Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
Severe
skin
wounds
arising
from
burns,
cancers,
and
accidents
can
damage
the
entire
tissue
structure,
resulting
in
permanent
somatosensory
dysfunction
patients.
Although
emerging
hydrogel
dressings
have
shown
clinical
potential
for
accelerating
wound
repair,
use
of
an
individual
material
to
synchronously
restore
structure
sensory
function
defective
remains
a
challenge.
Herein,
multifunctional
that
combines
electroconductive
polydopamine‐capped
graphene
nanosheets
(PrGOs)
embedded
dynamically
crosslinked
dual‐polysaccharide
(xyloglucan
chitosan)
matrix
network
is
presented.
The
fabricated
hydrogels
adjustable
modulus
be
matched
at
site,
owing
dynamic
Schiff‐based
crosslinking
as
well
facile
photo‐triggered
secondary
crosslinking.
Furthermore,
photothermal
activity
PrGO
elevate
local
temperature
up
≈50
°C,
significantly
restraining
bacterial
growth.
These
two
factors
jointly
promote
regeneration
tissue.
Tissue
adhesion
also
reported
offers
conformable
robust
interface
detect
quantify
human
movement
physiological
signals
mimic
system.
This
effective
one‐stone‐for‐two‐birds
simultaneously
achieves
multi‐signal
sensing,
promoting
restoration
and/or
replacement
damaged
skins.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 131277 - 131277
Опубликована: Март 31, 2024
Bacteria-infected
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
Wound
dressing
is
a
potential
strategy
for
repairing
infectious
wounds.
However,
the
development
of
with
appropriate
physiochemical,
antibacterial,
and
hemostatic
properties,
remains
challenging.
Hence,
there
motivation
to
develop
new
synthetic
dressings
improve
bacteria-infected
healing.
Here,
we
fabricate
biocompatible
sponge
through
covalent
crosslinking
collagen
(Col),
quaternized
chitosan
(QCS),
graphene
oxide
(GO).
The
resulting
Col-QCS-GO
shows
an
elastic
modulus
1.93-fold
higher
than
Col
due
enhanced
degree
by
GO
incorporation.
Moreover,
fabricated
favorable
porosity
(84.30
±
3.12
%),
water
absorption/retention
(2658.0
113.4
%/1114.0
65.7
hemostasis
capacities
(blood
loss
<50.0
mg).
Furthermore,
antibacterial
property
under
near-infrared
(NIR)
irradiation
significantly
(the
inhibition
rates
are
99.9
%
S.
aureus
E.
coli)
inherent
properties
QCS
photothermal
capabilities
GO.
Finally,
Col-QCS-GO+NIR
exhibits
lowest
percentage
area
(9.05
1.42
%)
at
day
14
compared
control
group
(31.61
1.76
%).
This
study
provides
insights
developing
innovative
sponges
Advanced Materials Technologies,
Год журнала:
2024,
Номер
9(15)
Опубликована: Май 7, 2024
Abstract
Controllable
and
long‐term
release
remains
a
great
challenge
in
current
drug
delivery
systems.
Benefiting
from
their
efficient
loading
painless
administration,
microneedles
(MNs)
have
emerged
as
promising
platform
for
transdermal
delivery,
while
they
often
fail
to
achieve
tissue
adhesion
controllable
extended
release.
Here,
3D
printing
of
an
innovative
MN
patch
is
presented
with
succulent‐inspired
responsive
microstructures
light‐controllable
capability.
The
exhibits
reversible
shrink‐swell
volume
change
behavior
response
surrounding
humidity,
which
enables
sufficient
mechanical
strength
skin
penetration
under
the
shrinkage
conditions
when
swollen
tissues.
Moreover,
introduces
system,
achieved
through
integration
thiolated
heparin
(Hep‐SH)
sustained
growth
factor
graphene
oxide
(GO)
nanosheets
controlled
via
near
infrared
(NIR)
laser
irradiation.
patches
good
biocompatibility
can
promote
proliferation,
migration,
proangiogenesis
endothelial
cells
further
demonstrated.
Thus,
it
believed
that
such
flexible
be
candidates
well
other
related
engineering
applications.
Gels,
Год журнала:
2024,
Номер
10(8), С. 495 - 495
Опубликована: Июль 26, 2024
Bacterial
infection
treatment
for
chronic
wounds
has
posed
a
major
medical
threat
and
challenge.
Bacteria
at
the
wounded
sites
can
compete
with
immune
system
subsequently
invade
live
tissues,
leading
to
more
severe
tissue
damage.
Therefore,
there
is
an
urgent
demand
wound
dressings
antibacterial
anti-inflammatory
properties.
Considering
concept
of
moist
healing,
hydrogels
three-dimensional
(3D)
network
structure
are
widely
used
as
due
their
excellent
hydrophilicity,
water
retention
properties,
biocompatibility.
Developing
infected
been
receiving
extensive
attention
recently.
This
article
categorizes
according
materials
modes,
introduces
recent
findings
progress
regarding
status.
More
importantly,
development
emerging
technologies,
new
therapies
utilized
prepare
such
nanoenzymes,
photothermal
therapy
(PTT),
photodynamic
(PDT),
metal–organic
frameworks
(MOFs),
other
external
stimuli-responsive
methods.
this
review
also
examines
progress,
challenges,
future
trends
dressings.
In
following
studies,
will
still
be
focus
on
that
have
high
performance,
multi-functions,
intelligence,
especially
biocompatibility,
long-lasting
property,
responsiveness,
on-demand
therapeutic
ability.
Chemistry of Materials,
Год журнала:
2024,
Номер
36(12), С. 6114 - 6129
Опубликована: Июнь 3, 2024
Wound
healing
is
a
prolonged
physiological
process
involving
series
of
complicated
biological
responses
influenced
by
various
factors,
such
as
bacterial
infection
and
oxidative
damage.
Existing
treatments,
while
effective,
have
certain
limitations
in
terms
biocompatibility,
responsiveness
to
the
wound
environment,
efficacy
promoting
tissue
regeneration.
To
address
these
shortcomings,
bioinspired
hydration
lubrication
mechanism
articular
cartilage,
we
successfully
designed
developed
an
injectable
situ
photo-cross-linkable
hydrogel,
which
was
synthesized
via
modifying
aminated
hyaluronic
acid
with
polymer
obtained
free
radical
polymerization
o-nitrobenzyl
alcohol
derivative
(NB)
2-methoxyethyl
phosphocholine
(MPC).
The
hydrophilic
layer
formed
around
zwitterionic
charges
MPC
endowed
hydrogel
enhanced
antimicrobial
effects,
whereas
hydroxymethyl
group
NB
enabled
ultraviolet
light-induced
cross-linking
property.
doped
polydopamine
nanoparticles,
facilitated
multifaceted
photothermally
responsive
antibacterial,
anti-inflammation,
angiogenesis.
Specifically,
upon
injection
precursor
solution
into
site
exposure
light,
cross-linked
adhered
closely
skin
tissues,
achieving
hemostasis
exudate
absorption.
Additionally,
showed
excellent
reactive
oxygen
species
scavenging
property,
reducing
cellular
stress
meanwhile
bactericidal
effect
near-infrared
light
irradiation.
Furthermore,
its
networked
porous
structure,
conducive
cell
adhesion
proliferation,
remarkably
enhancing
activity
wound-healing
performances
were
investigated
both
vitro
vivo
experiments,
showcasing
potential
for
treatment
applications,
offering
promising
improvement
over
current
methods
providing
photothermal
responsive,
biocompatible,
effective
process.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(11), С. 13590 - 13602
Опубликована: Июнь 6, 2024
Polydopamine
(PDA)
exhibits
admirable
photothermal
properties
and
biocompatibility
for
biomedical
applications;
however,
its
near-infrared
(NIR-II)
absorption
antibacterial
performance
remain
insufficient.
Herein,
we
introduced
Fe-doped
molybdenum
oxide
(MoFeOx)
functionalized
PDA
composites
exhibiting
robust
NIR
absorption,
reactive
oxygen
species
(ROS)
generation,
glutathione
(GSH)
depletion,
thereby
achieving
a
synergistic
therapy/chemodynamic
effect.
Polyethylenimine
(PEI)
served
as
the
interlayer
to
bind
MoFeOx
onto
surface
of
through
electrostatic
interaction.
Compared
with
pure
PDA,
nanoparticles
demonstrated
145%
improvement
in
efficiency
NIR-II
range
(1064
nm)
when
incorporating
only
2.2%
MoFeOx.
This
was
attributed
generation
electron
"donor"
"acceptor"
within
material,
resulting
reduction
energy
band
gap
enhanced
migration,
characterized
by
ultraviolet
photoelectron
spectroscopy
(UPS).
The
exhibited
therapeutic
effects
on
E.
coli
S.
aureus
photothermal/chemodynamic
therapy.
work
offers
an
alternative
methodology
improving
designing
materials.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(28), С. 6968 - 6980
Опубликована: Янв. 1, 2024
Postoperative
adhesions,
a
prevalent
complication
following
abdominal
surgery,
affect
90%
of
patients
undergoing
surgical
procedures.
Currently,
the
primary
approach
to
prevent
postoperative
adhesions
involves
physical
isolation
site
and
surrounding
tissues
using
hydrogel;
however,
this
method
represents
rudimentary
strategy.
Herein,
considering
impact
oxidative
stress
free
radicals
on
adhesion
during
wound
healing,
an
injectable
antioxidant
hydrogel,
named
PU-OHA-D,
was
successfully
synthesized,
which
is
formed
by
crosslinking
dopamine-modified
oxidized
hyaluronic
acid
(OHA-D)
dihydrazide-terminated
polyurethane
(PU-ADH)
through
hydrazone
bonding.
PU-OHA-D
hydrogel
possesses
versatile
characteristics
such
as
rapid
gel
formation,
injectability,
self-repair
capability
biodegradability.
Additionally,
they
exhibit
excellent
ability
clear
superior
tissue
adhesion.
can
be
injected
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
