Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity

Small, Год журнала: 2023, Номер 19(42)

Опубликована: Июнь 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Язык: Английский

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Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101292 - 101292

Опубликована: Апрель 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Язык: Английский

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Transition metal-based nanozymes: Classification, catalytic mechanisms and emerging biomedical applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215771 - 215771

Опубликована: Март 17, 2024

Язык: Английский

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Progress and prospects of nanomaterials against resistant bacteria

Journal of Controlled Release, Год журнала: 2022, Номер 351, С. 301 - 323

Опубликована: Сен. 23, 2022

Язык: Английский

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Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging

Chemical Engineering Journal, Год журнала: 2023, Номер 463, С. 142293 - 142293

Опубликована: Март 6, 2023

Язык: Английский

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Colorimetric detection of uric acid based on enhanced catalytic activity of cobalt-copper bimetallic-modified molybdenum disulfide

Microchemical Journal, Год журнала: 2023, Номер 189, С. 108541 - 108541

Опубликована: Фев. 20, 2023

Язык: Английский

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Copper incorporated biomaterial-based technologies for multifunctional wound repair

Theranostics, Год журнала: 2023, Номер 14(2), С. 547 - 570

Опубликована: Дек. 5, 2023

The treatment of wounds is a worldwide challenge, and wound infection can affect the effectiveness further increase disease burden. Copper an essential trace element that has been shown to have broad-spectrum antibacterial effects be involved in inflammation, proliferation, remodeling stages healing. Compared treatments such as bioactive factors skin grafts, copper advantage being low-cost easily available, received lot attention Recently, biomaterials made by incorporating into glasses, polymeric scaffolds hydrogels used promote healing release ions. In addition, copper-incorporated with catalytic, photothermal, photosensitive properties also accelerate through microenvironment regulation. This review summarizes mechanisms copper- incorporated their roles healing, discusses current challenges. A comprehensive understanding role will help facilitate new preclinical clinical studies, thus leading development novel therapeutic tools.

Язык: Английский

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Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216205 - 216205

Опубликована: Сен. 11, 2024

Язык: Английский

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A Robust Photothermal-Mediated Nanozyme Engineering with Efficient Synergistic Antibacterial Therapy for Wound Healing

ACS Materials Letters, Год журнала: 2024, Номер 6(6), С. 2487 - 2496

Опубликована: Май 23, 2024

Nanozyme hybrids with photothermally mediated catalytic activity have received increasing attention in addressing the challenges of public health events caused by bacterial infections. However, designing photothermal nanozyme efficient synergistic antibacterial properties remains a challenge but is desirable. Herein, prepared CuxO@PDA (CP) showed excellent conversion efficiency 39.81%. More interestingly, CP also possesses peroxidase-like activity, which could convert H2O2 to •OH, and capability was improved under NIR irradiation. The effect between makes proposed therapy able kill 99.74% Staphylococcus aureus (S. aureus) 99.82% Escherichia coli (E. coli). In vivo experiments further that ability be well applied wound infection treatment. Overall, our work provides insight into design high-efficacy photothermal-mediated compounds for broad-spectrum applications.

Язык: Английский

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Nanozymes with biomimetically designed properties for cancer treatment

Nanoscale, Год журнала: 2024, Номер 16(16), С. 7786 - 7824

Опубликована: Янв. 1, 2024

The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.

Язык: Английский

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