Development of Nanocarrier-Based Radionuclide and Photothermal Therapy in Combination with Chemotherapy in Melanoma Cancer Treatment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(10), С. 13460 - 13471

Опубликована: Март 3, 2023

Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy. synthesized effectively labeled 188Re radionuclide radiolabeling efficiency (94-98%) radiochemical stability (>95%) appropriate for Further, 188Re-Au NRs, mediating conversion laser radiation into heat, were intratumorally injected PTT was applied. Upon irradiation near-infrared laser, dual achieved. Additionally, 188Re-labeled NRs paclitaxel (PTX) has improved (188Re-labeled irradiation, PTX) monoregime. Thus, this local triple-combination step toward clinical translation use treatment.

Язык: Английский

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Near‐Infrared Nanoparticle‐Mediated Photothermal Cancer Therapy: A Comprehensive Review of Advances in Monitoring and Controlling Thermal Effects for Effective Cancer Treatment

Nano Select, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

ABSTRACT Photothermal therapy (PTT) has emerged as a promising alternative to conventional cancer treatments such radiation therapy, chemotherapy, and surgery. PTT uses light‐absorbing nanomaterials induce localized hyperthermia selectively eliminate cells, thus offering advantages over traditional interventions. This literature review focuses on nanoparticles for PTT, their heating properties, functions in theragnostic applications photothermal treatment. It highlights the fundamental principles, recent spectroscopic developments diagnosis treatment monitoring, clinical advancements near‐infrared (NIR) nanoparticle‐mediated emerging numerical methods preclinical planning of PTT.

Язык: Английский

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Universal Chelator-Free Radiolabeling of Organic and Inorganic-Based Nanocarriers with Diagnostic and Therapeutic Isotopes for Internal Radiotherapy

Chemistry of Materials, Год журнала: 2022, Номер 34(14), С. 6593 - 6605

Опубликована: Июль 8, 2022

Biomedical application of various nanoparticles (NPs) for bioimaging and therapeutic purposes attracts huge interest. In particular, NPs can be used as nanocarriers radionuclides radiotherapy malignant neoplasms. However, most approaches NP radiolabeling are complicated, their transfer into clinical practice is difficult due to multistep process, limited reproducibility, lack an automated procedure. Here, we develop a universal method suitable (either organic or inorganic) internal B16-F10 melanoma tumors. The obtained (polylactide, silica, gold, iron oxide) were labeled with diagnostic (99mTc) (188Re) high efficiency (∼94–98%) radiochemical stability (>95%). After intratumoral administration, these 188Re-labeled mostly remained in the tumor, inhibiting tumor growth rate compared untreated absence any significant leakage radiolabeled healthy tissues (the liver, heart, kidneys, lungs, spleen) was confirmed by single-photon emission computed tomography (SPECT) direct radiometry analysis. Histological analysis revealed no abnormal changes organs after therapy (e.g., acute pathologic findings detected liver kidneys). As result, treatment mice led prolonged survival control group. Thus, our study provides general guidance use different types radionuclide therapy.

Язык: Английский

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Surface enhanced Raman scattering (SERS)-active bacterial detection by Layer-by-Layer (LbL) assembly all-nanoparticle microcapsules

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2022, Номер 650, С. 129547 - 129547

Опубликована: Июнь 22, 2022

Язык: Английский

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Exploring nanodiamonds: leveraging their dual capacities for anticancer photothermal therapy and temperature sensing

Nanoscale, Год журнала: 2024, Номер 16(32), С. 14994 - 15008

Опубликована: Янв. 1, 2024

Cancer has become a primary global health concern, which prompted increased attention towards targeted therapeutic approaches like photothermal therapy (PTT). The unique optical and magnetic properties of nanodiamonds (NDs) have made them versatile nanomaterials with promising applications in biomedicine. This comprehensive review focuses on the potential NDs as multifaceted platform for anticancer therapy, mainly focusing their dual functionality PTT temperature sensing. highlighted NDs' ability to enhance through hybridization or modification, underscoring adaptability delivering small molecule reagents effectively. Furthermore, NDs, particularly fluorescent (FNDs) negatively charged nitrogen-vacancy centers, enable precise monitoring, enhancing efficacy treatment. Integrating FNDs into holds promise advancing by providing valuable insights localized variations cell death mechanisms. highlights new cancer treatment strategies, showcasing revolutionize therapeutics improve patient outcomes.

Язык: Английский

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Fluorescence-based thermometry for precise estimation of nanoparticle laser-induced heating in cancerous cells at nanoscale

Nanophotonics, Год журнала: 2022, Номер 11(18), С. 4323 - 4335

Опубликована: Авг. 12, 2022

Photothermal therapy (PTT) has attracted increasing interest as a complementary method to be used alongside conventional therapies. Despite great number of studies in this field, only few have explored how temperatures affect the outcome PTT at nanoscale. In work, we study necrosis/apoptosis process cancerous cells that occurs during PTT, using combination local laser heating and nanoscale fluorescence thermometry techniques. The temperature distribution within whole cell was evaluated lifetime imaging microscopy laser-induced hyperthermia. For this, gold nanorods were utilized nanoheaters. near-infrared illumination produces gradient across cells, which is precisely measured by thermometry. This allows one optimize conditions varying concentration associated with power density. During procedure, such an approach enables accurate determination percentages apoptotic necrotic 2D 3D models. According performed experiments, influence increase on death mechanisms been verified determined. Our investigations can improve understanding its therapeutic efficiency while avoiding any side effects.

Язык: Английский

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Hybrid plasmonic nanodiamonds for thermometry and local photothermal therapy of melanoma: a comparative study

Nanophotonics, Год журнала: 2024, Номер 13(22), С. 4111 - 4125

Опубликована: Авг. 28, 2024

Abstract Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other modalities. During hyperthermia therapy, control is crucial. Here, we report on simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell ( NV@Au ) or densely covered NPs NV@SiO 2 @Au ). Such integration advantageous both for heating and precise thermometry at nanoscale. After structural optical investigations, abilities the obtained were thoroughly inspected glass, association living cells, tissue slices ex vivo , revealing their effective heat generation under excitation light using single source. The developed finally applied local photothermal therapy melanoma demonstrating efficacy eradicating cells monitoring during process.

Язык: Английский

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RETRACTED: Theoretical simulation and experimental design of selenium and gold incorporated polymer-based microcarriers for ROS-mediated combined photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 643, С. 232 - 246

Опубликована: Апрель 10, 2023

Язык: Английский

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Enhancing in vitro photothermal therapy using plasmonic gold nanorod decorated multiwalled carbon nanotubes

Biomedical Optics Express, Год журнала: 2023, Номер 14(12), С. 6629 - 6629

Опубликована: Ноя. 20, 2023

Photothermal therapy (PTT) is a promising approach for cancer treatment that selectively heats malignant cells while sparing healthy cells. Here, the light-to-heat conversion efficiency of multiwalled carbon nanotubes (MWCNTs) within near-infrared biological transmission window enhanced by decorating them with plasmonic gold nanorods (GNRs). The results reveal significant photothermal enhancement hybrid MWCNTs-GNRs compared to bare MWCNTs, displaying 4.9 factor per unit mass. PTT properties are also investigated in vitro using PC3 prostate cell lines, demonstrating potent ablation efficiency. These findings advance innovative nanostructures clinical applications.

Язык: Английский

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Design of millimeter-scale microwave-induced capsules and their non-instantaneous release

Materials & Design, Год журнала: 2023, Номер 226, С. 111663 - 111663

Опубликована: Фев. 1, 2023

In recent years, many studies have been carried out on the release system induced by microwave signal, featured with great thermal efficiency and high penetration. However, responsive millimeter length scale are limited, which is of importance due to its loading capacity widespread application. this study, novel microwave-induced capsules responsiveness in water-free environment, consisting paraffin shell supportive skeleton fibers were designed prepared. The detailed releasing behaviors, together morphology, systematically investigated. Non-instantaneous behavior consisted heating, melting core was observed, supported numerical simulations. key role different thickness confirmed kinetics releasing. profile can be well described a two-segment model, includes zero-order model cumulative distribution functions, corresponding diffusion controlled shell-melting processes, respectively.

Язык: Английский

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