Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Abstract
Gas
therapy
represents
a
promising
strategy
for
cancer
treatment,
with
nitric
oxide
(NO)
showing
particular
potential
in
tumor
therapy.
However,
ensuring
sufficient
production
of
NO
remains
significant
challenge.
In
this
study,
we
successfully
constructed
ultrasound-responsive
nanoparticles,
which
consisted
poly
(D,
L-lactide-co-glycolic
acid)
(PLGA)
natural
L-arginine
(LA),
and
superparamagnetic
iron
nanoparticles
(SPIO,
Fe3O4
NPs),
denote
as
Fe3O4-LA-PLGA
NPs.
The
NPs
exhibited
effective
therapeutic
effects
both
in
vitro
vivo,
particularly
NO-assisted
antitumor
gas
dual-modality
imaging
properties.
Upon
exposure
to
ultrasound
irradiation,
LA
were
rapidly
released
from
the
PLGA
It
was
demonstrated
that
could
spontaneously
react
hydrogen
peroxide
(H2O2)
present
microenvironment
generate
Concurrently,
H2O2
produce
substantial
quantity
reactive
oxygen
species
(ROS),
can
oxidize
further
facilitate
release
NO.
conclusion,
proposed
delivery
platform
exhibits
effectively
inhibiting
growth
breast
cancer.
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
ABSTRACT
Imaging‐guided
phototherapy
holds
promise
for
precision
cancer
treatment.
However,
most
photosensitizers
have
only
a
singular
modality
of
photodynamic
therapy
(PDT)
or
photothermal
(PTT),
which
make
their
therapeutic
efficacy
severely
limited
by
the
hypoxic
and
complex
tumor
microenvironment
(TME).
In
this
article,
we
provide
smart
platform
design
(BOD‐D)
based
on
visualized
light‐triggered
phototherapeutic
switch
transforming
from
near‐infrared
(NIR)‐I
imaging‐guided
PDT
to
activatable
NIR‐II‐guided
PTT
while
releasing
nitric
oxide
(NO)
gas
(GT).
BOD‐D
releases
native
NIR
one‐region
fluorescence
signals
in
tumors,
is
used
direct
robust
killing.
As
administered,
decreasing
oxygen
content
TME
becomes
progressively
insufficient
maintain
its
excellent
cell‐killing
effect.
Subsequently,
light
triggers
dissociation
NO
BOD‐D,
activating
agent
BOD‐T
that
emits
NIR‐II
fluorescence,
subsequent
PTT.
Notably,
not
light‐mediated
mechanism
can
be
switched
NIR‐I‐guided
PTT,
but
also
released
during
process
will
GT
sensitize
above
Our
study
contributes
intelligent
cascade
photoablation.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(6), С. 2447 - 2474
Опубликована: Март 18, 2024
The
clinical
efficacy
of
current
cancer
therapies
falls
short,
and
there
is
a
pressing
demand
to
integrate
new
targets
with
conventional
therapies.
Autophagy,
highly
conserved
self-degradation
process,
has
received
considerable
attention
as
an
emerging
therapeutic
target
for
cancer.
With
the
rapid
development
nanomedicine,
nanomaterials
have
been
widely
utilized
in
therapy
due
their
unrivaled
delivery
performance.
Hence,
considering
potential
benefits
integrating
autophagy
nanotechnology
therapy,
we
outline
latest
advances
autophagy-based
nanotherapeutics.
Based
on
brief
background
related
nanotherapeutics
impact
tumor
progression,
feasibility
treatment
demonstrated.
Further,
developed
modulate
are
reviewed
from
perspective
cell
signaling
pathways,
including
modulation
mammalian
rapamycin
(mTOR)
pathway,
autophagy-related
(ATG)
its
complex
expression,
reactive
oxygen
species
(ROS)
mitophagy,
interference
autophagosome-lysosome
fusion,
inhibition
hypoxia-mediated
autophagy.
In
addition,
combination
which
nano-autophagy
combined
chemotherapy,
phototherapy,
immunotherapy
also
described.
Finally,
prospects
challenges
efficient
envisioned.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Photothermal
therapy
(PTT)
represents
a
groundbreaking
approach
to
targeted
disease
treatment
by
harnessing
the
conversion
of
light
into
heat.
The
efficacy
PTT
heavily
relies
on
capabilities
photothermal
agents
(PTAs).
Among
PTAs,
those
based
organic
dyes
exhibit
notable
characteristics
such
as
adjustable
absorption
wavelengths,
high
extinction
coefficients,
and
compatibility
in
biological
systems.
However,
challenge
associated
with
dye‐based
PTAs
lies
their
efficiency
converting
heat
while
maintaining
stability.
Manipulating
dye
aggregation
is
key
aspect
modulating
non‐radiative
decay
pathways,
aiming
augment
generation.
This
review
delves
various
strategies
aimed
at
improving
performance
through
constructing
aggregation.
These
including
protecting
from
photodegradation,
inhibiting
non‐photothermal
space
within
molecular
aggregates,
introducing
intermolecular
photophysical
processes.
Overall,
this
highlights
precision‐driven
assembly
promising
frontier
enhancing
PTT‐related
applications.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanomedicine
for
Oncologic
Disease
Diagnostic
Tools
In
Vivo
Nanodiagnostics
Imaging
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
515, С. 215921 - 215921
Опубликована: Май 21, 2024
Nitric
oxide
(NO)
is
an
important
biochemical
molecule
that
endogenously
produced
to
act
for
instance
as
neurotransmitter,
effect
cell
growth,
or
regulate
the
immune
response.
Therapeutic
treatment
with
exogeneous
NO
difficult
owing
its
gaseous
and
reactive
nature
and,
not
surprising,
specific
molecules
deliver
have
been
developed.
Amongst
various
triggers
deliberately
release
from
these
NO-releasing
molecules,
light
most
elegant
allows
a
high
degree
of
control
over
time
location
NO-release.
For
therapeutic
applications,
it
necessary
use
long-wavelength
light,
preferably
in
red
near
infrared
region,
which
challenging
achieve.
This
review
gives
overview
on
approaches
red-shift
activation
wavelength
light-activated
NO-release
nitrosoamines,
o-substituted
nitroarenes,
L-arginine,
cupferron,
nitrosyl
metal
complexes.
While
focusing
single
photon
excitation
events,
direct
mechanisms
are
covered
well
photoelectron
transfer,
energy
chemiluminescence
photothermal
light-triggered
oxidation
pathways.
each
NO-releaser
class,
photochemical
mechanism
discussed,
biological
applications
mentioned.
Biomacromolecules,
Год журнала:
2024,
Номер
25(9), С. 5592 - 5608
Опубликована: Авг. 8, 2024
Nitric
oxide
(NO),
a
gasotransmitter,
is
known
for
its
wide
range
of
effects
in
vasodilation,
cardiac
relaxation,
and
angiogenesis.
This
diatomic
free
radical
also
plays
pivotal
role
reducing
the
risk
platelet
aggregation
thrombosis.
Furthermore,
NO
demonstrates
promising
potential
cancer
therapy
as
well
antibacterial
antibiofilm
activities
at
higher
concentrations.
To
leverage
their
biomedical
activities,
numerous
donors
have
been
developed.
Among
these,
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(13)
Опубликована: Дек. 21, 2023
Abstract
Almost
all
cancer
treatments
are
significantly
limited
by
the
strong
tumor
microenvironment
(TME)
fortress
formed
abnormal
vasculature,
dense
extracellular
matrix
(ECM),
multidrug
resistance
(MDR)
system,
and
immune
“cold”
environment.
In
huge
efforts
of
dismantling
TME
fortress,
nitric
oxide
(NO)‐based
nanomedicines
increasingly
occupying
a
central
position
have
already
been
identified
as
super
“strong
polygonal
warriors”
to
dismantle
for
efficient
treatment,
benefiting
from
NO's
unique
physicochemical
properties
extremely
fascinating
biological
effects.
However,
there
is
paucity
systematic
review
elaborate
on
progress
fundamental
mechanism
NO‐based
in
oncology
this
aspect.
Herein,
key
characteristics
potential
NO
reprogramming
delineated
highlighted.
The
evolution
donors
advantages
discussed
subsequently.
Moreover,
latest
solid
tumors
comprehensively
reviewed,
including
normalizing
overcoming
ECM
barrier,
reversing
MDR,
reactivating
immunosuppression
TME.
Lastly,
prospects,
limitations,
future
directions
manipulation
provide
new
insights
into
construction
more
applicable
anticancer
nanomedicines.
Nanoscale,
Год журнала:
2023,
Номер
15(43), С. 17350 - 17355
Опубликована: Янв. 1, 2023
Perylenediimide-based
J-aggregates
with
significantly
red-shifted
absorption
are
developed
through
the
modulation
of
steric
hindrances
and
used
as
effective
photothermal
agents.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 1, 2023
Gas
therapy
has
gained
noteworthy
attention
in
biomedical
research,
with
the
rise
of
gas-releasing
molecules
enhancing
their
therapeutic
potential,
especially
when
integrated
into
nano-based
drug
delivery
systems.
Herein,
we
present
a
lipid-coated
gas
system
to
simultaneously
shuttle
two
carrying
nitric
oxide
(NO)
and
carbon
monoxide
(CO),
respectively.
Upconversion
nanoparticles
(UCNPs)
are
designed
generate
photons
at
360
nm
upon
808
near-infrared
(NIR)
irradiation.
These
situ-generated
UV
trigger
simultaneous
NO
CO
release
from
S-nitrosoglutathione
(GSNO)
CO-releasing
molecule
(CORM),
respectively,
which
coloaded
UCNP/GSNO/CORM/FA
(LUGCF).
LUGCF
GSNO/CORM
mass
ratio
2:1
is
determined
be
optimal
terms
synergistically
instigating
apoptosis
HCT116
CT26
colon
cancer
cells,
where
both
NO/CO
released
subsequent
production
ROS
detected.
This
CO/NO
combination
nanoplatform
exhibits
very
effective
inhibition
tumor
growth
vivo
relatively
low
doses
mild
Overall,
effectively
one
NIR-responsive
nanosystem,
presenting
promising
strategy
for
future
applications
dual-gas
therapy.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 28, 2024
Gas
therapy
represents
a
promising
strategy
for
cancer
treatment,
with
nitric
oxide
(NO)
showing
particular
potential
in
tumor
therapy.
However,
ensuring
sufficient
production
of
NO
remains
significant
challenge.
Leveraging
ultrasound-responsive
nanoparticles
to
promote
the
release
is
an
emerging
way
solve
this
In
study,
we
successfully
constructed
nanoparticles,
which
consisted
poly
(D,
L-lactide-co-glycolic
acid)
(PLGA)
natural
L-arginine
(LA),
and
superparamagnetic
iron
(SPIO,
Fe3O4
NPs),
denote
as
Fe3O4-LA-PLGA
NPs.
The
NPs
exhibited
effective
therapeutic
effects
both
vitro
vivo,
particularly
NO-assisted
antitumor
gas
photoacoustic
(PA)
imaging
properties.
Upon
exposure
ultrasound
irradiation,
LA
were
rapidly
released
from
PLGA
It
was
demonstrated
that
could
spontaneously
react
hydrogen
peroxide
(H2O2)
present
microenvironment
generate
Concurrently,
H2O2
produce
substantial
quantity
reactive
oxygen
species
(ROS),
can
oxidize
further
facilitate
NO.
conclusion,
proposed
delivery
platform
exhibits
effectively
inhibiting
growth
breast
cancer.
