. 101162 - 101162

Опубликована: Май 18, 2021

Язык: Английский

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Copper-Induced Tumor Cell Death Mechanisms and Antitumor Theragnostic Applications of Copper Complexes

Nanomedicine, Год журнала: 2022, Номер 17(5), С. 303 - 324

Опубликована: Янв. 21, 2022

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing irreversible damage. Copper can induce multiple forms of cell death, including apoptosis and autophagy, through various mechanisms, reactive oxygen species accumulation, proteasome inhibition, antiangiogenesis. Hence, in vivo has attracted tremendous attention is the research spotlight field treatment. This review first highlights three typical copper's antitumor mechanisms. Then, development diverse biomaterials nanotechnology allowing to be fabricated into structures realize its theragnostic action discussed. Novel complexes their clinical applications are subsequently described.

Язык: Английский

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