Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 419 - 434
Опубликована: Авг. 30, 2024
Язык: Английский
Bioactive Materials, Год журнала: 2023, Номер 32, С. 445 - 472
Опубликована: Окт. 26, 2023
Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.
Язык: Английский
Процитировано
45
Advanced Science, Год журнала: 2024, Номер 11(26)
Опубликована: Май 5, 2024
Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune pathway to elicit robust response cancer immunotherapy. Furthermore, doping BG endows system excellent photothermal properties, hence facilitating STING activation reversing immune‐suppressive microenvironment. exhibits favorable angiogenic capacity tissue regenerative potential, promotes cell migration vitro. When combining BG‐Mn anti‐PD‐1 antibody (α‐PD‐1) melanoma, it shows enhanced long‐term memory response. Remarkably, upregulate expression genes related blood vessel formation promote skin regeneration when treating full‐thickness wounds. Overall, Gel serves an effective adjuvant therapy regulate
Язык: Английский
Процитировано
20
Biomaterials Science, Год журнала: 2024, Номер 12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,
Язык: Английский
Процитировано
18
Advanced Functional Materials, Год журнала: 2024, Номер 34(17)
Опубликована: Янв. 3, 2024
Abstract Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number advantages in cancer therapy owing its porous structure, large specific surface area, tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome hypoxia significantly enhance the anti‐tumor effect. In this review, hypoxic characteristics tumors current strategies for constructing that are summarized, including delivering O 2 or endogenously generating elevate intra‐tumor content; inhibiting HIF‐1 induced products alleviate hypoxia; reducing cellular aerobic respiration decrease consumption, exacerbating improve efficacy hypoxia‐activated pre‐drugs. At same time, applications applied different therapeutic methods at present stage described, finally, challenges opportunities further development discussed.
Язык: Английский
Процитировано
17
Gels, Год журнала: 2025, Номер 11(1), С. 76 - 76
Опубликована: Янв. 18, 2025
Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(33), С. 43156 - 43170
Опубликована: Авг. 12, 2024
Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in biomedical field based on advantages internal porosity, customizable facile surface modification. This review examines utilization drug delivery systems, focusing research progress from aspects coloading intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, multifunctional living carriers. In addition, current challenges faces also discussed. The aims to provide a reference for further application as advanced systems.
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137047 - 137047
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125328 - 125328
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(44), С. 10566 - 10594
Опубликована: Янв. 1, 2023
As a new multifunctional soft substance, MOGs have been used as excellent carriers or smart materials in the pharmaceutical field.
Язык: Английский
Процитировано
7
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 419 - 434
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
0