Dual-Oxygenation/Dual-Fenton Synergistic Photothermal/Chemodynamic/Starvation Therapy for Tumor Treatment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(12), С. 15129 - 15139

Опубликована: Март 15, 2023

Due to the complexity of tumor pathogenesis and heterogeneity microenvironment (TME), it is difficult obtain satisfactory efficacy with a single therapy. In this study, hyaluronic acid (HA)-modified ruthenium nanoaggregate (RuNA) glucose oxidase (GOD) -loaded manganese dioxide (MnO2) nanoflowers (MRG@HA) have been prepared. RuNA MnO2 can generate O2 in TME, alleviating tissue hypoxia. good photothermal agent for high-temperature ablation solid tumors under infrared laser irradiation. GOD consumes presence converts into glucuronic hydrogen peroxide, reducing nutrient supply while promoting Fenton-like reactions produce cytotoxic hydroxyl radicals. MRG@HA also actively target cells through affinity HA CD44 receptor improve antitumor effect. vitro vivo studies confirmed synergistic effect photothermal/chemodynamic/starvation therapy, showing its great potential clinical application

Язык: Английский

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Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

Nano Research, Год журнала: 2024, Номер 17(7), С. 6342 - 6352

Опубликована: Март 22, 2024

Язык: Английский

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Delivering Microrobots in the Musculoskeletal System

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 22, 2024

Disorders of the musculoskeletal system are major contributors to global burden disease and current treatments show limited efficacy. Patients often suffer chronic pain might eventually have undergo end-stage surgery. Therefore, future should focus on early detection intervention regional lesions. Microrobots been gradually used in organisms due their advantages intelligent, precise minimally invasive targeted delivery. Through combination control imaging systems, microrobots with good biosafety can be delivered desired area for treatment. In system, mainly utilized transport stem cells/drugs or remove hazardous substances from body. Compared traditional biomaterial tissue engineering strategies, active motion improves efficiency penetration local targeting cells/drugs. This review discusses frontier applications microrobotic systems different tissues system. We summarize challenges barriers that hinder clinical translation by evaluating characteristics finally point out direction

Язык: Английский

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Micro/Nanomotor‐Driven Intelligent Targeted Delivery Systems: Dynamics Sources and Frontier Applications

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(27)

Опубликована: Июль 29, 2024

Abstract Micro/nanomotors represent a promising class of drug delivery carriers capable converting surrounding chemical or external energy into mechanical power, enabling autonomous movement. Their distinct propulsive force distinguishes them from other carriers, offering significant potential for enhancing penetration across cellular and tissue barriers. A comprehensive understanding micro/nanomotor dynamics with various power sources is crucial to facilitate their transition proof‐of‐concept clinical application. In this review, micro/nanomotors are categorized three classes based on sources: endogenously stimulated, exogenously live cell‐driven. The review summarizes the mechanisms governing movements under these explores factors influencing motion. Furthermore, it discusses methods controlling movement, encompassing aspects related structure, composition, environmental factors. remarkable exhibited by makes valuable biomedical applications, including tumor therapy, bio‐detection, bacterial infection inflammation gastrointestinal disease remediation. Finally, addresses challenges prospects application micro/nanomotors. Overall, emphasizes transformative in overcoming biological barriers therapeutic efficacy, highlighting applications fields.

Язык: Английский

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MnO2 modified hollow mesoporous silica nanoparticles for enhanced chemodynamic therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105604 - 105604

Опубликована: Март 21, 2024

Язык: Английский

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