Glycol Chitosan-Poly(lactic acid) Conjugate Nanoparticles Encapsulating Ciprofloxacin: A Mucoadhesive, Antiquorum-Sensing, and Biofilm-Disrupting Treatment Modality for Bacterial Keratitis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(15), С. 18360 - 18385

Опубликована: Апрель 4, 2024

Bacterial keratitis (BK) causes visual morbidity/blindness if not treated effectively. Here, ciprofloxacin (CIP)-loaded nanoparticles (NPs) using glycol chitosan (GC) and poly(lactic acid) (PLA) conjugate at three different ratios (CIP@GC(PLA) NPs (1:1,5,15)) were fabricated. CIP@GC(PLA) (1:1) more effective than other tested ratios, indicating the importance of optimal hydrophobic/hydrophilic balance for corneal penetration preventing bacterial invasion. The realized highest association with human epithelial cells, which nonirritant to hen's egg-chorioallantoic membrane test (HET-CAM test) demonstrated significant antibacterial response in vitro minimum inhibitory, bactericidal, live-dead zone inhibition, biofilm inhibition assays against keratitis-inducing pathogen Pseudomonas aeruginosa. antiquorum sensing activity GC has been explored first time. disrupted quorum by inhibiting production virulence factors, including acyl homoserine lactones, pyocyanin, motility, caused downregulation associated genes. In vivo studies, displayed ocular retention (∼6 h) decreased opacity load Overall, NP is a biofilm-disrupting treatment regimen clinical translation potential BK.

Язык: Английский

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Surface antimicrobial functionalization with polymers: fabrication, mechanisms and applications

Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(45), С. 9349 - 9368

Опубликована: Янв. 1, 2022

Undesirable adhesion of microbes such as bacteria, fungi and viruses onto surfaces affects many industries marine, food, textile, healthcare. In particular in healthcare food packaging, the effects unwanted microbial contamination can be life-threatening. With current global COVID-19 pandemic, interest development with superior anti-viral anti-bacterial activities has multiplied. Polymers carrying anti-microbial properties are extensively used to functionalize material inactivate infection-causing biocide-resistant including COVID-19. This review aims introduce fabrication polymer-based antimicrobial through physical chemical modifications, followed by discussion inactivation mechanisms conventional biocidal agents new-generation macromolecules polymer-modified surfaces. The advanced applications on personal protective equipment against COVID-19, packaging materials, biomedical devices, marine vessels textiles also summarized express research trend academia industry.

Язык: Английский

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A novel acid-responsive polymer coating with antibacterial and antifouling properties for the prevention of biofilm-associated infections

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 239, С. 113939 - 113939

Опубликована: Май 2, 2024

Язык: Английский

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Dual-Action Defense: A photothermal and controlled nitric Oxide-Releasing coating for preventing biofilm formation

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 191 - 200

Опубликована: Окт. 20, 2024

Язык: Английский

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Bioinspired nanoflakes with antifouling and mechano-bactericidal capacity

Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 224, С. 113229 - 113229

Опубликована: Фев. 26, 2023

Язык: Английский

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