The development of nanocarriers for natural products

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)

Опубликована: Май 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Язык: Английский

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Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152849 - 152849

Опубликована: Июнь 5, 2024

Язык: Английский

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Enzyme/ROS dual-sensitive nanoplatform with on-demand Celastrol release capacity for enhanced ulcerative colitis therapy by ROS scavenging, microbiota rebalancing, inflammation alleviating

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 26, 2024

The oral administration of drugs for treating ulcerative colitis (UC) is hindered by several factors, including inadequate gastrointestinal stability, insufficient accumulation in colonic lesions, and uncontrolled drug release.

Язык: Английский

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Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(4), С. 100943 - 100943

Опубликована: Июль 14, 2024

Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, other side effects, hindering them from exerting their therapeutic effects. Colon-targeted delivery systems represent attractive alternatives as novel carriers for IBD treatment. This review mainly discusses treatment status IBD, obstacles delivery, design strategies colon-targeted systems, perspectives on existing complementary therapies. based recent reports, we summarized mechanism delivery. Finally, addressed challenges future directions facilitate exploitation advanced nanomedicine therapy.

Язык: Английский

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Gastric acid-responsive deformable sodium alginate/Bletilla striata polysaccharide in situ gel for the protection and treatment of alcohol-induced peptic ulcers

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 258, С. 128815 - 128815

Опубликована: Дек. 17, 2023

Язык: Английский

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The angelica Polysaccharide: a review of phytochemistry, pharmacology and beneficial effects on systemic diseases

International Immunopharmacology, Год журнала: 2024, Номер 133, С. 112025 - 112025

Опубликована: Апрель 26, 2024

Язык: Английский

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Orally deliverable lutein nanoparticles as robust ROS scavenger for dry eye disease by targeting Peyer’s patches and mitochondria of ocular cell

Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 153024 - 153024

Опубликована: Июнь 10, 2024

Язык: Английский

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An efficient co-delivery system based on multilayer structural nanoparticles for programmed sequential release of resveratrol and vitamin D3 to combat dextran sodium sulfate-induced colitis in mice

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127962 - 127962

Опубликована: Ноя. 10, 2023

Язык: Английский

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Passerini polymerization of α-lipoic acid for dynamically crosslinking 1,2-dithiolane-functionalized polymers

Chemical Communications, Год журнала: 2024, Номер 60(40), С. 5270 - 5273

Опубликована: Янв. 1, 2024

Passerini polymerization using naturally occurring α-lipoic acid as a raw material yields polyamides with 1,2-dithiolane functional groups in one-step reaction. The polyamide exhibits characteristics of an adaptable dynamically crosslinked network through reversible ring-opening reaction 1,2-dithiolane, enabling self-healing, reusable strong adhesion, and regeneration decrosslinking re-crosslinking.

Язык: Английский

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Construction of hyaluronic acid-functionalized magnolol nanoparticles for ulcerative colitis treatment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131920 - 131920

Опубликована: Апрель 26, 2024

Язык: Английский

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