Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101687 - 101687
Опубликована: Март 20, 2025
Repairing
bone
defects
in
inflammatory
conditions
remains
a
significant
clinical
challenge.
An
ideal
scaffold
material
for
such
situations
should
enable
minimally
invasive
implantation
and
integrate
capabilities
immunomodulation,
anti-infection
therapy,
enhanced
regeneration.
In
this
study,
we
developed
injectable
calcitriol@polydopamine@gelatin
methacryloyl
hydrogel
microspheres
(CAL@PDA@GMs)
using
microfluidic
technology.
This
system
facilitates
the
sustained
release
of
calcitriol,
which
features
excellent
biocompatibility
biodegradability,
promotes
osteogenesis,
scavenges
excessive
reactive
oxygen
species
(ROS),
induces
polarization
macrophages
from
M1
to
M2
phenotype,
thereby
mitigating
lipopolysaccharide
(LPS)-induced
inflammation.
These
mechanisms
work
synergistically
create
an
optimal
immune
microenvironment
regeneration
conditions.
RNA
sequencing
(RNA-Seq)
analyses
revealed
that
immunomodulation
is
achieved
by
regulating
macrophage
phenotypes,
inhibiting
nuclear
transcription
factor-kappa
B
(NF-κB)
ROS
signaling
pathways,
reducing
secretion
pro-inflammatory
cytokines.
study
proposes
novel
method
enhance
tissue
remediating
damaged
presents
potential
therapeutic
strategy
large-scale
injuries.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 305 - 320
Опубликована: Май 8, 2024
Osteochondral
regeneration
involves
the
highly
challenging
and
complex
reconstruction
of
cartilage
subchondral
bone.
Silicon
(Si)
ions
play
a
crucial
role
in
bone
development.
Current
research
on
Si
mainly
focuses
repair,
by
using
silicate
bioceramics
with
ion
compositions.
However,
it
is
unclear
whether
have
important
effect
regeneration.
Developing
scaffold
that
solely
releases
to
simultaneously
promote
repair
stimulate
critically
important.
Diatomite
(DE)
natural
diatomaceous
sediment
can
stably
release
ions,
known
for
its
abundant
availability,
low
cost,
environmental
friendliness.
Herein,
hierarchical
osteochondral
uniquely
designed
incorporating
gradient
DE
into
GelMA
hydrogel.
The
adding
microparticles
provides
specific
source
controlled
release,
which
not
only
promotes
osteogenic
differentiation
rBMSCs
(rabbit
marrow
mesenchymal
stem
cells)
but
also
enhances
proliferation
maturation
chondrocytes.
Moreover,
DE-incorporated
scaffolds
significantly
promoted
study
suggests
significant
promoting
solidifies
their
foundational
enhancing
repair.
Furthermore,
offers
an
economic
eco-friendly
strategy
developing
high
value-added
regenerative
bioscaffolds
from
low-value
ocean
materials.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Июнь 1, 2023
Natural
bone
tissue
possesses
inherent
electrophysiological
characteristics,
displaying
conductivity
and
piezoelectricity
simultaneously;
hence,
the
reconstruction
of
local
electrical
microenvironment
at
defect
site
provides
an
effective
strategy
to
enhance
osteogenesis.
Herein,
a
composite
cryogel-type
scaffold
(referred
as
Gel-PD-CMBT)
is
developed
for
regeneration,
utilizing
gelatin
(Gel)
in
combination
with
conductive
poly(ethylene
dioxythiophene)/polystyrene
sulfonate
matrix
Ca/Mn
co-doped
barium
titanate
(CMBT)
nanofibers
piezoelectric
filler.
The
incorporation
these
components
results
formation
integrated
piezoelectric/conductive
network
within
scaffold,
facilitating
charge
migration
yielding
0.59
S
cm-1
.
This
creates
promising
electroactive
microenvironment,
which
capable
up-regulating
biological
responses.
Furthermore,
interconnected
porous
structure
Gel-PD-CMBT
not
only
mechanical
stability
but
also
offered
ample
space
cellular
ingrowth.
demonstrates
greater
capacity
promote
osteogenic
differentiation
vitro
neo-bone
vivo.
In
summary,
its
conductivity,
effectively
restores
offering
ideal
platform
regeneration
tissue.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 130998 - 130998
Опубликована: Март 22, 2024
Although
calcium‑magnesium
phosphate
cements
(CMPCs)
have
been
widely
applied
to
treating
critical-size
bone
defects,
their
repair
efficiency
is
unsatisfactory
owing
weak
surface
bioactivity
and
uncontrolled
ion
release.
In
this
study,
we
lyophilized
alginate
sodium
(AS)
as
a
coating
for
HAp/K-struvite
(H@KSv)
develop
AS/HAp/K-struvite
(AH@KSv),
which
promotes
regeneration.
The
compressive
strength
hydrophilicity
of
AH@KSv
significantly
improved,
leading
enhanced
cell
adhesion
in
vitro.
Importantly,
the
SA
enables
continuous
ions
release
Mg2+
Ca2+,
finally
osteogenesis
vitro/vivo
different
patterns
new
growth
vivo.
Furthermore,
these
composites
increased
expression
levels
biomarkers
TRPM7/PI3K/Akt
signaling
pathway
via
an
equilibrium
effect
Ca2+.
conclusion,
our
study
provides
novel
insights
into
mechanisms
Mg-based
biomaterials
Macromolecular Rapid Communications,
Год журнала:
2023,
Номер
44(19)
Опубликована: Июль 5, 2023
Photodynamic
therapy
(PDT)
has
emerged
as
a
promising
cancer
treatment
modality;
however,
its
therapeutic
efficacy
is
greatly
limited
by
tumor
hypoxia.
In
this
study,
metal-organic
framework
(MOF)-based
hydrogel
(MOF
Gel)
system
that
synergistically
combines
PDT
with
the
supply
of
oxygen
designed.
Porphyrin-based
Zr-MOF
nanoparticles
are
synthesized
photosensitizer.
MnO2
decorated
onto
surface
MOF,
which
can
effectively
convert
H₂O₂
into
oxygen.
Simultaneously,
incorporation
-decorated
MOF
(MnP
NPs)
chitosan
serves
to
enhance
stability
and
retention
at
site.
The
results
show
integrated
approach
significantly
improves
inhibition
efficiency
relieving
hypoxia
enhancing
PDT.
Overall,
findings
underscore
potential
for
employing
nano-MOF-based
systems
agents
therapy,
thus
advancing
application
multifunctional
MOFs
in
treatment.
Regenerative Medicine,
Год журнала:
2024,
Номер
19(5), С. 257 - 278
Опубликована: Май 3, 2024
Bioactive
ceramics,
primarily
consisting
of
bioactive
glasses,
glass–ceramics,
calcium
orthophosphate
silicate
ceramics
and
carbonate
have
received
great
attention
in
the
past
decades
given
their
biocompatible
nature
excellent
bioactivity
stimulating
cell
proliferation,
differentiation
tissue
regeneration.
Recent
studies
tried
to
combine
with
ions,
polymers,
proteins
other
chemicals
improve
mechanical
biological
properties,
thus
rendering
them
more
valid
engineering
scaffolds.
This
review
presents
beneficial
properties
potential
applications
ceramic-based
materials
dentistry,
particularly
repair
regeneration
dental
hard
tissue,
pulp–dentin
complex,
periodontal
bone
tissue.
Moreover,
greater
insights
into
mechanisms
development
are
provided.
