ACS Nano,
Год журнала:
2022,
Номер
16(12), С. 20400 - 20418
Опубликована: Ноя. 28, 2022
Immune
checkpoint
blockade
(ICB)
therapy
has
attracted
widespread
attention
in
cancer
treatment.
Due
to
the
low
immunogenicity
and
immune
suppression
state
tumor
microenvironment
(TME),
therapeutic
effects
are
only
moderate.
Herein,
a
TME-activable
manganese-boosted
catalytic
immunotherapy
is
designed
for
synergism
with
ICB
kill
tumors
efficiently.
The
cell
membrane
(CM)-wrapping
multienzyme-mimic
manganese
oxide
(MnOx)
nanozyme
termed
CM@Mn
showed
intrinsic
peroxidase
oxidase-like
activities
an
acidic
TME.
These
can
generate
toxic
hydroxyl
(•OH)
superoxide
radicals
(•O2-)
killing
evoking
immunogenic
death
(ICD).
Furthermore,
TME-responsive
release
of
Mn2+
directly
promotes
dendritic
maturation
macrophage
M1
repolarization,
resulting
reversal
immunosuppressive
TME
into
immune-activating
environment.
Additionally,
hypoxia
relief
caused
by
catalase-like
activity
also
contributes
process
reversal.
Finally,
robust
tumor-specific
T
cell-mediated
antitumor
response
occurs
support
PD-1
blockade.
proliferation
primary
metastatic
was
inhibited,
long-term
memory
effect
induced.
strategy
outlined
here
may
serve
as
promising
candidate
tumor-integrated
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Advanced Materials,
Год журнала:
2021,
Номер
33(48)
Опубликована: Сен. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
Bioactive Materials,
Год журнала:
2021,
Номер
6(12), С. 4389 - 4401
Опубликована: Апрель 30, 2021
Nanozymes
have
become
a
new
generation
of
antibiotics
with
exciting
broad-spectrum
antibacterial
properties
and
negligible
biological
toxicity.
However,
their
inherent
low
catalytic
activity
limits
properties.
Herein,
Cu
single-atom
sites/N
doped
porous
carbon
(Cu
SASs/NPC)
is
successfully
constructed
for
photothermal-catalytic
treatment
by
pyrolysis-etching-adsorption-pyrolysis
(PEAP)
strategy.
SASs/NPC
stronger
peroxidase-like
activity,
glutathione
(GSH)-depleting
function,
photothermal
property
compared
non-Cu-doped
NPC,
indicating
that
doping
significantly
improves
the
performance
nanozymes.
can
effectively
induce
in
presence
H
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(12), С. 4996 - 5041
Опубликована: Янв. 1, 2022
This
review
systematically
summarizes
the
research
status,
challenges,
prospects,
and
potential
bench-to-bedside
translation
of
minimally
invasive
nanomedicines.
Advanced Materials,
Год журнала:
2021,
Номер
34(7)
Опубликована: Дек. 5, 2021
Clinical
applications
of
nanozyme-initiated
chemodynamic
therapy
(NCDT)
have
been
severely
limited
by
the
poor
catalytic
efficiency
nanozymes,
insufficient
endogenous
hydrogen
peroxide
(H2
O2
)
content,
and
its
off-target
consumption.
Herein,
authors
developed
a
hollow
mesoporous
Mn/Zr-co-doped
CeO2
tandem
nanozyme
(PHMZCO-AT)
with
regulated
multi-enzymatic
activities,
that
is,
enhancement
superoxide
dismutase
(SOD)-like
peroxidase
(POD)-like
activities
inhibition
catalase
(CAT)-like
activity.
PHMZCO-AT
as
H2
homeostasis
disruptor
promotes
evolution
restrains
elimination
to
achieve
intensive
NCDT.
SOD-like
activity
catalyzes
anion
(O2•-
into
in
tumor
region.
The
suppression
CAT
depletion
glutathione
largely
weaken
decomposition
O.
Elevated
is
then
catalyzed
downstream
POD-like
generate
toxic
hydroxyl
radicals,
further
inducing
apoptosis
death.
T1
-weighted
magnetic
resonance
imaging
X-ray
computed
tomography
are
also
achieved
using
due
existence
paramagnetic
Mn2+
high
attenuation
ability
elemental
Zr,
permitting
vivo
tracking
therapeutic
process.
This
work
presents
typical
paradigm
NCDT
efficacy
regulating
nanozymes
perturb
homeostasis.
Chemical Science,
Год журнала:
2021,
Номер
13(4), С. 863 - 889
Опубликована: Ноя. 29, 2021
Applying
Fenton
chemistry
in
the
tumor
microenvironment
(TME)
for
cancer
therapy
is
most
significant
feature
of
chemodynamic
(CDT).
Owing
to
mild
acid
and
overexpressed
H2O2
TME,
more
cytotoxic
hydroxyl
radicals
(˙OH)
are
generated
cells
via
Fenton-like
reactions.
Without
external
stimulus
drug
resistance
generation,
reactive
oxygen
species
(ROS)-mediated
CDT
exhibits
a
specific
desirable
anticancer
effect
has
been
seen
as
promising
strategy
therapy.
However,
optimizing
treatment
efficiency
TME
still
challenging
because
limited
catalytic
agents
strong
antioxidant
capacity
TME.
Hence,
scientists
trying
their
best
design
fabricate
many
with
excellent
activity
remodeling
optimal
CDT.
In
this
perspective,
latest
progress
discussed,
some
representative
examples
presented.
Consequently,
strategies
further
guided
by
provided.
Most
importantly,
several
feasible
ways
developing
future
offered
reference.
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
