Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Nano Select, Год журнала: 2021, Номер 3(4), С. 792 - 828

Опубликована: Окт. 13, 2021

Abstract Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due their unique characteristics such as tunable surface properties well plasmon resonance (SPR), GNPs garnered attention exclusively therapy and diagnostics. Their ease of synthesis compatibility with functionalizing ligands has made them efficient a robust platform. flexibility functionalization, profoundly cancer treatment as, antiviral, antibacterial agents. In addition, owing possessing optical properties, utilized molecular imaging contrast agent. This article discusses highlights special that exploited recent years improve research field nuclear medicine, agent, vaccine development, medical implant, diagnostics, biosensing, lab‐on‐chip Moreover, size dependent biocompatibility, biodistribution, excreation was discussed details for vivo At the forefront modern theraputic technology, based antiviral agents great potential which is also highlighted briefly this article. current state ongoing clinical trials challenges associated regulatory approval are explored. Lastly, sheds light on findings toxicity prospects future direct research.

Язык: Английский

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Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Journal of Analysis and Testing, Год журнала: 2022, Номер 6(3), С. 247 - 273

Опубликована: Янв. 13, 2022

Язык: Английский

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Recent advances on paper-based microfluidic devices for bioanalysis

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 158, С. 116893 - 116893

Опубликована: Дек. 23, 2022

Язык: Английский

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Colorimetric sensing for translational applications: from colorants to mechanisms

Chemical Society Reviews, Год журнала: 2024, Номер 53(15), С. 7681 - 7741

Опубликована: Янв. 1, 2024

This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.

Язык: Английский

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A Smartphone Optical Device for Point-of-Care Testing of Glucose and Cholesterol Using Ag NPs/UiO-66-NH₂-Based Ratiometric Fluorescent Probe

Analytical Chemistry, Год журнала: 2021, Номер 93(48), С. 16240 - 16247

Опубликована: Ноя. 23, 2021

Point-of-care testing (POCT) with the advantages of simplicity, rapidity, portability, and low-cost is great importance to improve healthcare, especially in resource-limited settings home healthcare settings. Moreover, it a challenge quantitative POCT multiplexed biomarkers within single accessible assay but provides enhanced diagnostic accuracy improved efficiency. Herein, smartphone optical device has been designed for glucose cholesterol metabolic syndrome patients using ratiometric fluorescent sensor. The sensing system Ag NPs/UiO-66-NH2 o-phenylenediamine presents dual-emission response H2O2 (the main product catalyzed by oxidase oxidase) on account inner filter effect, resulting an increase fluorescence intensity ratio (F555 nm/F425 nm) accompanied distinguishable color transition from blue yellow green. After compositing probes flexible substrate, obtained test strip can be integrated smartphone-based portable platform read RGB values accurate both detection limits 10 μmol L-1, which are hundreds times lower than their concentrations human serum. With low-cost, ease operation, broad adaptability, this holds potential numerous targets personalized clinical diagnosis.

Язык: Английский

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Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring

Theranostics, Год журнала: 2022, Номер 12(14), С. 6308 - 6338

Опубликована: Янв. 1, 2022

Diabetes mellitus accompanies an abnormally high glucose level in the bloodstream.Early diagnosis and proper glycemic management of blood are essential to prevent further progression complications.Biosensor-based colorimetric detection has progressed shown potential portable inexpensive daily assessment levels because its simplicity, low-cost, convenient operation without sophisticated instrumentation.Colorimetric biosensors commonly use natural enzymes that recognize chromophores detect enzymatic reaction products.However, many have inherent defects, limiting their extensive application.Recently, nanozyme-based drawn attention due merits including sensitivity, stability under strict conditions, flexible structural design with low-cost materials, adjustable catalytic activities.This review discusses various nanozyme analytic methods mechanisms, recent machine learning based methods, quantification systems, applications future directions for monitoring managing diabetes.

Язык: Английский

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Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 157, С. 116806 - 116806

Опубликована: Окт. 29, 2022

Язык: Английский

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Nanomaterial-based microfluidic systems for cancer biomarker detection: Recent applications and future perspectives

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 158, С. 116835 - 116835

Опубликована: Ноя. 18, 2022

Язык: Английский

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Nanomaterials‐assisted metabolic analysis toward in vitro diagnostics

Exploration, Год журнала: 2022, Номер 2(3)

Опубликована: Апрель 16, 2022

In vitro diagnostics (IVD) has played an indispensable role in healthcare system by providing necessary information to indicate disease condition and guide therapeutic decision. Metabolic analysis can be the primary choice facilitate IVD since it characterizes downstream metabolites offers real-time feedback of human body. Nanomaterials with well-designed composition nanostructure have been developed for construction high-performance detection platforms toward metabolic analysis. Herein, we summarize recent progress nanomaterials-assisted related applications IVD. We first introduce important that nanomaterials play when coupled different platforms, including electrochemical sensors, optical spectrometry, mass spectrometry. further highlight applications, from perspectives both targeted biomarker quantitation untargeted fingerprint extraction. This review provides fundamental insights into function analysis, thus facilitating design next-generation diagnostic devices clinical practice.

Язык: Английский

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Plasmonic nanosensors for point-of-care biomarker detection

Materials Today Bio, Год журнала: 2022, Номер 14, С. 100263 - 100263

Опубликована: Март 1, 2022

Advancement of materials along with their fascinating properties play increasingly important role in facilitating the rapid progress medicine. An excellent example is recent development biosensors based on nanomaterials that induce surface plasmon effect for screening biomarkers various diseases ranging from cancer to Covid-19. The global pandemic re-confirmed trend real-time diagnosis public health be point-of-care (POC) settings can screen interested at home, or literally anywhere else, any time. Plasmonic biosensors, thanks its versatile designs and extraordinary sensitivities, scaled into small portable devices POC diagnostic tools. In meantime, efforts are being made speed up, simplify lower cost signal readout process including converting conventional heavy laboratory instruments lightweight handheld devices. This article reviews design plasmonic nanomaterial-based biomarker detection a perspective applications. After briefly introducing working mechanisms devices, selected highlights field focusing technology's development, structure assembly, target applications presented analyzed. parallel, discussions sensor's current potential applicability provided. Finally, challenges opportunities biosensor detection, such as Covid-19 testing using incorporation machine learning algorithms discussed.

Язык: Английский

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