Abstract
Oncolytic
viruses
(OVs)
have
emerged
as
a
powerful
tool
in
cancer
therapy.
Characterized
with
the
unique
abilities
to
selectively
target
and
lyse
tumor
cells,
OVs
can
expedite
induction
of
cell
death,
thereby
facilitating
effective
eradication.
Nanoengineering‐derived
overcome
traditional
OV
therapy
limitations
by
enhancing
stability
viral
circulation,
targeting,
promising
improved
clinical
safety
efficacy
so
on.
This
review
provides
comprehensive
analysis
multifaceted
mechanisms
through
which
engineered
suppress
progression.
It
initiates
concise
delineation
on
fundamental
attributes
existing
OVs,
followed
exploration
their
antitumor
response.
Amid
rapid
advancements
nanomedicine,
this
presents
an
extensive
overview
latest
developments
synergy
between
nanomaterials,
nanotechnologies,
highlighting
characteristics
properties
nanomaterials
employed
potential
spur
innovation
novel
virus
design.
Additionally,
it
delves
into
current
challenges
emerging
field
proposes
strategies
these
obstacles,
aiming
design
application
next‐generation
OVs.
Photodynamic
therapy
(PDT)
is
a
temporally
and
spatially
precisely
controllable,
noninvasive,
potentially
highly
efficient
method
of
phototherapy.
The
three
components
PDT
primarily
include
photosensitizers,
oxygen,
light.
employs
specific
wavelengths
light
to
active
photosensitizers
at
the
tumor
site,
generating
reactive
oxygen
species
that
are
fatal
cells.
Nevertheless,
traditional
have
disadvantages
such
as
poor
water
solubility,
severe
oxygen-dependency,
low
targetability,
difficult
penetrate
deep
tissue,
which
remains
toughest
task
in
application
clinic.
Here,
we
systematically
summarize
development
molecular
mechanisms
challenges
management,
highlighting
advantages
nanocarriers-based
against
cancer.
third
generation
has
opened
up
new
horizons
PDT,
cooperation
between
nanocarriers
attained
satisfactory
achievements.
Finally,
clinical
studies
discussed.
Overall,
present
an
overview
our
perspective
field
believe
this
work
will
provide
insight
into
tumor-based
PDT.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Май 7, 2024
Immunotherapy
has
emerged
as
a
promising
cancer
treatment
option
in
recent
years.
In
immune
“hot”
tumors,
characterized
by
abundant
cell
infiltration,
immunotherapy
can
improve
patients’
prognosis
activating
the
function
of
cells.
By
contrast,
“cold”
tumors
are
often
less
sensitive
to
owing
low
immunogenicity
tumor
cells,
an
inhibitory
microenvironment,
and
series
immune-escape
mechanisms.
Immunogenic
death
(ICD)
is
cellular
process
facilitate
transformation
eliciting
innate
adaptive
responses
through
release
(or
exposure
to)
damage-related
molecular
patterns.
Accumulating
evidence
suggests
that
various
traditional
therapies
induce
ICD,
including
chemotherapy,
targeted
therapy,
radiotherapy,
photodynamic
therapy.
this
review,
we
summarize
biological
mechanisms
hallmarks
ICD
introduce
some
newly
discovered
technologically
innovative
inducers
activate
system
at
level.
Furthermore,
also
discuss
clinical
applications
combing
with
immunotherapy.
This
review
will
provide
valuable
insights
into
future
development
ICD-related
combination
therapeutics
potential
management
for
tumors.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(6), С. 3673 - 3692
Опубликована: Май 8, 2024
Copper
(Cu)
and
Cu-based
nanomaterials
have
received
tremendous
attention
in
recent
years
because
of
their
unique
physicochemical
properties
good
biocompatibility
the
treatment
various
diseases,
especially
cancer.
To
date,
researchers
designed
fabricated
a
variety
integrated
nanocomplexes
with
distinctive
nanostructures
applied
them
cancer
therapy,
mainly
including
chemotherapy,
radiotherapy
(RT),
photothermal
therapy
(PTT),
chemodynamic
(CDT),
photodynamic
(PDT),
cuproptosis-mediated
etc.
Due
to
limited
effect
single
method,
development
composite
diagnostic
nanosystems
that
integrate
PTT,
CDT,
PDT,
other
treatments
is
great
significance
offers
potential
for
next
generation
anticancer
nanomedicines.
In
view
rapid
field
this
review
focuses
on
current
state
research
nanomaterials,
followed
by
discussion
combined
therapy.
Moreover,
challenges
future
prospects
clinical
translation
are
proposed
provide
some
insights
into
design
nanotherapeutic
platforms.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 5, 2024
The
curative
effect
of
single
therapy
for
advanced
cholangiocarcinoma
(CCA)
is
poor,
thus
investigating
combined
treatment
strategies
holds
promise
improving
prognosis.
Surufatinib
(SUR)
a
novel
multikinase
inhibitor
that
has
been
confirmed
to
prolong
survival
patients
with
CCA.
Photodynamic
(PDT)
can
also
ablate
CCA
and
relieve
biliary
obstruction.
In
this
study,
we
explored
the
anti-CCA
SUR
PDT,
underlying
mechanism.
We
found
could
effectively
inhibit
abilities
proliferation,
migration
metastasis
in
cells
(HUCCT-1,
RBE).
ability
was
by
HUCCT-1
cell
xenograft
model
Balb/c
nude
mice
patient-derived
organoids.
PDT
significantly
enhance
inhibitory
on
CCA,
be
alleviated
two
ferroptosis
inhibitors
(Ferrostatin-1,
Deferoxamine).
By
detecting
level
reactive
oxygen
species,
lipid
peroxides,
malondialdehyde
glutathione,
further
inducing
ferroptosis.
Glutathione
peroxidase
4
(GPX4)
belongs
glutathione
family
mainly
responsible
metabolism
intracellular
hydrogen
peroxide.
GPX4
inhibits
reducing
cytotoxic
peroxides
(L-OOH)
corresponding
alcohols
(L-OH).
Acyl-CoA
synthetase
long-chain
member
(ACSL4)
fatty
acid
coenzyme
involved
biosynthesis
catabolism
acids.
ACSL4
induces
promoting
accumulation
peroxides.
Both
induce
inhibiting
GPX4.
regulation
more
significant
group.
conclusion,
exerted
an
Combination
provides
new
idea
clinical
Chemical Science,
Год журнала:
2024,
Номер
15(28), С. 10969 - 10979
Опубликована: Янв. 1, 2024
We
have
developed
a
series
of
novel
single
AIE
fluorophores
based
on
the
N
,
-diaryl
dihydrophenazine
moiety,
which
possess
anti-quenching
properties
and
can
be
utilized
for
efficient
in
vivo
bioimaging
cancer
phototherapy.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Photodynamic
therapy
(PDT)
is
a
powerful
strategy
for
tumor
with
noninvasiveness
and
desirable
efficacy.
However,
the
phototoxicity
of
photosensitizer
after
post‐PDT
major
obstacle
limiting
clinic
applications.
Herein,
nitric
oxide
(NO)‐activatable
reported
turn‐on
PDT
behavior
endoplasmic
reticulum
(ER)
targeting
ability
precise
therapy.
Four
o
‐thiophenediamine
derivatives
reaction‐tunable
donor/acceptor
push‐pull
electronic
effect
are
established,
systematic
structure
property
relationship
observation
reveals
following
features:
1)
reactivity
against
NO
can
be
improved
by
enhancing
electron
density
further
facilitated
upon
photo‐irradiation.
2)
enables
intramolecular
charge
transfer
process
evoking
photosensitizing
effect.
3)
only
derivative
ER
enrichment
exhibited
cancer
cell
ablation
compared
to
photosensitizers
localized
in
lysosome
lipid
droplet.
Thus,
efficient
inhibition
cells
both
vitro
vivo
realized
based
on
photo‐controlled
strategy.
This
work
provides
more
insights
into
developing
promising
activatable
advanced
microenvironment
trigger.
