Cupric-polymeric Nanoreactors Integrate into Copper Metabolism to Promote Chronic Diabetic Wounds Healing
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101087 - 101087
Опубликована: Май 11, 2024
Given
multifunction
of
copper
(Cu)
contributing
to
all
stages
the
physiology
wound
healing,
Cu-based
compounds
have
great
therapeutic
potentials
accelerate
but
they
must
be
limited
a
very
low
concentration
range
avoid
detrimental
accumulation.
Additionally,
cellular
mechanism
participating
healing
process
remains
elusive.
In
this
study,
oxide
nanoparticles
(CuONPs)
were
synthesized
mimic
multiple
natural
enzymes
and
trapped
into
PEG-
Язык: Английский
Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(32)
Опубликована: Окт. 14, 2024
Abstract
Chronic
wounds
are
characterized
by
long‐term
inflammation,
including
diabetic
ulcers,
traumatic
etc.,
which
provide
an
optimal
environment
for
bacterial
proliferation.
At
present,
antibiotics
the
main
clinical
treatment
method
chronic
wound
infections.
However,
overuse
of
may
accelerate
emergence
drug‐resistant
bacteria,
poses
a
significant
threat
to
human
health.
Therefore,
there
is
urgent
need
develop
new
therapeutic
strategies
Nanozyme‐based
antimicrobial
therapy
(NABT)
emerging
strategy
with
broad‐spectrum
activity
and
low
drug
resistance
compared
traditional
antibiotics.
NABT
has
shown
great
potential
as
catalyzing
generation
reactive
oxygen
species
(ROS)
its
enzyme‐like
catalytic
properties,
producing
powerful
bactericidal
effect
without
developing
resistance.
cascade
technology
offers
approach
infection
control,
effectively
improving
efficacy
activating
cascades
against
cell
membranes
intracellular
DNA
while
minimizing
side
effects.
it
worth
noting
that
this
still
in
early
stages
research.
This
article
comprehensively
reviews
classification,
current
methods
infection,
different
types
nanozymes,
application
nanozyme
reaction
therapy,
future
challenges
prospects.
Язык: Английский
Nanofibrous membrane/self-healing hydrogel double-layer nanocomposite dressings based on oxidized dextran and carboxymethyl chitosan loading ZIF-nanozyme for enhanced bacterial-infected diabetic wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
313, С. 144292 - 144292
Опубликована: Май 16, 2025
Язык: Английский
How Nanoparticles Help in Combating Chronic Wound Biofilms Infection?
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 11883 - 11921
Опубликована: Ноя. 1, 2024
Chronic
wound
infection
has
become
a
global
health
problem,
with
bacterial
biofilms,
which
are
difficult
to
penetrate
using
traditional
antibiotics,
considered
the
primary
cause
of
recurrent
and
delayed
healing
in
chronic
wounds.
In
recent
years,
outstanding
performance
nanomaterials
controlling
biofilm
infections
been
widely
acknowledged,
these
materials
regarded
as
highly
promising
for
management.
The
formation
structure
biofilms
undergo
complex
dynamic
changes.
Therefore,
deep
understanding
underlying
causes
repeated
specific
antibacterial
mechanisms
at
different
stages
is
crucial
effective
"chronic
management".
This
review
first
reveals
relationship
between
chronicity,
infections.
Secondly,
it
focuses
on
four
formation:
(1)
adhesion
stage,
(2)
aggregation
promotion
(3)
maturation
(4)
regeneration
dissemination
stage.
It
also
comprehensively
summarizes
nanomaterials.
study
analyzes
essential
factors
affecting
control
by
nanoparticles
from
various
perspectives,
such
material
itself,
local
environment,
systemic
host
response.
Finally,
limitations
potential
future
trends
current
research
discussed.
summary,
represent
strategy
combating
infections,
this
provides
new
insights
alternative
adjuvant
therapies
managing
Язык: Английский
Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers
Xueqian Xiao,
Fei Zhao,
Davida Briana DuBois
и другие.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4195 - 4226
Опубликована: Май 16, 2024
Diabetic
foot
ulcers
(DFU)
are
chronic,
refractory
wounds
caused
by
diabetic
neuropathy,
vascular
disease,
and
bacterial
infection,
have
become
one
of
the
most
serious
persistent
complications
diabetes
mellitus
because
their
high
incidence
difficulty
in
healing.
Its
malignancy
results
from
a
complex
microenvironment
that
includes
series
unfriendly
physiological
states
secondary
to
hyperglycemia,
such
as
recurrent
infections,
excessive
oxidative
stress,
inflammation,
ischemia
hypoxia.
However,
current
common
clinical
treatments,
antibiotic
therapy,
insulin
surgical
debridement,
conventional
wound
dressings
all
drawbacks,
suboptimal
outcomes
exacerbate
financial
physical
burdens
patients.
Therefore,
development
new,
effective
affordable
treatments
for
DFU
represents
top
priority
improve
quality
life
In
recent
years,
nanozymes-based
therapy
systems
been
attracting
extensive
interest
integrating
unique
advantages
nanomaterials
natural
enzymes.
Compared
with
enzymes,
nanozymes
possess
more
stable
catalytic
activity,
lower
production
cost
greater
maneuverability.
Remarkably,
many
multienzyme
activities
can
cascade
multiple
enzyme-catalyzed
reactions
simultaneously
throughout
recovery
process
DFU.
Additionally,
favorable
photothermal-acoustic
properties
be
exploited
further
enhancement
therapeutic
effects.
this
review
we
first
describe
characteristic
pathological
DFU,
then
discuss
mechanisms
applications
healing,
finally,
highlight
challenges
perspectives
nanozyme
treatment.
Язык: Английский
Vesicle-like Nanocapsules Formed by Self-Assembly of Peptides with Oligoproline and -Leucine
Langmuir,
Год журнала:
2024,
Номер
40(24), С. 12802 - 12809
Опубликована: Июнь 8, 2024
Since
drug
carriers
are
envisaged
to
be
used
in
a
wide
variety
of
situations
and
environments,
nanocarriers
with
diverse
properties,
such
as
biocompatibility,
biodegradability,
nonimmunogenicity,
adequate
particle
size,
robustness,
cell
permeability,
required.
Here,
we
report
the
construction
novel
nanocapsules
above-mentioned
features
by
self-assembly
peptides
composed
oligoproline
oligoleucine
(i.e.,
H-Pro10Leu4-NH2
H-Pro10Leu6-NH2).
The
self-organized
via
hydrogen
bonds
hydrophobic
interactions
between
moieties
form
vesicle-like
cationic
exposed
on
surface.
guest
encapsulation
experiments
revealed
that
were
capable
uptake
both
water-soluble
insoluble
compounds.
Furthermore,
positively
charged
and/or
oligoproline-based
known
improve
permeability
cellular
uptake,
suggesting
peptide
good
candidates
for
complement
liposomes
polymer
micelles.
Язык: Английский