The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6099 - 6126

Опубликована: Июнь 1, 2024

Abstract: The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field nanotechnology, with a specific focus on nanocomposites. Nanocomposites, combination nanomaterials diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, therapeutic interventions. Nanocomposites exhibit great potential early detection accurate imaging diagnosis. Integrating various modalities, such magnetic resonance (MRI), computed tomography (CT), fluorescence into nanocomposites enables development contrast agents enhanced sensitivity specificity. Moreover, functionalizing targeting ligands ensures selective accumulation tumor tissues, facilitating precise diagnostic accuracy. On front, revolutionized by overcoming traditional challenges associated drug delivery. controlled release from nanocomposite carriers enhances bioavailability, reduces systemic toxicity, improves overall efficacy. Additionally, integration stimuli-responsive components within site-specific triggered unique microenvironment tumor. Despite remarkable progress field, biocompatibility, scalability, long-term safety profiles remain. This article provides comprehensive overview recent developments, challenges, prospects, emphasizing transformative revolutionizing landscape diagnostics therapeutics. In Conclusion, integrating heralds new era precision medicine. Keywords: nanocomposites, cancer, diagnosis, therapy, nanoparticles, theranostic

Язык: Английский

---

Fucoidan and its derivatives: From extraction to cutting-edge biomedical applications

Carbohydrate Polymers, Год журнала: 2025, Номер 357, С. 123468 - 123468

Опубликована: Март 1, 2025

Язык: Английский

---

Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Small, Год журнала: 2024, Номер 20(26)

Опубликована: Фев. 22, 2024

Abstract Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture stratum corneum layer of skin lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, drug administration. offer limited invasiveness, ease application, minimal discomfort. Initially manufactured solely from metals, now available polymer‐based varieties. can be used create systems that deliver drugs chemicals uniformly, collect fluids, stimulus‐sensitive. Although these advancements favorable terms biocompatibility production costs, they insufficient for use MNs. This is first comprehensive review discusses individual MN toward evolution development smart multifunctional a variety novel impactful future applications. The study examines fabrication techniques, application purposes, experimental details constructs perform multiple concurrently, sensing, drug‐molecule release, sampling, remote communication capabilities. It highly likely near future, MN‐based will useful important component standard practice different

Язык: Английский

---

Dual Metal Nanoflower Oxygen Pump Microneedles Based on Cuproptosis and STING Pathway Activation for Cancer Immunotherapy

Small, Год журнала: 2025, Номер 21(11)

Опубликована: Фев. 14, 2025

Abstract Immunotherapy is a promising new approach for tumor treatment. However, its clinical application hindered by insufficient immunogenicity, hypoxia, and immunosuppressive microenvironment (TME). Here, oxygen pump microneedles (OPMNs) loaded with zinc‐doped copper sulfide nanoflowers (ZCS NFs) PD‐L1 small interfering RNA (siPD‐L1) (OPMNs‐ZCS@siPD‐L1) are developed boosting immunotherapy. OPMN‐ZCS@siPD‐L1 enhances immunogenicity through ZCS NFs inducing cuproptosis, reverses TME siPD‐L1, promotes drug penetration, ameliorates hypoxia bubbles. More importantly, cuproptosis‐induced mitochondrial DNA (mtDNA) together Zn 2+ co‐activate the STING pathway, triggering robust immune response. increases sensitivity to cuproptosis induces immunogenic cell death (ICD) in vivo vitro, which significantly inhibits progression metastasis. The novel strategy of “increasing throttle” (cuproptopsis‐mediated activation & ICD effect) combined “releasing brake” (PD‐L1 inhibition improvement) provides enhancing percutaneous

Язык: Английский

---

Chemodynamic therapy combined with endogenous ferroptosis based on “sea urchin-like” copper sulfide hydrogel for enhancing anti-tumor efficacy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 660, С. 124330 - 124330

Опубликована: Июнь 12, 2024

Язык: Английский

---

Partitioned Microneedle Patch Based on NO Release and HSP Inhibition for mPTT/GT Combination Treatment of Melanoma

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(37), С. 49104 - 49113

Опубликована: Сен. 5, 2024

Photothermal therapy (PTT) shows promise in cancer treatments due to its good spatiotemporal selectivity and minimal invasiveness. However, PTT has some problems such as excessive heat damage normal tissues, tumor thermo-resistance caused by shock proteins (HSPs), limited efficacy of monotherapy. Here, we construct a patch named "partitioned microneedles" (PMN-SNAP/CuS), which separates the "catalyst" bovine serum albumin-based copper sulfide nanoparticles (CuS@BSA NPs) "reactant"

Язык: Английский

---

Nuclear-targeted smart nanoplatforms featuring double-shell hollow mesoporous copper sulfide coated with manganese dioxide synergistically potentiate chemotherapy and immunotherapy in hepatocellular carcinoma cells

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 680, С. 202 - 214

Опубликована: Ноя. 2, 2024

Язык: Английский

---

Advance of the application of seaweed polysaccharides on antitumor drug delivery systems

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125502 - 125502

Опубликована: Март 1, 2025

Язык: Английский

---

The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 286 - 286

Опубликована: Фев. 17, 2024

Transdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter challenge a low transdermal absorption rate. Microneedles can overcome stratum corneum barrier to enhance Among various types microneedles, nanoparticle-loaded dissolving microneedles (DMNs) present unique combination advantages, leveraging strengths DMNs (high payload, good mechanical properties, easy fabrication) nanocarriers (satisfactory solubilization capacity controlled release profile). Consequently, hold considerable clinical potential precision medicine era. Despite this promise, no DMN products been approved thus far. The lack understanding regarding their vivo fate represents critical bottleneck impeding translation relevant products. This review aims elucidate current research status elaborate necessity investigate from diverse aspects. Furthermore, it offers insights into entry points for DMNs, aiming foster further advancements field.

Язык: Английский

---

pH-responsive oxygen self-sufficient smart nanoplatform for enhanced tumor chemotherapy and photodynamic therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 675, С. 1080 - 1090

Опубликована: Июль 14, 2024

Язык: Английский

---