Acta Biomaterialia, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Small, Год журнала: 2023, Номер 20(16)
Опубликована: Ноя. 28, 2023
Abstract Photodynamic therapy (PDT) has recently been considered a potential tumor due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response causing immunogenic cell death of cells. Although it exhibits promising prospect in treating tumors, there are still many problems be solved practical application. Tumor hypoxia immunosuppressive microenvironment seriously affect the efficacy PDT. The hypoxic is mainly abnormal vascular matrix around tumor, metabolism, influence various immunosuppressive‐related their expressed molecules. Thus, reprogramming (TME) great significance for rejuvenating This article reviews latest strategies PDT, from regulating matrix, interfering with related factors reverse microenvironment. These provide valuable information better understanding TME guide development next‐generation multifunctional nanoplatforms
Язык: Английский
Процитировано
28
Advanced Functional Materials, Год журнала: 2024, Номер 34(27)
Опубликована: Фев. 25, 2024
Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.
Язык: Английский
Процитировано
15
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2023, Номер 657, С. 799 - 810
Опубликована: Дек. 6, 2023
Язык: Английский
Процитировано
12
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(3), С. 1526 - 1536
Опубликована: Фев. 21, 2024
Tumoral thermal defense mechanisms considerably attenuate the therapeutic outcomes of mild-temperature photothermal therapy (PTT). Thus, developing a simple, efficient, and universal strategy to sensitize PTT is desirable. Herein, we report self-delivery nanomedicines ACy NPs comprising near-infrared (NIR) agent (Cypate), mitochondrial oxidative phosphorylation inhibitor (ATO), distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE–PEG2000), which have high drug-loading efficiency that can reverse tumoral resistance, thereby increasing efficacy. achieved targeted tumor accumulation performed NIR fluorescence imaging capability in vivo guide for optimized outcomes. The released ATO reduced intracellular ATP levels downregulate multiple heat shock proteins (including HSP70 HSP90) before PTT, reversed resistance cells, contributing excellent results vitro vivo. Therefore, this study provides biosafe, advanced, protein-blocking PTT.
Язык: Английский
Процитировано
5
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 26, 2024
Abstract As an emerging cancer treatment strategy, reactive oxygen species-based tumor catalytic therapies face enormous challenges due to hypoxia and the overexpression of glutathione (GSH) in microenvironment. Herein, a self-assembled copper-based nanoplatform, TCCHA, was designed for enzyme-like catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma. TCCHA fabricated from Cu 2+ , 3,3′-dithiobis (propionohydrazide), photosensitizer chlorine e6 via facile one-pot self-assembly after which aldehyde hyaluronic acid coated, followed by loading antivascular drug AL3818. The obtained nanoparticles exhibited pH/GSH dual-responsive release behaviors multienzymatic activities, including Fenton, peroxidase-, catalase-like activities. redox homeostasis disruptor, promotes ⋅OH generation GSH depletion, thus increasing efficacy chemodynamic therapy. has activity, can also reinforce photodynamic therapy amplifying O 2 production. In vivo, efficiently inhibited angiogenesis suppressed growth without apparent systemic toxicity. Overall, this study presents strategy preparation multienzyme-like nanoparticles, display great potential enzyme triple cancer. Graphical
Язык: Английский
Процитировано
4
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 14, 2024
Abstract Due to the limitations of single-model tumor therapeutic strategies, multimodal combination therapy have become a more favorable option enhance efficacy by compensating for its deficiencies. However, in nanomaterial-based therapeutics tumors, exploiting synergistic interactions and cascade relationships materials achieve effective treatments is still great challenge. Based on this, we constructed nanoplatform with “triple-linkage” effect cleverly integrating polydopamine (PDA), silver nanoparticles (AgNPs), glucose oxidase (GOx) realize enhanced photothermal (PTT) activatable metal ion (MIT) hepatocellular carcinoma (HCC) treatment. First, non-radiative conversion PDA under light conditions was AgNPs, which directly efficiency PDA. In addition, GOx reduced synthesis cellular heat shock proteins interfering energy metabolism, thereby enhancing sensitivity PTT. On other hand, H 2 O , by-product GOx-catalyzed glucose, could be used as an activation source activate non-toxic AgNPs release cytotoxic Ag + achieving -mediated MIT. conclusion, this nanosystem achieved efficient PTT MIT HCC among PDA, GOx, providing novel idea design systems regulation. Graphical abstract
Язык: Английский
Процитировано
3
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(30), С. 39021 - 39034
Опубликована: Июль 21, 2024
Chemodynamic therapy (CDT), employing metal ions to transform endogenous H2O2 into lethal hydroxyl radicals (•OH), has emerged as an effective approach for tumor treatment. Yet, its efficacy is diminished by glutathione (GSH), commonly overexpressed in tumors. Herein, a breakthrough strategy involving extracellular vesicle (EV) mimetic nanovesicles (NVs) encapsulating iron oxide nanoparticles (IONPs) and β-Lapachone (Lapa) was developed amplify intracellular oxidative stress. The combination, NV-IONP-Lapa, created through serial extrusion from ovarian epithelial cells showed excellent biocompatibility leveraged magnetic guidance enhance endocytosis cancer cells, resulting selective generation Lapa catalysis NADPH quinone oxidoreductase 1 (NQO1). Meanwhile, the released IONPs ionization under acidic conditions triggered conversion of •OH Fenton reaction. Additionally, process eliminated GSH tumor, further amplifying designed NV-IONP-Lapa demonstrated exceptional targeting, facilitating MR imaging, enhanced suppression without significant side effects. This study presents promising NV-based drug delivery system exploiting CDT against NQO1-overexpressing tumors augmenting intratumoral
Язык: Английский
Процитировано
3
Small, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Chemodynamic therapy (CDT) has garnered significant attention in the field of tumor due to its ability convert overexpressed hydrogen peroxide (H 2 O ) tumors into highly toxic hydroxyl radicals (•OH) through metal ion‐mediated catalysis. However, effectiveness CDT is hindered by low catalyst efficiency, insufficient intra‐tumor H level, and excessive glutathione (GSH). In this study, a pH/GSH dual responsive bimetallic nanocatalytic system (CuFeMOF@GOx@Mem) developed modifying red blood cell membranes onto glucose oxidase (GOx)‐loaded Fe‐Cu MOFs, enhancing efficacy triple‐enhanced way self‐supply, catalysts self‐cycling, GSH self‐elimination. Upon accumulation tissues facilitated membrane, GOx initiates reaction with generate gluconic acid situ. Subsequently, reduced pH triggers release Fe 3+ Cu 2+ from CuFeMOF@GOx@Mem, which immediately turned + GSH, activating ‐mediated Fenton reaction. More importantly, can also act as an accelerator /Fe conversion, meanwhile, generated be further GSH. Consequently, sustained well elimination are achieved simultaneously, providing unique approach for improving anti‐tumor CDT.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Sublethal tumor cells have an urgent need for energy, making it common them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) compensatory energy supply; thus, the synchronous interference of dual pathways limiting level is essential in inhibiting sublethal growth. Herein, a multifunctional nanoplatform Co-MOF-loaded anethole trithione (ADT) myristyl alcohol (MA), modified with GOx hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere including OXPHOS restrict adenosine triphosphate (ATP) supply, achieving inhibition tumors after microwave (MW) thermal therapy. Under low-power MW irradiation, CAMGH induced certain damage while ensuring safety surrounding normal tissues. The loaded consumed glucose tumors, undoubtedly blocking main supply pathway, glycolytic pathway. Then, H
Язык: Английский
Процитировано
0