Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Chemical Society Reviews, Год журнала: 2022, Номер 51(23), С. 9759 - 9830

Опубликована: Янв. 1, 2022

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.

Язык: Английский

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Adsorption of water and formic acid molecules on the (104) surface of calcite: a theoretical study by DFT-D3

New Journal of Chemistry, Год журнала: 2023, Номер 47(18), С. 8737 - 8743

Опубликована: Янв. 1, 2023

The adsorption preferences of water and formic acid on different surfaces calcite were systematically studied with density functional theory simulations.

Язык: Английский

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Development of Nanocarrier-Based Radionuclide and Photothermal Therapy in Combination with Chemotherapy in Melanoma Cancer Treatment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(10), С. 13460 - 13471

Опубликована: Март 3, 2023

Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy. synthesized effectively labeled 188Re radionuclide radiolabeling efficiency (94-98%) radiochemical stability (>95%) appropriate for Further, 188Re-Au NRs, mediating conversion laser radiation into heat, were intratumorally injected PTT was applied. Upon irradiation near-infrared laser, dual achieved. Additionally, 188Re-labeled NRs paclitaxel (PTX) has improved (188Re-labeled irradiation, PTX) monoregime. Thus, this local triple-combination step toward clinical translation use treatment.

Язык: Английский

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Design and one-pot synthesis of new substituted pyrrolo[1,2-a]thieno[3,2-e]pyrimidine as potential antitumor agents: In vitro and in vivo studies

Bioorganic Chemistry, Год журнала: 2024, Номер 148, С. 107468 - 107468

Опубликована: Май 16, 2024

Язык: Английский

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Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer

Journal of Controlled Release, Год журнала: 2022, Номер 344, С. 1 - 11

Опубликована: Фев. 16, 2022

Язык: Английский

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A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

Chemical Communications, Год журнала: 2022, Номер 59(7), С. 807 - 835

Опубликована: Ноя. 11, 2022

Transferring the layer-by-layer (LbL) coating approach from planar surfaces to spherical templates and subsequently dissolving these leads fabrication of polyelectrolyte multilayer capsules. The versatility coatings capsules their flexibility upon bringing in virtually any material into has quickly drawn substantial attention. Here, we provide an overview main developments this field, highlighting trends last decade. In beginning, various methods encapsulation release are discussed followed by a broad range applications, which were developed explored. We also outline current trends, where applications is continuing grow, including addition whole new different application areas.

Язык: Английский

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Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polymers, Год журнала: 2022, Номер 14(3), С. 479 - 479

Опубликована: Янв. 25, 2022

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, exploitation of PEMUCs in field requires a deep understanding most fundamental bases underlying their assembly processes, and control properties to fabricate novel materials with optimized ability specific targeting therapeutic capacity. This review presents an updated perspective on multiple avenues opened application field, aiming highlight some important advantages offered by LbL fabrication platforms use detection treatment diseases.

Язык: Английский

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Calcium carbonate nanoparticles tumor delivery for combined chemo-photodynamic therapy: Comparison of local and systemic administration

Journal of Controlled Release, Год журнала: 2023, Номер 359, С. 400 - 414

Опубликована: Июнь 16, 2023

Язык: Английский

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Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors

Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер 59, С. 102753 - 102753

Опубликована: Май 9, 2024

Язык: Английский

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Universal Chelator-Free Radiolabeling of Organic and Inorganic-Based Nanocarriers with Diagnostic and Therapeutic Isotopes for Internal Radiotherapy

Chemistry of Materials, Год журнала: 2022, Номер 34(14), С. 6593 - 6605

Опубликована: Июль 8, 2022

Biomedical application of various nanoparticles (NPs) for bioimaging and therapeutic purposes attracts huge interest. In particular, NPs can be used as nanocarriers radionuclides radiotherapy malignant neoplasms. However, most approaches NP radiolabeling are complicated, their transfer into clinical practice is difficult due to multistep process, limited reproducibility, lack an automated procedure. Here, we develop a universal method suitable (either organic or inorganic) internal B16-F10 melanoma tumors. The obtained (polylactide, silica, gold, iron oxide) were labeled with diagnostic (99mTc) (188Re) high efficiency (∼94–98%) radiochemical stability (>95%). After intratumoral administration, these 188Re-labeled mostly remained in the tumor, inhibiting tumor growth rate compared untreated absence any significant leakage radiolabeled healthy tissues (the liver, heart, kidneys, lungs, spleen) was confirmed by single-photon emission computed tomography (SPECT) direct radiometry analysis. Histological analysis revealed no abnormal changes organs after therapy (e.g., acute pathologic findings detected liver kidneys). As result, treatment mice led prolonged survival control group. Thus, our study provides general guidance use different types radionuclide therapy.

Язык: Английский

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