Biomacromolecules,
Год журнала:
2024,
Номер
25(7), С. 4329 - 4343
Опубликована: Июнь 4, 2024
The
development
of
nanotherapy
targeting
mitochondria
to
alleviate
oxidative
stress
is
a
critical
therapeutic
strategy
for
vascular
calcification
(VC)
in
diabetes.
In
this
study,
we
engineered
mitochondria-targeted
nanodrugs
(T4O@TPP/PEG–PLGA)
utilizing
terpinen-4-ol
(T4O)
as
natural
antioxidant
and
mitochondrial
protector,
PEG–PLGA
the
nanocarrier,
triphenylphosphine
(TPP)
ligand.
vitro
assessments
demonstrated
enhanced
cellular
uptake
T4O@TPP/PEG–PLGA,
with
effective
targeting.
This
nanodrug
successfully
reduced
induced
by
high
glucose
levels
smooth
muscle
cells.
vivo
studies
showed
prolonged
retention
nanomaterials
thoracic
aorta
up
24
h.
Importantly,
experiments
diabetic
VC
models
underscored
potent
properties
evidenced
its
ability
mitigate
restore
morphology.
These
results
suggest
that
these
could
be
promising
managing
VC.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Carbon
dots
(CDs)
are
used
as
photosensitizers
for
the
photodynamic
therapy
of
tumors
while
retaining
specific
functional
groups
and
biochemical
properties
carbon
precursors.
However,
short-wavelength
excitation
limits
their
application
in
tumors.
Upconversion
nanoparticles
(UCNPs)
effectively
solve
problem
low
penetration
due
to
by
converting
low-energy
near-infrared
light
into
high-energy
ultraviolet
or
visible
light.
In
this
paper,
were
prepared
a
hydrothermal
method
using
Salmonella
alendronic
acid
raw
materials,
phosphate
on
surface
coordinated
with
upconversion
form
UCNP@CD
nanoprobes.
Under
irradiation
an
808
nm
laser,
emitted
from
can
further
catalyze
enhance
generation
reactive
oxygen
species
killing
tumor
cells.
Meanwhile,
reprogrammed
M2
macrophages
M1
improve
immunosuppressive
microenvironment.
The
nanoprobes
tumor-associated
macrophage
reprogramming
tumors,
which
provides
effective
strategy
multimodal
synergistic
treatment.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 7037 - 7060
Опубликована: Май 1, 2025
The
diagnosis
and
treatment
of
cancers
have
become
a
significant
challenge
in
overcoming
malignant
diseases.
Early
detection
tumors
timely
targeted
therapy
can
greatly
impede
the
rapid
deterioration
cancers.
In
recent
years,
nano-systems
based
on
photodynamic
materials
shown
great
progress
tumor
applications.
With
continuous
exploration
tumor-specific
targets
development
nanoparticles,
generation
new
nanoparticles
that
are
target-specific,
highly
sensitive,
biosafe
for
integrated
is
realistic.
This
review
introduces
rational
basis
photosensitizer-based
integrating
cancer
anti-cancer
therapy,
types
characteristics
organic
inorganic
photosensitizers
currently
used
PDT
treatment,
photosensitive
nano-materials
with
dual
therapeutic
properties
advancement
developing
photo-dynamic
showing
potential
We
also
introduce
current
strategies
optimizing
enhancing
targeting
ROS
release
accurate
imaging,
combining
efficacy,
as
well
biosafety
integrative
application,
providing
references
coordinated
optimization
photosensitizer
design
clinical
translation.
Uncontrolled
proliferations
and
altered
metabolism
of
cancer
cells
result
an
imbalance
nutrients
as
well
oxygen
supply
persuade
hypoxia.
This
hypoxia
in
turn
activates
the
transcription
gene
HIF-1α
which
eventually
upregulates
efflux
transporter
P-gp
induce
MDR.
Thus,
leads
to
resistance
towards
conventional
therapy
methods.
Therefore,
fabrication
a
nanoscale
porous
system
enriched
with
upconversion
nanoparticle
target
cells,
evade
enhanced
anticancer
is
key
goal
this
chapter.
Herein,
nanoparticles
are
embedded
POP
further
conjugated
targeting
moiety
also
catalase
molecule.
The
UCNPs
generated
room
temperature.
Targeting
ligand
lactobionic
acid
attached
after
polymer
coating
effectively
targets
liver
cells.
Then
grafted
produces
oxygen.
endogenously
alleviates
drug
catalase-loaded
composite
exhibits
more
cytotoxicity
case
hypoxic
than
normal
by
overcoming
downregulating
inducible
factors.
Biomacromolecules,
Год журнала:
2024,
Номер
25(7), С. 4329 - 4343
Опубликована: Июнь 4, 2024
The
development
of
nanotherapy
targeting
mitochondria
to
alleviate
oxidative
stress
is
a
critical
therapeutic
strategy
for
vascular
calcification
(VC)
in
diabetes.
In
this
study,
we
engineered
mitochondria-targeted
nanodrugs
(T4O@TPP/PEG–PLGA)
utilizing
terpinen-4-ol
(T4O)
as
natural
antioxidant
and
mitochondrial
protector,
PEG–PLGA
the
nanocarrier,
triphenylphosphine
(TPP)
ligand.
vitro
assessments
demonstrated
enhanced
cellular
uptake
T4O@TPP/PEG–PLGA,
with
effective
targeting.
This
nanodrug
successfully
reduced
induced
by
high
glucose
levels
smooth
muscle
cells.
vivo
studies
showed
prolonged
retention
nanomaterials
thoracic
aorta
up
24
h.
Importantly,
experiments
diabetic
VC
models
underscored
potent
properties
evidenced
its
ability
mitigate
restore
morphology.
These
results
suggest
that
these
could
be
promising
managing
VC.
