Applied Materials Today, Год журнала: 2024, Номер 37, С. 102130 - 102130
Опубликована: Фев. 28, 2024
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(9), С. 12273 - 12293
Опубликована: Фев. 22, 2023
Ideal periosteum materials are required to participate in a sequence of bone repair-related physiological events, including the initial immune response, endogenous stem cell recruitment, angiogenesis, and osteogenesis. However, conventional tissue-engineered periosteal have difficulty achieving these functions by simply mimicking via structural design or loading exogenous cells, cytokines, growth factors. Herein, we present novel biomimetic preparation strategy comprehensively enhance regeneration effect using functionalized piezoelectric materials. The resulting possessing an excellent improved physicochemical properties was prepared biocompatible biodegradable poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) polymer matrix, antioxidized polydopamine-modified hydroxyapatite (PHA), barium titanate (PBT), which were further incorporated into matrix fabricate multifunctional simple one-step spin-coating method. addition PHA PBT dramatically enhanced biological periosteum, surface hydrophilicity roughness, mechanical performance, tunable degradation behavior, stable desired electrical stimulations, is conducive accelerating regeneration. Benefiting from stimulation bioactive components, as-fabricated demonstrated favorable biocompatibility, osteogenic activity, immunomodulatory vitro, not only promoted adhesion, proliferation, spreading as well osteogenesis mesenchymal cells (MSCs) but also effectively induced M2 macrophage polarization, thereby suppressing reactive oxygen species (ROS)-induced inflammatory reactions. Through vivo experiments, with synergistically accelerated formation new rat critical-sized cranial defect model. whole almost completely covered at 8 weeks post treatment, thickness close that host bone. Collectively, its properties, developed here represents method rapidly regenerate tissue stimulation.
Язык: Английский
Процитировано
58
Bioactive Materials, Год журнала: 2024, Номер 35, С. 274 - 290
Опубликована: Фев. 8, 2024
The healing process of critical-sized bone defects urges for a suitable biomineralization environment. However, the unsatisfying repair outcome usually results from disturbed intricate milieu and lack in situ mineralization resources. In this work, we have developed composite hydrogel that mimics natural processes serves as seedbed regeneration. oxidized silk fibroin fibrin are incorporated rigid geogrids, amorphous calcium phosphate (ACP) platelet-rich plasma serve fertilizers loam, respectively. Encouragingly, demonstrates excellent mechanical properties stable scaffold promotes vascularized regeneration vivo. Additionally, succinate-like function via PI3K-Akt signaling pathway subsequently orchestrates mitochondrial uptake, further converting exogenous ACP into endogenous ACP. realizes succession resources evolution biotemplate to collagen. Therefore, our work has established novel silk-based functions an in-situ seedbed, providing new insight defect
Язык: Английский
Процитировано
17
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.
Язык: Английский
Процитировано
2
Journal of Polymer Science, Год журнала: 2022, Номер 61(1), С. 7 - 43
Опубликована: Окт. 19, 2022
Abstract Polysaccharides possessing distinctive properties, such as biocompatibility, biodegradability, and nontoxicity, are promising matrices for hydrogels. However, the polysaccharides‐based hydrogels have poor mechanical which is a major limitation their applications. In recent years, researches on double‐network (DN) with outstanding properties gained increasing attention. Therefore, main research orientation to combine benefits of both materials broaden applications in various fields. This paper reviews progress polysaccharide‐based DN (PDN) that show great advantages mechanical, physiochemical biodegradability so on. The preparation, structure, unique different PDN discussed detail. Moreover, we summarize biomedical energy storage conversion breaking through limitations opening new avenue future development.
Язык: Английский
Процитировано
47
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Фев. 13, 2023
Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including tumors, trauma, and extensive fractures, where the self-healing property of cannot repair defect. is composed three main elements: progenitor/stem cells, scaffold, growth factors/biochemical cues. Among various biomaterial scaffolds, hydrogels are broadly used in owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, osteoinductive properties. During engineering, angiogenesis plays central role failure or success reconstruction via discarding wastes providing oxygen, minerals, nutrients, factors injured microenvironment. This review presents an overview its requirements, hydrogel structure characterization, applications regeneration, promising roles during engineering.
Язык: Английский
Процитировано
39
Composites Part B Engineering, Год журнала: 2023, Номер 252, С. 110505 - 110505
Опубликована: Янв. 5, 2023
Язык: Английский
Процитировано
32
Advanced Science, Год журнала: 2023, Номер 10(11)
Опубликована: Янв. 25, 2023
Abstract Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting‐edge glue developed in this study satisfies these criteria. Inspired by excellent adhesive properties of mussels, herein, super (L‐DPZ) that integrates poly(vinyl alcohol), L‐dopa amino acid, zeolitic imidazolate framework‐8 characterized catechol–metal coordination is used successfully adhere hard with maximum strength 10 MPa, which much higher than those commercial previously reported glues. stable adhesion also enables it strongly luxated or broken teeth, Bio‐Oss (a typical graft material), splice fragments from comminuted fractures rabbit femur. Then, testified L‐DPZ hydrogels exhibit satisfactory biocompatibility, degradability, ability vitro. Moreover, anchor sustained osteogenesis result healing calvarial defect models rabbits, as observed increased thickness ingrowth new tissue. These results are expected demonstrate solutions clinical dilemmas such fracture fixation, reconstruction, teeth dislocation replantation.
Язык: Английский
Процитировано
27
Heliyon, Год журнала: 2024, Номер 10(16), С. e36258 - e36258
Опубликована: Авг. 1, 2024
Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.
Язык: Английский
Процитировано
14
Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance
Язык: Английский
Процитировано
13
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150560 - 150560
Опубликована: Март 20, 2024
Язык: Английский
Процитировано
12