Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15764 - 15764

Опубликована: Окт. 30, 2023

Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability encapsulated compounds but also provide efficient targeting reduce risk toxicity. Over last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, herbs have received more attention due their remarkable biological pharmacological health medical benefits. However, poor aqueous solubility, compromised stability, insufficient absorption, accelerated elimination impede research in nutraceutical sector. Owing possibilities offered by various LNPs, ability accommodate both hydrophilic hydrophobic molecules availability preparation methods suitable for sensitive molecules, loading natural fragile into LNPs offers a promising solution. The primary objective this work is explore synergy between nature nanotechnology, encompassing wide range aimed at encapsulating therapeutic within LNPs.

Язык: Английский

---

The bioengineering application of hyaluronic acid in tissue regeneration and repair

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132454 - 132454

Опубликована: Май 18, 2024

Язык: Английский

---

Glycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 158 - 178

Опубликована: Май 29, 2024

Язык: Английский

---

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Авг. 1, 2024

Abstract Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal (EMP). cells with EMP manifest in three states as transition (EMT), partial EMT, mesenchymal–epithelial transition, orchestrate switch heterogeneity tumor via transcriptional regulation series signaling pathways, transforming growth factor‐β, Wnt/β‐catenin, Notch. However, due complicated nature EMP, diverse process not fully understood. In this review, we systematically conclude biological background, regulating mechanisms well role therapy response. We also summarize range small molecule inhibitors, immune‐related approaches, combination therapies that have been developed target for outstanding EMP‐driven deterioration. Additionally, explore potential technique EMP‐based mechanistic investigation research, may burst vigorous prospects. Overall, elucidate multifaceted aspects progression suggest promising direction treatment based on targeting EMP.

Язык: Английский

---

Active Targeting Hyaluronan Conjugated Nanoprobe for Magnetic Particle Imaging and Near-Infrared Fluorescence Imaging of Breast Cancer and Lung Metastasis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(21), С. 27055 - 27064

Опубликована: Май 17, 2024

A major contributing cause to breast cancer related death is metastasis. Moreover, metastasis often shows little symptoms until a large area of the organs occupied by metastatic cells. Breast multimodal imaging attractive since it integrates advantages from several modalities, enabling more accurate detection. Glycoprotein CD44 overexpressed on most cells and primary cell surface receptor for hyaluronan (HA). To facilitate diagnosis, we report an indocyanine green (ICG) HA conjugated iron oxide nanoparticle (NP-ICG-HA), which enabled active targeting HA-CD44 interaction detected with magnetic particle (MPI) near-infrared fluorescence (NIR-FI). When evaluated in transgenic mouse model, NP-ICG-HA detection multiple tumors MPI NIR-FI, providing comprehensive images diagnosis cancer. Furthermore, NP-ICG-HAs were lung model. Upon administration, showed clear signals lungs, indicating tumor sites. This first time that HA-based NPs have are platform noninvasive

Язык: Английский

---

Hyaluronic acid-conjugated lipid nanocarriers in advancing cancer therapy: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 299, С. 140146 - 140146

Опубликована: Янв. 20, 2025

Язык: Английский

---

Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140144 - 140144

Опубликована: Янв. 21, 2025

Язык: Английский

---

Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells

Biomedical Materials, Год журнала: 2024, Номер 19(2), С. 025026 - 025026

Опубликована: Янв. 12, 2024

Abstract Hepatocellular carcinoma remains a challenging contributor to the global cancer and related mortality, claims approximately 800,000 deaths each year. Dysregulation or loss of function mutations involving tumor suppressor gene, phosphatase tensin homolog deleted on chromosome ten (PTEN), has been well-characterized in various cancers elicit anomalous cell proliferation oncogenic transformation. However, delivery bioavailability genes/drugs interest carcinomas serious bottleneck behind success any anti-cancer formulation. In this study, we have engineered nanoliposomes containing PTEN plasmids, plumbagin, antioxidant cerium oxide nanoparticles (Lipo-PTEN-Plum) restore expression inhibit AKT/PI3K pathway. The Lipo-PTEN-Plum was quasi-spherical shape with ∼110 nm diameter ∼64% plumbagin loading efficiency. successfully internalized HepG2 cells, PI3K/AKT pathway induce death cells grown monolayer form spheroids. Mechanistically, formulation showed G2/M cycle arrest, DNA damage apoptosis hepatic cells. Other cellular events such as Caspase-7 overexpression PI3K (phosphoinositide 3-kinase), AKT (a serine/threonine protein kinase), PARP [Poly (ADP-ribose) polymerases], mTOR (Mammalian target rapamycin) inhibition led mRNA profile PTEN, PI3K, AKT3, Caspase-7, proteins, primarily controlling apoptosis, suggest that exogenous supply could regulate proteins thus progression.

Язык: Английский

---

Co-assembly of cisplatin and dasatinib in hyaluronan nanogel to combat triple negative breast cancer with reduced side effects

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132074 - 132074

Опубликована: Май 3, 2024

Язык: Английский

---

Comprehensive review of Hesperetin: Advancements in pharmacokinetics, pharmacological effects, and novel formulations

Fitoterapia, Год журнала: 2024, Номер 179, С. 106206 - 106206

Опубликована: Сен. 8, 2024

Язык: Английский

---