Mitochondria-Targeted Natural Antioxidant Nanosystem for Diabetic Vascular Calcification Therapy

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4329 - 4343

Published: June 4, 2024

The development of nanotherapy targeting mitochondria to alleviate oxidative stress is a critical therapeutic strategy for vascular calcification (VC) in diabetes. In this study, we engineered mitochondria-targeted nanodrugs (T4O@TPP/PEG–PLGA) utilizing terpinen-4-ol (T4O) as natural antioxidant and mitochondrial protector, PEG–PLGA the nanocarrier, triphenylphosphine (TPP) ligand. vitro assessments demonstrated enhanced cellular uptake T4O@TPP/PEG–PLGA, with effective targeting. This nanodrug successfully reduced induced by high glucose levels smooth muscle cells. vivo studies showed prolonged retention nanomaterials thoracic aorta up 24 h. Importantly, experiments diabetic VC models underscored potent properties evidenced its ability mitigate restore morphology. These results suggest that these could be promising managing VC.

Language: Английский

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Self-assembled nanoscale upconversion POP composite for hypoxia relieving and enhanced chemotherapy in hepatocellular carcinoma

Published: Feb. 6, 2024

Uncontrolled proliferations and altered metabolism of cancer cells result an imbalance nutrients as well oxygen supply persuade hypoxia. This hypoxia in turn activates the transcription gene HIF-1α which eventually upregulates efflux transporter P-gp induce MDR. Thus, leads to resistance towards conventional therapy methods. Therefore, fabrication a nanoscale porous system enriched with upconversion nanoparticle target cells, evade enhanced anticancer is key goal this chapter. Herein, nanoparticles are embedded POP further conjugated targeting moiety also catalase molecule. The UCNPs generated room temperature. Targeting ligand lactobionic acid attached after polymer coating effectively targets liver cells. Then grafted produces oxygen. endogenously alleviates drug catalase-loaded composite exhibits more cytotoxicity case hypoxic than normal by overcoming downregulating inducible factors.

Language: Английский

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Introduction to nanophototherapy

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 24

Published: Aug. 30, 2024

Language: Английский

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Recent advances in nanomedicine design strategies for targeting subcellular structures

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111597 - 111597

Published: Dec. 13, 2024

The current state of cancer treatment has encountered limitations, with each method having its own drawbacks. emergence nanotechnology in recent years highlighted potential overcoming these limitations. Nanomedicine offers various drug delivery mechanisms, including passive, active, and endogenous targeting, the advantage modifiability shapability. This flexibility enables researchers to develop tailored treatments for different types tumors populations. As nanodrug technology evolves from first third generation, focus is now on achieving precise by targeting subcellular structures within tumors. review summarizes progress made structure-targeted nanodrugs over past 5 years, highlighting design strategies mitochondria, lysosomes, endoplasmic reticulum, Golgi apparatus, cytoskeleton. also addresses status, future directions about research nanodrugs.

Language: Английский

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Mitochondria-targeting materials and therapies for regenerative engineering

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123023 - 123023

Published: Dec. 15, 2024

Language: Английский

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