Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 22, 2023
Abstract
Cancer
therapy
necessitates
the
development
of
novel
and
effective
treatment
modalities
to
combat
complexity
this
disease.
In
project,
we
propose
a
synergistic
approach
by
combining
chemo-photothermal
using
thiol-functionalized
gold
nanorods
(AuNRs)
supported
on
mesoporous
silica,
offering
promising
solution
for
enhanced
lung
cancer
therapy.
To
begin,
MCM-41
was
synthesized
surfactant-templated
sol-gel
method,
chosen
its
desirable
porous
structure,
excellent
biocompatibility,
non-toxic
properties.
Further,
achieved
through
simple
grafting
process,
enabling
subsequent
synthesis
thiol-MCM-41-functionalized
AuNRs
(AuNR@S-MCM-41)
via
gold-thiol
interaction.
The
nanocomposite
then
loaded
with
anticancer
drug
doxorubicin
(DOX),
resulting
in
AuNR@S-MCM-41-DOX.
Remarkably,
exhibited
pH/NIR
dual-responsive
release
behaviors,
facilitating
targeted
delivery.
addition,
it
demonstrated
exceptional
biocompatibility
efficient
internalization
into
A549
cells.
Notably,
combined
photothermal-
chemo
AuNR@S-MCM-41-DOX
superior
efficacy
killing
cells
compared
single
chemo-
or
photothermal
therapies.
This
study
showcases
potential
as
candidate
treatment.
innovative
integration
nanorods,
provides
comprehensive
therapeutic
improved
outcomes
Future
advancements
based
strategy
hold
promise
addressing
challenges
posed
transforming
patient
care.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 22, 2024
Abstract
Cancer
therapy
necessitates
the
development
of
novel
and
effective
treatment
modalities
to
combat
complexity
this
disease.
In
project,
we
propose
a
synergistic
approach
by
combining
chemo-photothermal
using
gold
nanorods
(AuNRs)
supported
on
thiol-functionalized
mesoporous
silica,
offering
promising
solution
for
enhanced
lung
cancer
therapy.
To
begin,
MCM-41
was
synthesized
surfactant-templated
sol–gel
method,
chosen
its
desirable
porous
structure,
excellent
biocompatibility,
non-toxic
properties.
Further,
achieved
through
simple
grafting
process,
enabling
subsequent
synthesis
AuNRs
(AuNR@S-MCM-41)
via
gold-thiol
interaction.
The
nanocomposite
then
loaded
with
anticancer
drug
doxorubicin
(DOX),
resulting
in
AuNR@S-MCM-41-DOX.
Remarkably,
exhibited
pH/NIR
dual-responsive
release
behaviors,
facilitating
targeted
delivery.
addition,
it
demonstrated
exceptional
biocompatibility
efficient
internalization
into
A549
cells.
Notably,
combined
photothermal-chemo
AuNR@S-MCM-41-DOX
superior
efficacy
killing
cells
compared
single
chemo-
or
photothermal
therapies.
This
study
showcases
potential
as
candidate
treatment.
innovative
integration
nanorods,
provides
comprehensive
therapeutic
improved
outcomes
Future
advancements
based
strategy
hold
promise
addressing
challenges
posed
transforming
patient
care.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
166, С. 115316 - 115316
Опубликована: Авг. 10, 2023
Melanoma
is
a
highly
aggressive
form
of
skin
cancer
with
limited
therapeutic
options.
Chemo-photothermal
combination
therapy
has
demonstrated
potential
for
effectively
treating
melanoma,
and
transdermal
administration
considered
the
optimal
route
diseases
due
to
its
ability
bypass
first-pass
metabolism
enhance
drug
concentration.
However,
stratum
corneum
presents
formidable
challenge
as
significant
barrier
penetration
in
delivery.
Lipid-nanocarriers,
particularly
cubosomes,
have
been
possess
augmenting
permeation
across
corneum.
Herein,
cubosomes
co-loaded
doxorubicin
(DOX,
chemotherapeutic
drug)
indocyanine
green
(ICG,
photothermal
agent)
(DOX-ICG-cubo)
delivery
system
was
developed
efficiency
melanoma
by
improving
permeation.
The
DOX-ICG-cubo
showed
high
encapsulation
both
DOX
ICG,
exhibited
good
stability
under
physiological
conditions.
In
addition,
unique
cubic
structure
confirmed
through
transmission
electron
microscopy
(TEM)
images,
polarizing
microscopy,
small
angle
X-ray
scattering
(SAXS).
presented
conversion
efficiency,
well
pH
thermo-responsive
release.
Notably,
enhanced
biocompatibility,
improved
vivo
anti-melanoma
efficacy
synergistic
effects
chemo-photothermal
therapy.
conclusion,
promising
strategy
treatment.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
651, С. 123763 - 123763
Опубликована: Янв. 2, 2024
Nanomaterials'
application
in
cancer
therapy
has
been
driven
by
their
ability
to
encapsulate
chemotherapeutic
drugs
as
well
reach
the
tumor
site.
Nevertheless,
nanomedicines'
translation
limited
due
lack
of
specificity
towards
cells.
Although
nanomaterials'
surface
can
be
coated
with
targeting
ligands,
such
mostly
achieved
through
non-covalent
functionalization
strategies
that
are
prone
premature
detachment.
Notwithstanding,
cells
often
establish
resistance
mechanisms
impair
effect
loaded
drugs.
This
bottleneck
may
addressed
using
near-infrared
(NIR)-light
responsive
nanomaterials.
The
NIR-light
triggered
hyperthermic
generated
these
nanomaterials
cause
irreversible
damage
or
sensitize
them
chemotherapeutics'
action.
Herein,
a
novel
covalently
functionalized
targeted
NIR-absorbing
nanomaterial
for
chemo-photothermal
was
developed.
For
such,
dopamine-reduced
graphene
oxide
were
bonded
hyaluronic
acid,
and
then
doxorubicin
(DOX/HA-DOPA-rGO).
produced
showed
suitable
physicochemical
properties,
high
encapsulation
efficiency,
photothermal
capacity.
vitro
studies
revealed
cytocompatible
display
an
improved
uptake
CD44-overexpressing
breast
Importantly,
combination
DOX/HA-DOPA-rGO
NIR
light
reduced
cells'
viability
just
23
%,
showcasing
potential
therapy.
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e35655 - e35655
Опубликована: Авг. 1, 2024
Melanoma,
a
lethal
form
of
skin
cancer,
poses
significant
challenge
in
oncology
due
to
its
aggressive
nature
and
high
mortality
rates.
Gold
nanostructures,
including
gold
nanoparticles
(GNPs),
offer
myriad
opportunities
melanoma
therapy
imaging
their
facile
synthesis
functionalization,
robust
stability,
tunable
physicochemical
optical
properties,
biocompatibility.
This
review
explores
the
emerging
role
nanostructures
composites
revolutionizing
treatment
paradigms,
bridging
gap
between
nanotechnology
clinical
oncology,
offering
insights
for
researchers,
clinicians,
stakeholders.
It
begins
by
elucidating
potential
nanotechnology-driven
approaches
cancer
therapy,
highlighting
unique
properties
versatility
GNPs
biomedical
applications.
Various
therapeutic
modalities,
photothermal
photodynamic
targeted
drug
delivery,
gene
nanovaccines,
are
discussed
detail,
along
with
from
ongoing
trials.
In
addition,
utility
theranostics
is
explored,
showcasing
diagnosis,
monitoring,
personalized
medicine.
Furthermore,
safety
considerations
toxicities
associated
addressed,
underscoring
importance
comprehensive
risk
assessment
translation.
Finally,
concludes
discussing
current
challenges
future
directions,
emphasizing
need
innovative
strategies
maximize
impact
therapy.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 22, 2024
Radionuclide
therapy
(RT)
is
widely
used
to
advanced
local
cancers.
However,
its
therapeutic
efficacy
limited
the
radiation
resistance
of
cancer
cells.
Combination
aims
circumvent
tumor
resistance,
and
combination
RT
with
photothermal
(PTT),
photodynamic
(PDT),
chemotherapy
(CMT),
immunotherapy
has
shown
promising
treatment
outcomes.
Nanotechnology
holds
promise
in
advancing
by
integrating
multiple
therapies
on
a
nanostructure
platform.
This
due
increased
surface
area,
passive/active
targeting
capabilities,
high
payload
capacity,
enriched
nanomedicines,
offering
significant
advantages
sensitivity
specificity.
In
first
part
this
review,
we
categorize
radionuclide
therapy.
The
second
summarizes
latest
developments
therapies,
specifically
focusing
integration
PTT,
PDT,
CMT
immunotherapy.
last
provides
an
overview
challenges
potential
opportunities
related
radionuclide-labelled
nanoparticles
for
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3643 - 3652
Опубликована: Март 1, 2025
Cuproptosis,
distinguished
from
apoptosis,
necroptosis,
pyroptosis,
and
ferroptosis,
is
a
current
form
of
programmed
cell
death
that
provides
novel
strategies
for
tumor
therapy.
Nanotechnology
inducing
cuproptosis
showed
potential
in
ablation.
However,
these
might
induce
cellular
damage
due
to
lack
tumor-targeting
ability
or
insufficient
inhibition
alone.
Here,
biomimetic
copper-doped
polydopamine
nanoparticles
(PC
NPs)
were
developed
specifically
enhance
radiotherapy
(RT).
PC
NPs
characterized
before
application
These
improve
targeting
accumulation.
After
entering
the
region,
degrades
cells
responsive
acidic
microenvironment
(TME).
Next,
Cu2+
reduced
Cu+
after
consuming
overexpressed
glutathione
(GSH),
which
induces
dihydrolipoamide
S-acetyltransferase
(DLAT)
aggression
cuproptosis.
Under
RT,
reactive
oxygen
species
(ROS)
are
generated
consume
GSH,
leading
The
decreasing
GSH
content
tissues
can
treatment
effect
RT
by
inhibiting
self-repair
cells,
hindering
survival
proliferation.
combination
alleviate
growth,
reaching
growth
rate
93.0%.
This
tumor-specific
nano
platform
valuable
radiosensitizer
TME
improving
therapeutic
efficacy
against
tumors.
