Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151756 - 151756

Опубликована: Апрель 30, 2024

Язык: Английский

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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 6, 2025

Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, common feature solid tumor, associated with drug resistance and poor prognosis in BC. In this study, we present strategy to overcome hypoxia-induced chemotherapy tolerance Specifically, synthesized hollow gold (Au)-platinum (Pt) bimetallic nanoshell for the first time, which acted as delivery system (DDS) doxorubicin (DOX). The photothermal effect, induced by surface plasmon resonance (SPR) from Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through therapy (PTT), but also significantly enhances catalase-like activity between Pt nanoparticles endogenous H2O2. This, subsequently, results heightened yield O2, further facilitates release DOX. This process alleviates hypoxia down-regulating hypoxia-inducible factor-1α (HIF-1α), multidrug gene 1 (MDR1), P-glycoprotein (P-gp), can reverse achieve more effective DOX effects. Significantly, increased availability oxygen re-polarizes immunosuppressive M2 macrophages into antitumor M1 macrophages. study presents novel tackle proliferation enhance response chemotherapy, offering hope reversing cancerous lesions.

Язык: Английский

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Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy

Small, Год журнала: 2023, Номер 19(50)

Опубликована: Авг. 26, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on UiO-66-NH2 are designed, then hybrid coated Mn-EGCG film, further wrapped HA to obtain final nanocomposite @Mn3 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses inflammatory site synovium, stimulation microwave (MW) irradiation low trigger slow dissociation film. Then endogenously overexpressed hydrogen peroxide (H2 disintegrates exposed Mn3 NPs promote ROS scavenging generation. Assisted MW irradiation, microenvironment down-regulates expression hypoxia-inducible factor-1α (HIF-1α). Coupled clearance ROS, it promotes re-polarization M1 phenotype into anti-inflammatory (M2) macrophages. Therefore, multifunctional nanoplatform, IMN, exhibits promising potential modulate restore has exciting prospect treatment RA.

Язык: Английский

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A bright future: Advanced nanotechnology-assisted microwave therapy

Nano Today, Год журнала: 2023, Номер 52, С. 101963 - 101963

Опубликована: Авг. 12, 2023

Язык: Английский

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Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis

Bioactive Materials, Год журнала: 2024, Номер 36, С. 83 - 95

Опубликована: Март 1, 2024

Abnormal proliferation of aggressive fibroblast-like synoviocytes (FLS) and perpetuate synovial inflammation can inevitably accelerate the progression rheumatoid arthritis (RA). Herein, a strategy simultaneously promoting FLS apoptosis inhibiting as mediated by macrophages is proposed to restore homeostasis for effective RA therapy. A hyaluronic acid-based dissolvable microneedle (MN) fabricated transdermal delivery dual human serum albumin (HSA)-contained biomimetic nanocomplexes regulate macrophages. Upon skin insertion, are released rapidly from MN accumulate in joint microenvironment through both passive active targeting HSA. Thioketal-crosslinked fluorinated polyethyleneimine 1.8 K (TKPF) was constructed bind plasmid encoding pro-apoptotic gene PUMA with HSA coating layer (TKPF/pPUMA@HSA, TPH). TPH upregulate transfection trigger efficient apoptosis. Also, encapsulating classic anti-inflammatory natural product celastrol (Cel@HSA, CH) inhibit blocking NF-κB pathway activation. TPH/CH deplete M1 macrophage activation, suppress hyperplasia well reduce bone cartilage erosion collagen-induced (CIA) mouse model, demonstrating promising treatment.

Язык: Английский

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Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 18, 2024

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinical utility limited water insolubility, poor permeability, low bioavailability. To address these challenges, we developed multifunctional drug delivery system—adipose-derived stem cells-exosomes (ADSCs-EXO)-ICA to target macrophages in synovial tissue modulate macrophage polarization M1 M2. High-performance liquid chromatography analysis confirmed 92.4 ± 0.008% loading efficiency for ADSCs-EXO-ICA. In vitro studies utilizing cellular immunofluorescence (IF) flow cytometry demonstrated significant inhibition of proliferation Enzyme-linked immunosorbent assay, transcriptomics, real-time quantitative PCR indicated that ADSCs-EXO-ICA promotes an M1-to-M2 phenotypic transition reducing glycolysis through ERK/HIF-1α/GLUT1 pathway. vivo, effectively accumulated joints. Pharmacodynamic assessments revealed decreased cytokine levels mitigated symptoms collagen-induced (CIA) rats. Histological micro computed tomography markedly ameliorated preserved cartilage. Further vivo suppresses promoting switch suppressing glycolysis. Western blotting supported therapeutic efficacy RA, confirming role modulating function energy metabolism regulation. Thus, this study not only introduces system significantly enhances anti-RA but also elucidates mechanism action inhibition. Graphical abstract

Язык: Английский

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Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Язык: Английский

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Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 22, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate pathogenesis. In RA, repeated monotherapy frequently associated inadequate efficacy, drug resistance, severe side effects. Therefore, a shift has occurred in clinical practice toward combination therapy. However, conventional therapy encounters several hindrances, including low selectivity to arthritic joints, short half-lives, varying pharmacokinetics among coupled drugs. Emerging nanotechnology offers incomparable opportunity for developing advanced against RA. First, it allows co-delivering multiple drugs augmented physicochemical properties, targeted delivery capabilities, controlled release profiles. Second, enables therapeutic nanomaterials development, thereby expanding regimens include multifunctional nanomedicines. Lastly, facilitates the construction of all-in-one nanoplatforms assembled modalities, such as phototherapy, sonodynamic therapy, imaging. Thus, promising solution current bottleneck both RA treatment diagnosis. This review summarizes rationale, advantages, recent advances nano-empowered It also discusses safety considerations, drug–drug interactions, potential translation. Additionally, provides design tips outlook on future developments The objective this achieve comprehensive understanding mechanisms underlying unlock maximum nanotechnology, facilitating smooth transition research findings from laboratory practice.

Язык: Английский

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Mild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 22, 2024

Abstract Background Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts body, which leads to a deterioration local microenvironment. This degradation marked elevated levels uric acid (UA), increased reactive oxygen species (ROS) production, hypoxic conditions, an upsurge in pro-inflammatory mediators, and mitochondrial dysfunction. Results In this study, we developed multifunctional nanoparticle polydopamine-platinum (PDA@Pt) combat acute gout leveraging mild hyperthermia synergistically enhance UA anti-inflammatory effect. Herein, PDA acts as foundational template that facilitates growth Pt shell on surface its nanospheres, leading formation PDA@Pt nanomedicine. Within therapeutic agent, catalyzes decomposition actively breaks down endogenous hydrogen peroxide (H 2 O ) produce , helps alleviate conditions. Concurrently, component possesses exceptional capacity for ROS scavenging. Most significantly, Both exhibit absorption Near-Infrared-II (NIR-II) region, not only endow with superior photothermal conversion efficiency effective therapy (PTT) but also substantially enhances nanomedicine’s degradation, production scavenging enzymatic activities. photothermally-enhanced approach effectively repair damage downregulates NF-κB signaling pathway inhibit expression cytokines. Conclusions The nanomedicine exhibits efficacy reduction effects, presenting promising potential strategy management gout. Graphical

Язык: Английский

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Bibliometric and visualization analysis of the application of inorganic nanomaterials to autoimmune diseases

Biomaterials Science, Год журнала: 2024, Номер 12(16), С. 3981 - 4005

Опубликована: Янв. 1, 2024

Bibliometric analysis of the application inorganic nanomaterials to autoimmune diseases is used characterize current research trends and visualize past emerging in this field 15 years.

Язык: Английский

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