Food Chemistry, Год журнала: 2024, Номер 467, С. 142343 - 142343
Опубликована: Дек. 5, 2024
Язык: Английский
Materials Today Chemistry, Год журнала: 2024, Номер 40, С. 102233 - 102233
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
15
ACS Nano, Год журнала: 2024, Номер 18(6), С. 4783 - 4795
Опубликована: Фев. 1, 2024
Contrast-enhanced magnetic resonance imaging (CE-MRI) of acute kidney injury (AKI) is severely hindered by the poor targeting capacity and potential toxicity current contrast agents. Herein, we propose one-step fabrication a bovine serum albumin@polydopamine@Fe (BSA@PDA@Fe, BPFe) nanoprobe with self-purification for targeted CE-MRI AKI. BSA endows BPFe renal tubule-targeting ability, PDA capable completely inhibiting intrinsic metal-induced reactive oxygen species (ROS), which are always involved in Fe/Mn-based The as-prepared owns tiny size 2.7 nm, excellent solubility, good T1 MRI superior biocompatibility, powerful antioxidant capacity. In vivo shows that can accumulate cortex due to reabsorption effect toward albumin. AKI model, impaired function be effortlessly detected via diminishment cortical signal enhancement. More importantly, administration would not aggravate damage outstanding Besides, employed CE-MR angiography visualize fine vessel structures. This work provides an agent biosafety ability diseases.
Язык: Английский
Процитировано
12
Small, Год журнала: 2024, Номер unknown
Опубликована: Май 15, 2024
Abstract Periodontitis is the leading cause of adult tooth missing. Thorny bacterial biofilm and high reactive oxygen species (ROS) levels in tissue are key elements for periodontitis process. It meaningful to develop an advanced therapeutic system with sequential antibacterial/ antioxidant ability meet overall goals therapy. Herein, a dual‐polymer functionalized melanin‐AgNPs (P/D‐MNP‐Ag) penetration, hydroxyapatite binding, sequentially treatment fabricated. Polymer enriched 2‐(Dimethylamino)ethyl methacrylate (D), can be protonated acid environment enhanced positive charge, promoting penetration biofilm. The other polymer rich phosphate group (P) chelate Ca 2+ , adhere surface. Melanin has good ROS scavenging photothermal abilities, after situ reduction Ag, composite transitioned between antibacterial antioxidative due heat accelerated Ag + release. released have synergistic effects killing. With consumption, MNP recovers scavenge inflammatory area. When applied model, P/D‐MNP‐Ag therapeutical ablate biofilm, relieve inflammation state, reduce alveolar bone loss. provides reference developing oral eradication systems.
Язык: Английский
Процитировано
11
Analytical Chemistry, Год журнала: 2024, Номер 96(8), С. 3318 - 3328
Опубликована: Фев. 14, 2024
Contrast-enhanced magnetic resonance imaging (CE-MRI) is a promising approach for the diagnosis of kidney diseases. However, safety concerns, including nephrogenic systemic fibrosis, limit administration gadolinium (Gd)-based contrast agents (GBCAs) in patients who suffer from renal impairment. Meanwhile, nanomaterials meet biosafety concerns because their long-term retention body. Herein, we propose small-molecule manganese-based probe Mn-PhDTA as an alternative to GBCAs assess insufficiency first time. was synthesized via simple three-step reaction with total yield up 33.6%, and gram-scale synthesis can be realized. has r1 relaxivity 2.72 mM–1 s–1 at 3.0 T superior kinetic inertness over Gd-DTPA Mn-EDTA dissociation time 60 min presence excess Zn2+. In vivo vitro experiments demonstrate good stability biocompatibility. unilateral ureteral obstruction rats, provided significant MR signal enhancement, enabled distinguishing structure changes between normal damaged kidneys, evaluated function different injured stages. could act potential MRI agent candidate replacement early detection dysfunction analysis disease progression.
Язык: Английский
Процитировано
9
Materials, Год журнала: 2024, Номер 17(12), С. 2870 - 2870
Опубликована: Июнь 12, 2024
Magnetic nanoparticles (MNPs) have found extensive application in the biomedical domain due to their enhanced biocompatibility, minimal toxicity, and strong magnetic responsiveness. MNPs exhibit great potential as nanomaterials various applications, including disease detection cancer therapy. Typically, consist of a core surrounded by surface modification coatings, such inorganic materials, organic molecules, polymers, forming nucleoshell structure that mitigates nanoparticle agglomeration enhances targeting capabilities. Consequently, responsiveness vivo for transportation therapeutic effects, enhancing medical imaging resolution localized heating at site injury. are utilized specimen purification through targeted binding separation vitro, thereby optimizing efficiency expediting process. This review delves into distinctive functional characteristics well diverse bioactive molecules employed coatings corresponding functionalities. Additionally, advancement applications is outlined. we discuss advancements imaging, treatment, vitro assays, anticipate future development prospects obstacles this field. The objective furnish readers with thorough comprehension recent practical utilization disciplines.
Язык: Английский
Процитировано
7
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)
Опубликована: Янв. 27, 2024
Abstract Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity gadolinium‐based contrast agents (GBCAs). Nevertheless, there is an extreme shortage highly sensitive renal clearable iron suitable for early damage detection through MRI. Herein, a ultra‐small ferrite nanoprobe (UMFNPs@ZDS) proposed diagnosis via structural functional MRI vivo first time. The comprises core coated with zwitterionic layer, possesses high T 1 relaxivity (12.52 m −1 s ), small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, impressive ability. In rat model unilateral ureteral obstruction (UUO), nanoprobe‐based not only accurately visualize locations injury, but also provide comprehensive data including peak value, time, relative function (RRF), clearance percentage findings prove immense as superior alternative to GBCAs damage.
Язык: Английский
Процитировано
5
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(8)
Опубликована: Янв. 4, 2024
Ischemia-induced myocardial injury has become a serious threat to human health, and its treatment remains challenge. The occurrence of ischemic events leads burst release reactive oxygen species (ROS), which triggers extensive oxidative damage dysfunctional autophagy, making it difficult for cells maintain homeostasis. Antioxidants modulation autophagy have thus promising strategies the injury. This study proposes an antioxidant-activated therapeutic regimen based on combining melanin (Mel), excellent antioxidant with metformin mimetic ploymetformin via electrostatic interactions, obtain nanocomplex (Met-Mel). is finally encapsulated platelet membranes (PMN) construct biomimetic nanoparticle (PMN@Met-Mel) capable targeting injured myocardium. prepared PMN@Met-Mel good Mel loading capacity optimal biosafety. It exhibits activity activation, rapidly restoring mitochondrial function. Moreover, RNA sequencing (RNA-seq) analysis reveals that operates mechanistically by triggering activation pathway. Subsequent in vivo experiments showcase cardioprotective effects these nanoparticles. These discoveries present newly devised nanoplatform potential effective infarction.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140451 - 140451
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(5), С. 5474 - 5485
Опубликована: Янв. 25, 2024
Contrast-enhanced magnetic resonance imaging (MRI) is seriously limited in kidney injury detection due to the nephrotoxicity of clinically used gadolinium-based contrast agents. Herein, we propose a noninvasive method for assessment by combining structure and function information based on manganese (Mn)-enhanced MRI first time. As proof concept, Mn-melanin nanoprobe with good biocompatibility excellent T1 relaxivity applied unilateral ureteral obstruction mice model. The abundant renal obtained through qualitative quantitative analysis MR images, brand new comprehensive framework proposed precisely identify degree successfully. Our study demonstrates that Mn-enhanced promising approach highly sensitive biosafe vivo.
Язык: Английский
Процитировано
3
American Journal of Nephrology, Год журнала: 2024, Номер 55(3), С. 334 - 344
Опубликована: Янв. 1, 2024
<b><i>Introduction:</i></b> Renal fibrosis (RF), being the most important pathological change in progression of CKD, is currently assessed by evaluation a biopsy. This present study aimed to apply novel functional MRI (fMRI) protocol named amide proton transfer (APT) weighting evaluate RF noninvasively. <b><i>Methods:</i></b> Male Sprague-Dawley (SD) rats were initially subjected bilateral kidney ischemia/reperfusion injury (IRI), unilateral ureteral obstruction, and sham operation, respectively. All underwent APT mapping on 7th 14th days after operation. Besides, 26 patients renal biopsy at Nephrology Department Shanghai Tongji Hospital between July 2022 May 2023. Patients apparent diffusion coefficient (ADC) mappings within 1 week before results both calculated comparing with gold standard histology for assessment. <b><i>Results:</i></b> In animal models, cortical (cAPT) medullary (mAPT) values positively correlated degree RF. Compared group, IRI group showed significantly increased cAPT mAPT surgery, but no differences found ADC values. Similar human patients. Cortical/medullary moderate-to-severe than mild fibrosis. ROC curve analysis indicated that value displayed better diagnostic Furthermore, combination cADC improved detection imaging variables alone (<i>p</i> < 0.1). <b><i>Conclusion:</i></b> had capability early stage compared values, addition conventional will improve performance predicting
Язык: Английский
Процитировано
2