Biodegradable Microrobots and Their Biomedical Applications: A Review

Nanomaterials, Год журнала: 2023, Номер 13(10), С. 1590 - 1590

Опубликована: Май 9, 2023

During recent years, microrobots have drawn extensive attention owing to their good controllability and great potential in biomedicine. Powered by external physical fields or chemical reactions, these untethered microdevices are promising candidates for vivo complex tasks, such as targeted delivery, imaging sensing, tissue engineering, hyperthermia, assisted fertilization, among others. However, clinical use, the biodegradability of is significant avoiding toxic residue human body. The selection biodegradable materials corresponding environment needed degradation increasingly receiving this regard. This review aims at analyzing different types critically discussing advantages limitations. mechanisms behind typical applications also thoroughly investigated. Furthermore, we examine feasibility deal with suitability terms mechanisms; pathological environments; biomedical applications, especially delivery. Ultimately, highlight prevailing obstacles perspective solutions, ranging from manufacturing methods, control movement, rate insufficient limited tests, that could be benefit forthcoming applications.

Язык: Английский

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Dual-Oxygenation/Dual-Fenton Synergistic Photothermal/Chemodynamic/Starvation Therapy for Tumor Treatment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(12), С. 15129 - 15139

Опубликована: Март 15, 2023

Due to the complexity of tumor pathogenesis and heterogeneity microenvironment (TME), it is difficult obtain satisfactory efficacy with a single therapy. In this study, hyaluronic acid (HA)-modified ruthenium nanoaggregate (RuNA) glucose oxidase (GOD) -loaded manganese dioxide (MnO2) nanoflowers (MRG@HA) have been prepared. RuNA MnO2 can generate O2 in TME, alleviating tissue hypoxia. good photothermal agent for high-temperature ablation solid tumors under infrared laser irradiation. GOD consumes presence converts into glucuronic hydrogen peroxide, reducing nutrient supply while promoting Fenton-like reactions produce cytotoxic hydroxyl radicals. MRG@HA also actively target cells through affinity HA CD44 receptor improve antitumor effect. vitro vivo studies confirmed synergistic effect photothermal/chemodynamic/starvation therapy, showing its great potential clinical application

Язык: Английский

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Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

Nano Research, Год журнала: 2024, Номер 17(7), С. 6342 - 6352

Опубликована: Март 22, 2024

Язык: Английский

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Delivering Microrobots in the Musculoskeletal System

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 22, 2024

Disorders of the musculoskeletal system are major contributors to global burden disease and current treatments show limited efficacy. Patients often suffer chronic pain might eventually have undergo end-stage surgery. Therefore, future should focus on early detection intervention regional lesions. Microrobots been gradually used in organisms due their advantages intelligent, precise minimally invasive targeted delivery. Through combination control imaging systems, microrobots with good biosafety can be delivered desired area for treatment. In system, mainly utilized transport stem cells/drugs or remove hazardous substances from body. Compared traditional biomaterial tissue engineering strategies, active motion improves efficiency penetration local targeting cells/drugs. This review discusses frontier applications microrobotic systems different tissues system. We summarize challenges barriers that hinder clinical translation by evaluating characteristics finally point out direction

Язык: Английский

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MnO2 modified hollow mesoporous silica nanoparticles for enhanced chemodynamic therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105604 - 105604

Опубликована: Март 21, 2024

Язык: Английский

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