Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Magnetism and Magnetic Materials, Год журнала: 2025, Номер 620, С. 172889 - 172889
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
0
Nano Today, Год журнала: 2025, Номер 62, С. 102706 - 102706
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
The advancement of imaging technologies plays a crucial role in improving the diagnosis and monitoring diseases, including cancer. This study introduces new design iron oxide-based nanoparticles specifically developed for magnetic particle (MPI), aimed at tracking diagnosing breast cancer more effectively. By precisely controlling size, shape, properties these nanoparticles, we enhance responsiveness MPI, resulting an increased signal. In our research, established novel synthetic route fabricating oxide nanochains (FeONCs) characterized by their uniform shape which contribute to high suitable MPI applications. Initial results indicate FeONCs exhibit superior compared conventional spherical superparamagnetic nanocubes, reported nanoworm-type structures. Magnetic relaxometry studies revealed that provide higher sensitivity than commonly used VivoTrax Synomag D50 D70 MPI. Further, size significantly influence cellular uptake. vivo experiments using orthotopic mouse models allow us assess biocompatibility characteristics confirming efficacy. Furthermore, conjugating with RGD peptide, ability target cancer, establishing them as promising tracers applications sensitivity. Thus, findings highlight improve quality, facilitating early detection accurate paves way innovative diagnostic strategies personalized treatment options. Future research will focus on fine-tuning surface chemistry further targeting efficiency optimization practice clinical applications, particularly MPI-based hyperthermia therapy.
Язык: Английский
Процитировано
0
Foods, Год журнала: 2024, Номер 13(17), С. 2812 - 2812
Опубликована: Сен. 4, 2024
Efficient drug delivery methods are crucial in modern pharmacotherapy to enhance treatment efficacy, minimize adverse effects, and improve patient compliance. Particularly the context of glioblastoma treatment, there has been a recent surge interest using natural dietary components as innovative carriers for delivery. These food-derived carriers, known their safety, biocompatibility, multifunctional properties, offer significant potential overcoming limitations conventional systems. This article thoroughly overviews numerous components, such polysaccharides, proteins, lipids, used carriers. Their mechanisms action, applications different systems, specific benefits targeting examined. Additionally, regulatory considerations employing food formulations discussed, highlighting viability future prospects pharmaceutical field.
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
Cancer-related anemia (CRA), a complication of cancer, is considered the primary cause high mortality for cancer patients. Safe and effective theranostics are desirable realizing diagnostic accuracy tumors ameliorating CRA in clinic. However, available do not support dual-modal imaging amelioration at same time. In this study, we synthesized functionalized iron oxide nanoparticles (Fe3O4 NPs) modified with protoporphyrin IX (PPIX) folic acid (FA) by one-step modification strategy (Fe3O4@NH-PPIX&FA or step-by-step (Fe3O4@NH-PPIX-FA NPs), aiming both magnetic resonance imaging/fluorescence (MRI/FI) erythropoiesis. Fe3O4@NH-PPIX-FA NPs displayed better ability MRI/FI than Fe3O4@NH-PPIX&FA had an efficient tumor targeting 45 min after tail vein injection owing to reduction steric effect extension FA groups. exhibited satisfactory erythropoiesis up 20% elevation red blood cell (RBC) counts hemoglobin concentrations mice CRA, which provided safe alternative RBC transfusions, especially patients needing recurrent transfusions. With excellent performance erythropoiesis, could be powerful tool anemia.
Язык: Английский
Процитировано
1
ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(32), С. 11928 - 11939
Опубликована: Авг. 2, 2024
Glyconanoparticles have a wide range of applications, from bioseparation to vaccine development. However, obtaining glyconanoparticles with magnetic response still presents some challenges, such as achieving high chemical stability, good dispersibility, and proper functional group density enhance the affinity recognition capability toward target molecules without losing their response. Additionally, there is growing need use synthetic methods that minimal impact on environment human health. This consideration significant for nanomaterials due intensive they are experiencing. study one-pot functionalization approach in aqueous mild conditions enables efficient conjugation de-O-acetylation carbohydrates iron oxide nanoparticles intermediate purification steps. The process demonstrates versatility joining different sugars-azide (peracetylated β-d-glucose-azide, peracetylated β-d-galactose-azide, α-d-mannose-azide), it was evaluated using green chemistry metrics, indicating improved sustainability compared conventional methods. reduces toxicity increases Green Star area index (GSAI) 20% (conventional method) 60% (one-pot method). attributed safer materials, water reaction medium, fewer Furthermore, offers operational simplicity enhanced safety those previously reported
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0