Nitric Oxide, Год журнала: 2024, Номер 151, С. 17 - 30
Опубликована: Авг. 23, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216540 - 216540
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review discusses the functionalization strategies of ZIF-8 and challenges future developments in ZIF-8-based platforms for drug delivery cancer therapy.
Язык: Английский
Процитировано
0
RSC Advances, Год журнала: 2024, Номер 14(18), С. 12817 - 12828
Опубликована: Янв. 1, 2024
Most MOFs for controllable cancer treatment act as drug delivery vehicle and/or anti-cancer agent. Molecules with roles such chemotherapies, gases, peptides or nucleic acids can be loaded into that decompose in cells the TME to release its cargoes.
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.
Язык: Английский
Процитировано
3
Expert Reviews in Molecular Medicine, Год журнала: 2024, Номер 26
Опубликована: Янв. 1, 2024
Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced new level of rapid development in tumour treatment, their limited therapeutic effectiveness unexpected side effects prevent them from becoming the first option clinical treatment. With advancement nanotechnology, utilization nanomaterials therapeutics offers potential address shortcomings cancer Notably, multifunctional metal-organic framework (MOF) has been widely employed due customizable shape, adjustable diameter, high porosity, diverse compositions, large specific surface area, degree functionalization strong biocompatibility. This paper reviews current progress success MOF-based nanoplatforms for therapy, as well prospects barriers application MOF therapy.
Язык: Английский
Процитировано
3
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 26, 2024
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)
Опубликована: Ноя. 12, 2024
Tumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field nanotechnology has made significant strides enhancing understanding metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation achieve therapeutic goals. This comprehensive review delves into interplay between tumor various facets cancer, encompassing its origins, progression, formidable challenges posed by metastasis. Simultaneously, it underscores classification programmable nanomodulators transformative impact on cancer treatment, particularly when integrated with modalities such as chemotherapy, radiotherapy, immunotherapy. also encapsulates mechanisms which modulate metabolism, including delivery inhibitors, regulation oxidative stress, pH value modulation, nanoenzyme catalysis, nutrient deprivation, RNA interference technology, among others. Additionally, prospects clinical applications. Finally, innovative concept using reprogram pathways introduced, aiming transform cells back normal cells. profound that tailored can have metabolic, charting a path toward pioneering precision therapies
Язык: Английский
Процитировано
2
ACS Omega, Год журнала: 2023, Номер 8(47), С. 44545 - 44557
Опубликована: Ноя. 15, 2023
Extremely short half-life therapeutic molecule nitric oxide (NO) plays significant roles in the functioning of various physiological and pathological processes human body, whereas doxorubicin hydrochloride (DOX) is a clinically important anticancer drug widely used cancer chemotherapy. Thus, intracellular delivery these molecules tremendously to achieve their full potential. Herein, we report novel approach for development highly water-dispersible magnetic nanocarriers codelivery NO DOX. Primarily, bifunctional nanoparticles enriched with carboxyl thiol groups were prepared by introducing cysteine onto surface citrate-functionalized Fe3O4 nanoparticles. DOX was electrostatically conjugated via moieties, group further nitrosated provide NO-releasing molecules. The developed nanocarrier exhibited good aqueous colloidal stability, protein resistance behavior, high encapsulation efficacy (65.5%) (85%), as well sustained release characteristics. Moreover, they showed superior cytotoxicity toward (A549 MCF-7) cells apoptosis induction over normal (WI26VA4) cells. Specifically, have having capability dual DOX, which holds great potential combinatorial treatment.
Язык: Английский
Процитировано
5
Nitric Oxide, Год журнала: 2024, Номер 151, С. 17 - 30
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
1