Integrating Antioxidant Functionality into Polymer Materials: Fundamentals, Strategies, and Applications

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(35), С. 41372 - 41395

Опубликована: Авг. 27, 2021

While antioxidants are widely known as natural components of healthy food and drinks or additives to commercial polymer materials prevent their degradation, recent years have seen increasing interest in enhancing the antioxidant functionality newly developed coatings. This paper provides a critical overview comparative analysis multiple ways integrating within diverse materials, including bulk films, electrospun fibers, self-assembled Polyphenolic moieties with varied molecular architecture focus this Review, because abundance, nontoxic nature, potent activity. Polymer integrated polyphenolic offer opportunities challenges that span from fundamentals applications. In addition traditional blending developments surface grafting assembly via noncovalent interaction for controlling localization versus migration molecules discussed. The versatile chemistry offers numerous possibilities programmed inclusion these using not only van der Waals interactions covalent tethering polymers, but also hydrogen-bonding neutral molecules. An understanding rational use polyphenol surrounding can enable precise control concentration retention delivery rate packaging, biomedical, environmental

Язык: Английский

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Antifouling polymers for nanomedicine and surfaces: recent advances

Nanoscale, Год журнала: 2023, Номер 15(38), С. 15472 - 15512

Опубликована: Янв. 1, 2023

Hydrophilic antifouling polymers are important materials for nanomedicine and surface modification applications. In this review, we discuss their structures, properties, function in the context of recent nanoscale

Язык: Английский

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Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polymers, Год журнала: 2022, Номер 14(3), С. 479 - 479

Опубликована: Янв. 25, 2022

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, exploitation of PEMUCs in field requires a deep understanding most fundamental bases underlying their assembly processes, and control properties to fabricate novel materials with optimized ability specific targeting therapeutic capacity. This review presents an updated perspective on multiple avenues opened application field, aiming highlight some important advantages offered by LbL fabrication platforms use detection treatment diseases.

Язык: Английский

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Exploiting the layer-by-layer nanoarchitectonics for the fabrication of polymer capsules: A toolbox to provide multifunctional properties to target complex pathologies

Advances in Colloid and Interface Science, Год журнала: 2022, Номер 304, С. 102680 - 102680

Опубликована: Апрель 17, 2022

Polymer capsules fabricated via the layer-by-layer (LbL) approach have attracted a great deal of attention for biomedical applications thanks to their tunable architecture. Compared alternative methods, in which precise control over final properties systems is usually limited, intrinsic versatility LbL allows functionalization all constituents polymeric following relatively simple protocols. In fact, can be adjusted from inner cavity outer layer through shell, resulting therapeutic, diagnostic, or theranostic (i.e., combination therapeutic and diagnostic) agents that adapted particular characteristics patient face challenges encountered complex pathologies. The industry demands novel biomaterials capable targeting several mechanisms and/or cellular pathways simultaneously while being tracked by minimally invasive techniques, thus highlighting need shift monofunctional multifunctional polymer capsules. present review, those strategies permit advanced are accordingly introduced. Each capsule cavity, multilayer membrane layer) thoroughly analyzed overview toward fabrication presented. Special emphasis given potential these capsules, including examples performed vitro vivo validation studies. Finally, process future perspective safe translation into clinic summarized.

Язык: Английский

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Calcium Carbonate Core–Shell Particles for Incorporation of ²²⁵Ac and Their Application in Local α-Radionuclide Therapy

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(22), С. 25599 - 25610

Опубликована: Май 24, 2021

Actinium-225 (225Ac) radiolabeled submicrometric core-shell particles (SPs) made of calcium carbonate (CaCO3) coated with biocompatible polymers [tannic acid-human serum albumin (TA/HSA)] have been developed to improve the efficiency local α-radionuclide therapy in melanoma models (B16-F10 tumor-bearing mice). The 225Ac-SPs possess radiochemical stability and demonstrate effective retention 225Ac its daughter isotopes. SPs additionally labeled zirconium-89 (89Zr) perform biodistribution studies using positron emission tomography-computerized tomography (PET/CT) imaging for 14 days after intratumoral injection. According PET/CT analysis, a significant accumulation 89Zr-SPs tumor area is revealed whole investigation period, which correlates direct radiometry analysis administration 225Ac-SPs. histological has no abnormal changes healthy tissue organs treatment (e.g., acute pathologic findings are detected liver kidneys). At same time, inhibition growth observed as compared control samples [nonradiolabeled phosphate-buffered saline (PBS)]. mice resulted prolonged survival samples. Thus, our study validates application 225Ac-doped submicron CaCO3 therapy.

Язык: Английский

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Enhanced antitumor immune responses via a new agent [131I]-labeled dual-target immunosuppressant

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2022, Номер 50(2), С. 275 - 286

Опубликована: Окт. 15, 2022

Radionuclides theranostic are ideal "partners" for bispecific antibodies to explore the immune response of patients and synergistic treatment. A single-domain antibody-Fc fusion protein, KN046, exhibits a good treatment effect by binding programmed cell death-ligand 1 (PD-L1) cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). An ionizing-radiation stimulus mediated low-dose [131I] may be used immunopotentiation. In this study, we established [131I]-labeled KN046 as novel radioimmunotherapy agent treat malignant melanoma explored mechanism.After intravenous injection [131I]-KN046, SPECT/CT imaging was applied identify candidate targets immunotherapy. [18F]-FDG [68 Ga]-NOTA-GZP (granzyme B-specific PET agent) micro-PET/CT assess in vivo after [131I]-KN046 The evaluated exploring [131I]-based radionuclide-induced release tumor immunogenicity-related antigens well histology survival tumor-bearing mice treatment.The constructed exhibited high affinity specificity PD-L1/CTLA-4 had excellent intratumoral retention capability so achieve antitumor efficacy. More importantly, combination KN046-enhanced immunosensitivity increased immunotherapy rates significantly. Exposure cells led upregulated expression MHC-I Fas surface molecules significant increases degree T-cell activation counts tumor-infiltrating immunocytes.Use combined with dual-target immunosuppressant could exploited subset responders but also great potential enhancing responses.

Язык: Английский

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Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Nanomaterials, Год журнала: 2021, Номер 11(10), С. 2502 - 2502

Опубликована: Сен. 26, 2021

One of the undeniable trends in modern bioengineering and nanotechnology is use various biomolecules, primarily a polymeric nature, for design formulation novel functional materials controlled targeted drug delivery, bioimaging theranostics, tissue engineering, other bioapplications. Biocompatibility, biodegradability, possibility replicating natural cellular microenvironments, minimal toxicity typical biogenic polymers are features that have secured growing interest them as building blocks biomaterials fourth generation. Many recent studies showed promise hard-templating approach fabrication nano- microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules beads, critically assessing progress made this field research, outlining current challenges perspectives architectures. According to classification templates, sequentially considers biopolymer structures templated non-porous particles, porous crystal drugs. Opportunities functionalization tailor toward specific bioapplications highlighted separate section.

Язык: Английский

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A novel magnetically guided, oxygen propelled CoPt/Au nanosheet motor in conjugation with a multilayer hollow microcapsule for effective drug delivery and light triggered drug release

Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(1), С. 176 - 186

Опубликована: Ноя. 27, 2023

In recent years, nanomotors have been developed and attracted extensive attention in biomedical applications.

Язык: Английский

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Development of 64Cu-DOX/DOX-loaded chitosan-BSA multilayered hollow microcapsules for selective lung drug delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 73, С. 103477 - 103477

Опубликована: Июнь 3, 2022

Язык: Английский

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Direct Radiolabeling of Trastuzumab-Targeting Triblock Copolymer Vesicles with ⁸⁹Zr for Positron Emission Tomography Imaging

Biomacromolecules, Год журнала: 2023, Номер 24(4), С. 1784 - 1797

Опубликована: Март 16, 2023

Radiolabeled drug nanocarriers that can be easily imaged via positron emission tomography (PET) are highly significant as their in vivo outcome quantitatively PET-traced with high sensitivity. However, typical radiolabeling of most PET-guided theranostic vehicles utilizes modification chelator ligands, which presents various challenges. In addition, unlike passive tumor targeting, specific targeting delivery binding affinity to overexpressed cancer cell receptors is crucial improve the tumors. Herein, we developed 89Zr-labeled triblock copolymer polymersomes 60 nm size through chelator-free radiolabeling. The assembled from poly(N-vinylpyrrolidone)5-b-poly(dimethylsiloxane)30-b-poly(N-vinylpyrrolidone)5 (PVPON5-PDMS30-PVPON5) copolymers followed by adsorption a degradable tannin, tannic acid (TA), on polymersome surface hydrogen bonding. TA serves an anchoring layer for both 89Zr radionuclide and recombinant humanized monoclonal antibody, trastuzumab (Tmab). Unlike bare PVPON5-PDMS30-PVPON5 polymersomes, TA- Tmab-modified demonstrated radiochemical yield more than 95%. Excellent retention vesicle membrane up 7 days was confirmed PET imaging. Animal biodistribution using healthy BALB/c mice clearance spleen liver without accumulation bone, free nonbound radiotracer. 89Zr-radiolabeled were found specifically target BT474 HER2-positive breast cells Tmab-TA complex surface. noncovalent Tmab advantageous nanoparticle compared currently covalent methods, it allows easy quick integration broad range proteins. Given ability these encapsulate release anticancer therapeutics, they further expanded precision-targeted therapeutic carriers advancing human health effective strategies.

Язык: Английский

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